89785-84-2

• 常用中文名：他唑巴坦钠
• 常用英文名：Tazobactam Sodium Salt
• CAS号：89785-84-2
• 分子式：C₁₀H₁₁N₄NaO₅S
• 分子量：322.27300
• 相关类别： 原料药 抗生素类药物 β-内酰胺酶抑制剂
• 发布时间：2018-08-03 20:39:20
• 更新时间：2026-07-09 19:21:05
• Tazobactam sodium 是 β-内酰胺酶抑制剂类抗生素。Ceftolozane 与Tazobactam 联合应用,可提高头孢噻嗪对多种产 ESBL 肠杆菌科和部分类杆菌属的抗菌活性。

名称

• 中文名: 他唑巴坦钠
• 英文名: tazobactam sodium
• 中文别名: (2S,3S,5R)-3-((1H-1,2,3-三唑-1-基)甲基)-3-甲基-7-氧代-4-硫杂-1-氮杂双环[3.2.0]庚-2-羧酸钠4,4-二氧化物; [2S-(2a,3b,5a)]-3-甲基-7-氧代-3-(1H-1,2,3-三氮唑-1-基甲基)-4-硫代-1-氮杂双环[3,2,0]庚烷-2-羧酸钠 4,4-二氧化物; Tazobactam 他唑巴坦钠; 他唑巴坦酸钠盐; 他唑巴坦钠(无菌); 他唑巴坦-[13C2,15N3]钠盐; 他唑巴坦钠 [89-2]; 他唑巴坦钠盐; TAZOBACTAM SODIUM SALT,BETA-LACTAMASE抑制剂; 他唑巴坦钠 (标准品); TAZOBACTAM钠; 三唑巴坦钠; Tazobactam Sodium 他唑巴坦钠; 泰唑巴坦钠; Tazobactam Sodium/ 他唑巴坦钠/89-2; 冻干无菌粉
• 英文别名: Tazobactam sodium (usan); TAZOBACTAM SODIUM SALT; CL-298741 SODIUM SALT; Tazobactam Sodium Salt 1N; TazobactuM SodiuM; CL-30757; Tazobactam SodiumQ: What is Tazobactam Sodium Q: What is the CAS Number of Tazobactam Sodium Q: What is the storage condition of Tazobactam Sodium; CL-298741, YTR-830H, [2S-(2α, 3β, 5α)]-3-Methyl-7-oxo-3(1H,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]htane-2-cboxylic acid 4,4-dioxide; 3-Methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]htane-2-cboxylic acid 4,4-dioxidesodium salt; l^{6}-thia-1-azabicyclo[3.2.0]htane-2-cboxylate; D03707; Piperacillin sodium salt; Tazobactam-[13C2, 15N3] Sodium salt; Tazobactam sodium //BP; Caffeine Impurity 6-d3; triazol-1-ylmethyl)-,4,4-dioxide,sodiumsalt,(2s-(2-alpha,3-beta,5-alpha)); 4-thia-1-azabicyclo(3.2.0)htane-2-cboxylicacid,3-methyl-7-oxo-3-(1h-1,2,3; MFCD00917472; [2S-(2a,3b,5a)]-3-Methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide sodium salt; 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3-methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-, 4,4-dioxide, sodium salt, (2S,3S,5R)- (1:1); Tazobactam sodium salt; TAZOBACTAMACID/SODIUM; [2s-(2α,3β,5α)]-3-methyl-7-oxo-3(1h,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]htane-2-cboxylic acid 4,4-dioxide; Sodium (2S,3S,5R)-3-methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 4,4-dioxide; 3-methyl-7-oxo-3-(1h-1,2,3-triazol-1-ylmethyl)-,4,4-dioxide,sodiumsalt,(2s-(2-alpha,3-beta,5-alp4-thia-1-azabicyclo(3.2.0)htane-2-cboxylicaci; Sodium (2S,3S,5R)-3-((1H-1,2,3-triazol-1-yl)methyl)-3-methyl-7-oxo-4-thia-1-azabicyclo[3.2.0]htane-2-cboxylate 4,4-dioxide; Tazobactam sodium salt, beta-lactamase inhibitor; Tazobactam Sodium; 2-alpha-methyl-2-beta-(1,2,3-triazol-1-ylmethyl)penam-3-alpha-cboxylicacid; TazobactaM SodiuM API; Sodium (2S,3S,5R)-3-methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylate, 4,4-dioxide; (2S,3S,5R)-3-Methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]htane-2-cboxylic Acid 4,4-dioxide Sodium Salt; sodium 2β-<(1,2,3-triazol-1-yl)methyl>-2α-methylpenam-3α-cboxylate 1,1-dioxide; ytr830; sodium 3-methyl-4,4,7-trioxo-3-(1-triazolylmethyl)-4; (2S,3R,5R)-3-Methyl-7-oxo-2-sodiooxycbonyl-3-(1H-1,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]htane4,4-dioxide; TAZOBACTAM SODIUM; Sodium (2S, 3S, 5R)-3-methyl-7-oxo-3-(1H -1,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]htane-2-cboxylate-4,4-dioxide; (2S,3S,5R)-3-méthyl-7-oxo-3-(1H-1,2,3-triazol-1-ylméthyl)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate-4,4-dioxyde de sodium; [2s-(2a,3b,5a)]-3-methyl-7-oxo-3(1h,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]htane-2-cboxylic acid 4,4-dioxide sodium salt; cl307579; [2S-(2ALPHA, 3BETA, 5ALPHA)]-3-METHYL-7-OXO-3(1H,2,3-TRIAZOL-1-YLMETHYL)-4-THIA-1-AZABICYCLO[3.2.0]HTANE-2-CBOXYLIC ACID 4,4-DIOXIDE SODIUM SALT; YTR-830H SODIUM SALT; 4-Thia-1-azabicyclo[3.2.0]htane-2-cboxylicacid, 3-Methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylMethyl)-, 4,4-dioxide, sodiuM salt(1:1), (2S,3S,5R); CL 307,579

物化性质

• 密度: 1.92 g/cm3
• 沸点: 707.1ºC at 760 mmHg
• 熔点: 140-147ºC
• 分子式: C₁₀H₁₁N₄NaO₅S
• 分子量: 322.27300
• 闪点: 381.4ºC
• 精确质量: 322.03500
• PSA: 133.67000
• 储存条件: Store at 0-5°C
• 水溶解性: H2O: 50 mg/mL, clear, colorless

生物活性

• 描述: Tazobactam sodium 是 β-内酰胺酶抑制剂类抗生素。Ceftolozane 与Tazobactam 联合应用,可提高头孢噻嗪对多种产 ESBL 肠杆菌科和部分类杆菌属的抗菌活性。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 细菌
• 参考文献:

  [1]. Giacobbe DR, et al. Ceftolozane/tazobactam: place in therapy. Expert Rev Anti Infect Ther. 2018;16(4):307‐320.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : XI0191500 CHEMICAL NAME : 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3-methyl-7-oxo-3-(1H-1,2,3-triazol-1- ylmethyl)-, 4,4-dioxide, sodium salt, (2S-(2-alpha,3-beta,5-alpha))- CAS REGISTRY NUMBER : 89785-84-2 LAST UPDATED : 199409 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C10-H11-N4-O5-S.Na MOLECULAR WEIGHT : 322.30 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >5 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 11,588,1986

安全

• 个人防护装备: Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
• 危害码 (欧洲): Xi
• 风险声明 (欧洲): 36/37/38
• 安全声明 (欧洲): S22-S24/25
• 危险品运输编码: NONH for all modes of transport
• WGK德国: 3
• RTECS号: XI0191500
• 海关编码: 2934999090

合成路线

89789-07-1 ~% 89785-84-2

文献：Journal of Medicinal Chemistry, , vol. 30, # 8 p. 1469 - 1474

89786-04-9 61477-96-1 ~% 59703-84-3 89785-84-2

文献：EP1759697 A1, ; Page/Page column 2-3 ;

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89789-07-1 89786-04-9 61477-96-1
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海关

海关编码	2934999090
中文概述	2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%