104632-27-1

• 常用中文名：普拉克索杂质D
• 常用英文名：Dexpramipexole (dihydrochloride)
• CAS号：104632-27-1
• 分子式：C₁₀H₁₉Cl₂N₃S
• 分子量：284.24900
• 相关类别： 分析化学 标准品 药典标准品和杂志标准品
• 发布时间：2018-05-16 08:00:00
• 更新时间：2026-07-01 22:14:17
• Dexpramipexole(KNS-760704)双盐酸盐也叫R-(+)-Pramipexole，是神经保护剂，是弱的非麦角类多巴胺受体激动剂。

名称

• 中文名: R-普拉克索盐酸盐
• 英文名: (6R)-6-N-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine,dihydrochloride
• 中文别名: (R)-N6-丙基-4,5,6,7-四氢苯并噻唑-2,6-二胺二盐酸盐; 盐酸普拉克索杂质4 双盐酸盐; 普拉克索杂质D DIHCI; 普拉克索R-异构体; 普拉克索杂质D DIHCL; 盐酸普拉克索杂质; 盐酸普拉克索杂质4 双盐酸盐(盐酸普拉克索杂质D 双盐酸盐); 右旋普拉克索二盐酸盐; 普拉克索杂质D二盐酸盐; 盐酸普拉克索杂质D; 普拉克索杂质D双盐酸盐; 右旋普拉克索二盐酸盐,10 MM DMSO 溶液; 盐酸普拉克索杂质IV; 盐酸普拉克索杂质(5个); 普拉克索杂质D 标准品; 普拉克索杂质D HCL
• 英文别名: (+)-Pramipexole dihydrochloride; SND 919CL2x; Pramipexole BP Impurity D; Pramipexole impurity D CRS; Pramipexole Impurity 4 Dihydrochloride; Bio-0080; Glycerol Impurity 41((R)-3-chloropropane-1,2-diol); (R)-Pramipexole (hydrochloride); CS-1195; Kns; (-)-2-amino-6-propylamino-4,5,6,7-tetrahydrobenzothiazole dihydrochloride; Dopamine Rector,inhibit,Inhibitor,KNS-760704,Dexpramipexole,Dexpramipexole dihydrochloride,(R)-Pramipexole,KNS760704,KNS; Dexpramipexole HCl; Pramipexole R-Isomer; (+)-2-amino-6-(propylamino)tetrahydrobenzothiazole dihydrochloride; DexpraMipexole (dihydrochloride); Dexpramipexole dihydrochloride ((R)-Pramipexole; 2,6-Benzothiazolediamine,4,5,6,7-tetrahydro-N6-propyl-,dihydrochloride,(R); (R)-2-Amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole dihydrochloride // (R)-Pramipexole dihydrochloride; Pramipexole dihydrochloride impurity IV; Pramipexole Related Compound D ((R)-2-Amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole dihydro; Pramipexole Dihydrochloride Hydrate IMP; (R)-4,5,6,7-Tetrahydro-6-(propylamino)-benzothiazole-2-amine dihydrochloride; KNS-760704 dihydrochloride; UNII-I9038PKO43; PraMipexole IMpurity D; Pramipexole Impurity D (R-Isomer); Pramipexole Impurity D HCl; Pramipexole Impurity D ((R)-Pramipexole diHCl); Dexpramipexole 2HCl; (R)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine dihydrochloride; Snd 919cl2x; Pramipexole Impurity D DiHCl; 2,6-Benzothiazolediamine, 4,5,6,7-tetrahydro-N6-propyl-, dihydrochloride, (R); Dexpramipexole dihydrochloride, 10 mM in DMSO; (R)-PRAMIPEXOLE DIHYDROCHLORIDE; KNS 760704; SND 919CL2X; Pramipexole Dihydrochloride Hydrate Impurity; (+)-2-amino-4,5,6,7-tetrahydro-6-L-propylaminobenzathiazole dihydrochloride; Pramipexole Impurity 4 Dihydrochloride（Pramipexole Impurity D Dihydrochloride）; Dexpramipexole dihydrochloride ((R)-Pramipexole dihydrochloride

物化性质

• 分子式: C₁₀H₁₉Cl₂N₃S
• 分子量: 284.24900
• 精确质量: 283.06800
• PSA: 79.91000
• LogP: 3.50720
• 外观性状: white to beige
• 储存条件: ?20°C
• 水溶解性: H2O: >15mg/mL

生物活性

• 描述: Dexpramipexole(KNS-760704)双盐酸盐也叫R-(+)-Pramipexole,是神经保护剂,是弱的非麦角类多巴胺受体激动剂。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 多巴胺受体
  信号通路 >> 神经信号通路 >> 多巴胺受体
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Rudnicki SA, Berry JD, Ingersoll E, et al. Dexpramipexole effects on functional decline and survival in subjects with amyotrophic lateral sclerosis in a Phase II study: subgroup analysis of demographic and clinical characteristics. Amyotroph Lateral Scler

  [2]. Alavian KN, Dworetzky SI, Bonanni L, et al. Effects of dexpramipexole on brain mitochondrial conductances and cellular bioenergetic efficiency. Brain Res. 2012 Mar 29;1446:1-11.

  [3]. Cudkowicz M, Bozik ME, Ingersoll EW, et al. The effects of dexpramipexole (KNS-760704) in individuals with amyotrophic lateral sclerosis. Nat Med. 2011 Nov 20;17(12):1652-6.

  [4]. Bozik ME, Mather JL, Kramer WG, et al. Safety, tolerability, and pharmacokinetics of KNS-760704 (dexpramipexole) in healthy adult subjects. J Clin Pharmacol. 2011 Aug;51(8):1177-85.

  [5]. Cheah BC, Kiernan MC. Dexpramipexole, the R(+) enantiomer of pramipexole, for the potential treatment of amyotrophic lateral sclerosis. IDrugs. 2010 Dec;13(12):911-20.

安全

• 符号: GHS07
• 信号词: Warning
• 危害声明: H315-H319-H335
• 警示性声明: P261-P305 + P351 + P338
• 危害码 (欧洲): Xi
• 风险声明 (欧洲): 36/37/38
• 安全声明 (欧洲): 26
• 危险品运输编码: NONH for all modes of transport