126544-47-6

• 常用中文名：环索奈德
• 常用英文名：Ciclesonide
• CAS号：126544-47-6
• 分子式：C₃₂H₄₄O₇
• 分子量：540.68800
• 相关类别： 分析化学 标准品 药典标准品和杂志标准品
• 发布时间：2018-06-08 20:11:52
• 更新时间：2024-01-02 20:20:19
• Ciclesonide(RPR251526)是糖皮质素。

名称

• 中文名: 环索奈德
• 英文名: Ciclesonide
• 英文别名: 2-[(4aR,4bS,5S,6aS,6bS,8R,9aR,10aS,10bS)-8-Cyclohexyl-5-hydroxy-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,9a,10,10a,10b,11,12-dodecahydro-6bH-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-6b-yl]-2-oxoethyl-2-methylpropanoat; (R)-11b,16a,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione Cyclic 16,17-Acetal with Cyclohexanecarboxaldehyde 21-Isobutyrate; 2-méthylpropanoate de 2-[(4aR,4bS,5S,6aS,6bS,8R,9aR,10aS,10bS)-8-cyclohexyl-5-hydroxy-4a,6a-diméthyl-2-oxo-2,4a,4b,5,6,6a,9a,10,10a,10b,11,12-dodécahydro-6bH-naphto[2',1':4,5]indéno[1,2-d][1,3]dioxol-6b-yl]-2-oxoéthyle; Propanoic acid, 2-methyl-, 2-[(4aR,4bS,5S,6aS,6bS,8R,9aR,10aS,10bS)-8-cyclohexyl-2,4a,4b,5,6,6a,9a,10,10a,10b,11,12-dodecahydro-5-hydroxy-4a,6a-dimethyl-2-oxo-6bH-naphth[2',1':4,5]indeno[1,2-d][1,3]dioxol-6b-yl]-2-oxoethyl ester; 2-[(4aR,4bS,5S,6aS,6bS,8R,9aR,10aS,10bS)-8-Cyclohexyl-5-hydroxy-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,9a,10,10a,10b,11,12-dodecahydro-6bH-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-6b-yl]-2-oxoethyl 2-methylpropanoate; 2-méthylpropanoate de 2-[(4aR,4bS,5S,6aS,6bS,8R,9aR,10aS,10bS)-8-cyclohexyl-5-hydroxy-4a,6a-diméthyl-2-oxo-2,4a,4b,5,6,6a,9a,10,10a,10b,11,12-dodécahydro-6bH-naphto[2',1':4,5]indéno[1,2-d][1,3]dioxol-; Alvesco; Ciclesonide; propanoic acid, 2-methyl-, 2-[(4aR,4bS,5S,6aS,6bS,8R,9aR,10aS,10bS)-8-cyclohexyl-2,4a,4b,5,6,6a,9a,10,10a,10b,11,12-dodecahydro-5-hydroxy-4a,6a-dimethyl-2-oxo-6bH-naphth[2',1':4,5]indeno[1,2-d][1,3]di

物化性质

• 密度: 1.23 g/cm3
• 沸点: 665ºC at 760 mmHg
• 熔点: 202-209?C
• 分子式: C₃₂H₄₄O₇
• 分子量: 540.68800
• 闪点: 210ºC
• 精确质量: 540.30900
• PSA: 99.13000
• LogP: 4.70390
• 蒸汽压: 1.61E-20mmHg at 25°C
• 折射率: 1.575
• 储存条件: Refrigerator

生物活性

• 描述: Ciclesonide(RPR251526)是糖皮质素。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 糖皮质激素受体
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Mutch, E., et al., The role of esterases in the metabolism of ciclesonide to desisobutyryl-ciclesonide in human tissue. Biochem Pharmacol, 2007. 73(10): p. 1657-64.

  [2]. Barnes, N.C., The properties of inhaled corticosteroids: similarities and differences. Prim Care Respir J, 2007. 16(3): p. 149-54.

安全

• 海关编码: 2937229000

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