173334-58-2

173334-58-2结构式

常用中文名：阿利克仑半富马酸盐
常用英文名：Aliskiren hemifumarate
CAS号：173334-58-2
分子式：C₆₄H₁₁₀N₆O₁₆
分子量：1219.59000
相关类别：生物化工抑制剂内分泌及激素(Endocrinology & Hormones) RAAS 抑制剂
发布时间：2018-03-01 08:00:00
更新时间：2026-07-01 00:30:26
Aliskiren(CGP 60536)半富马酸盐是肾素的直接抑制剂,IC50为1.5 nM。

化源商城直购

中文名	阿利吉仑半富马酸盐
英文名	Aliskiren hemifumarate
中文别名	肾素抑制剂(ALISKIREN HEMIFUMATE) 半富马酸阿利克仑半延胡索酸阿利吉仑阿利克伦半富马酸阿利吉仑杂质化合物：Aliskiren Hemifumate 化合物:Aliskiren Hemifumate 阿利克仑半富马酸盐/Aliskiren Hemifumate 阿利吉仑ALISKIRENHEMIFUMATE 阿利克仑半富马酸盐,10 MM DMSO 溶液阿利克伦扮富马酸盐富马酸阿利吉仑 (2S,4S,5S,7S)-5-氨基-N-(2-氨基甲酰基-2-甲基丙基)-4-羟基-2-异丙基-7-[4-甲氧基-3-(3-甲氧基丙氧基)苄基]-8-甲基壬酰胺半富马酸盐阿里克伦半富马酸盐阿立克仑半富马酸盐阿立克他半富马西双盐阿利G仑半富马酸盐 (2S,4S,5S,7S)-5-氨基-N-(3-氨基-2,2-二甲基-3-氧代丙基)-4-羟基-2-异丙基-7-(4-甲氧基-3-( 3-甲氧基丙氧基)苄基)-8-甲基壬酰胺半富马酸盐
英文别名	Aliskiren fumarate Rasilez HeMifuMate ALISKIREN FUMATE Benzeneoctanamide, δ-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-γ-hydroxy-4-methoxy-3-(3-methoxypropoxy)-α,ζ-bis(1-methylethyl)-, (αS,γS,δS,ζS)-, (2E)-2-butenedioate (2:1) Aliskiren hemifumate //BP Aliskiren (2S,4S,5S,7S)-5-Amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-8-methylnonanamide (2E)-2-butenedioate (2:1) (2S,4S,5S,7S)-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-5-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-8-methylnonanamide hemifumate (αS,γS,δS,ζS)-δ-Amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-γ-hydroxy-4-methoxy-3-(3-methoxypropoxy)-α,ζ-bis(1-methylethyl)benzeneoctanamide hemifumate SPP 100 hemifumate Benzeneoctanamide, δ-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-γ-hydroxy-4-methoxy-3-(3-methoxypropoxy)-α,ζ-bis(1-methylethyl)-, (αS,γS,δS,ζS)-, (2E)-2-butenedioate (2:1) (salt) (alphaS,gammaS,deltaS,Zetas)-delta-amino-N-(3-amino-2,2-dimethyl-3-oxo-propyl)-gamma-hydroxy-4-methoxy-3-(3-methoxy-propoxy)-alpha,zeta-bisisopropylbenzeneoctanamide fumate (2:1) CCRIS CGP 60536 Aliskirenhemifumarate Alicran-d6 (semi-fumate) acide (2E)-but-2-ènedioïque - (2S,4S,5S,7S)-5-amino-N-(3-amino-2,2-diméthyl-3-oxopropyl)-4-hydroxy-7-[4-méthoxy-3-(3-méthoxypropoxy)benzyl]-8-méthyl-2-(1-méthyléthyl)nonanamide (1:2) Rasilez (αS,γS,δS,zS)-δ-Amino-N-(3-amino-2,2-diMethyl-3-oxopropyl)-γ-hydroxy-4-Methoxy-3-(3-Methoxypropoxy)-α,z-bis(1-Methylethyl)benzeneoctanaMide HeMifuMate Aliskiren hemifumate (2S,4S,5S,7S)-5-Amino-N-(2-cbamoyl-2-methylpropyl)-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-8-methylnonanamide hemifumate Aliskiren Hemifumate Benzeneoctanamide, delta-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-gamma-hydroxy-4-methoxy-3-(3-methoxypropoxy)-alpha,zeta-bis(1-methylethyl)-, (alphas,gammas,deltas,zetas)-, (2E)-2-butenedioate (2:1) (salt) Aliskiren hemifumate - Bio-X benzeneoctanamide, δ-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-γ-hydroxy-4-methoxy-3-(3-methoxypropoxy)-α,ζ-bis(1-methylethyl)-, (αS,γS,δS,ζS)-, (2E)-2-butenedioate (2:1 CGP60536B Unii-C8A0p8G029 CGP 60536 hemifumate Tekturna HeMifuMate skiren heMifuMate (2S,4S,5S,7S)-5-Amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methylnonanamide hemifumate CGP60536B hemifumate tekturna (2S,4S,5S,7S)-5-Amino-N-(2-cbamoyl-2-methylpropyl)-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-8-methylnonanamide hemifumate Aliskiren hemifumerate Aliskiren hemifumate, 10 mM in DMSO (2E)-But-2-endisäure--(2S,4S,5S,7S)-5-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-8-methyl-2-(1-methylethyl)nonanamid(1:2) (2S,4S,5S,7S)-5-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-8-methyl-2-(1-methylethyl)nonanamide (2E)-but-2-enedioate (2:1) (salt) Benzeneoctanamide, δ-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-γ-hydroxy-4-methoxy-3-(3-methoxypropoxy)-α,ζ-bis(1-methylethyl)-, (αS,γS,δS,ζS)-, (2E)-2-butenedioate (2:1 ) (salt) Aliskiren (hemifumarate) SPP 100 Aliskiren hemifumate CAS NO.173-2 (2S,4S,5S,7S)-5-Amino-N-(2-carbamoyl-2,2-dimethylethyl)-4-hydroxy-7-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-8-methyl-2-(propan-2-yl)nonanamide hemifumarate

描述	Aliskiren(CGP 60536)半富马酸盐是肾素的直接抑制剂,IC50为1.5 nM。
相关类别	信号通路 >> 自噬 >> 自噬信号通路 >> 代谢酶/蛋白酶 >> 肾素研究领域 >> 心血管疾病
参考文献	[1]. Yuji Nakamura, et al. Discovery of DS-8108b, a Novel Orally Bioavailable Renin Inhibitor. ACS Med. Chem. Lett., 2012, 3 (9), pp 754–758 [2]. Buczko W, et al. Pharmacokinetics and pharmacodynamics of aliskiren, an oral direct renin inhibitor. Pharmacol Rep. 2008 Sep-Oct;60(5):623-31. [3]. Wood JM, et al. Structure-based design of aliskiren, a novel orally effective renin inhibitor.Biochem Biophys Res Commun, 2003, 308(4), 698-705. [4]. Gradman AH, et al.Aliskiren, a novel orally effective renin inhibitor, provides dose-dependent antihypertensive efficacy and placebo-like tolerability in hypertensive patients. Circulation, 2005, 111(8), 1012-1018.

熔点	72-75?C
分子式	C₆₄H₁₁₀N₆O₁₆
分子量	1219.59000
精确质量	1218.80000
PSA	366.86000
LogP	9.88180
蒸汽压	1.59E-23mmHg at 25°C
储存条件	Hygroscopic, -20°C Freezer, Under Inert Atmosphere

危害码 (欧洲)	Xi

1236549-06-6

110-17-8

~97%

173334-58-2

文献：CHEMO IBERICA, S. A.; CARCONE, Luca; MAGRONE, Domenico; BARRECA, Giuseppe; RASPARINI, Marcello; LI MING, Huan Patent: WO2013/14191 A1, 2013 ; Location in patent: Page/Page column 19; 20 ;

173338-07-3

110-17-8

~86%

173334-58-2

文献：CHEMO IBERICA, S. A.; CARCONE, Luca; MAGRONE, Domenico; BARRECA, Giuseppe; RASPARINI, Marcello; LI MING, Huan Patent: WO2013/14191 A1, 2013 ; Location in patent: Page/Page column 19 ;

110-17-8

173334-57-1

~81%

173334-58-2

文献：JUBILANT LIFE SCIENCES LIMITED; BISWAS, Sujay; SRIMURUGAN, Sankareswaran; KUMAR, Anjul; PANDA, Atulya, Kumar; JAMSHAD, Danish; MASAND, Mukesh; BISWAS, Bidyut; BANSAL, Vikas; GUPTA, Ashish, Kumar; VIR, Dharam Patent: WO2013/61224 A1, 2013 ; Location in patent: Page/Page column 25 ;