88-32-4

• 常用中文名：2-叔丁基-4-羟基茴香醚
• 常用英文名：TBMP
• CAS号：88-32-4
• 分子式：C₁₁H₁₆O₂
• 分子量：180.24
• 相关类别： 化学农药原药 杀菌剂 唑类杀菌剂
• 发布时间：2018-02-27 08:00:00
• 更新时间：2026-08-15 12:35:04
• 3-tert-Butyl-4-methoxyphenol 是 alkyl/ethe 类 PROTAC linker,具有杀虫活性。3-tert-Butyl-4-methoxyphenol 还诱导 A/HeJ 小鼠的肝和前胃组织中谷胱甘肽 (GSH) S-转移酶和环氧化物水解酶的活性增加,调节致癌物代谢系统。

名称

• 中文名: 2-叔丁基-4-羟基茴香醚
• 英文名: 2-tert-butyl-4-hydroxyanisole
• 中文别名: 2-叔丁基-4-羟基苯甲醚检测标准品; 2-叔丁基-4-羟基茴香醚 标准品; BHA叔丁基对羟基茴香醚作用; BHA叔丁基对羟基茴香醚报价; 食品级BHA叔丁基对羟基茴香醚作用; BHA叔丁基对羟基茴香醚; 2-叔丁基-4-羟基茴香醚标准品; 食品级BHA叔丁基对羟基茴香醚; 食品级BHA叔丁基对羟基茴香醚报价; BHA叔丁基对羟基茴香醚; 丁基羟基苯甲醚杂质3(2-叔丁基-4-羟基苯甲醚); 丁羟基苯甲醚杂质3; 食品级BHA叔丁基对羟基茴香醚
• 英文别名: 4-Methoxy-3-te; 3-TERT-BUTYL-4-METHOXYPHENOL; 2-(1,1-DiMethylethyl)-4-hydroxyanisole; Butylhydroxyanisole Impurity 3（2-tert-Butyl-4-Hydroxyanisole）; 2-tert-Butyl-p-hydroxyanisole; 3-(1,1-DiMethylethyl)-4-Methoxyphenol; 2-tert-Butyl-4-hydroxyanisole-d3; 2-TERT-BUTYL-4-HYDROXYANISOLE; 2-T-BUTYL-4-HYDROXYANISOLE; tert-Butyl-3-methoxy-4-phenol; 3-tert-butyl-4-methoxy-pheno; Phenol, 3-tert-butyl-4-methoxy; Phenol, 3-(1,1-dimethylethyl)-4-methoxy; 4-Methoxy-3-(1,1-diMethylethyl)phenol; 4-methoxy; 2-TERT-BUTYLHYDROXYANISOLE; Phoratoxin B (reduced) 46; 3-tert-butylatedhydroxyanisole; 3-tert-Butylated hydroxyanisole; 2-BHA; 2-TERT-BUTYL-4-HYDROXYANISOLE / 3-TERT-BUTYL-4-METHOXYPHENOL; 2-tert-Butyl-4-hydroxyanisole; Butylhydroxyanisole Impurity 3; 4-Methoxy-3; 3-tert-Bha; TBMP, 10 mM in DMSO

物化性质

• 密度: 1.009 g/cm3
• 沸点: 293.3ºC at 760 mmHg
• 熔点: 64℃
• 分子式: C₁₁H₁₆O₂
• 分子量: 180.24
• 闪点: 136ºC
• 精确质量: 180.11500
• PSA: 29.46000
• LogP: 2.69830
• 外观性状: 固体
• 折射率: 1.507
• 储存条件: 库房通风低温干燥

生物活性

• 描述: 3-tert-Butyl-4-methoxyphenol 是 alkyl/ethe 类 PROTAC linker,具有杀虫活性。3-tert-Butyl-4-methoxyphenol 还诱导 A/HeJ 小鼠的肝和前胃组织中谷胱甘肽 (GSH) S-转移酶和环氧化物水解酶的活性增加,调节致癌物代谢系统。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 蛋白裂解靶向嵌合体 >> PROTAC Linker
• 参考文献:

  [1]. Lam LK, et al. Effects of 2- and 3-tert-butyl-4-hydroxyanisole on glutathione S-transferase and epoxide hydrolase activities and sulfhydryl levels in liver and forestomach of mice. Cancer Res. 1981 Oct;41(10):3940-3.

  [2]. Insecticide for vermin of order coleoptera. Japan, JP55136202 A 1980-10-23.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : SK1575010 CHEMICAL NAME : Phenol, 3-tert-butyl-4-methoxy- CAS REGISTRY NUMBER : 88-32-4 BEILSTEIN REFERENCE NO. : 2209222 LAST UPDATED : 199712 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C11-H16-O2 MOLECULAR WEIGHT : 180.27 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - hamster DOSE/DURATION : 27 gm/kg/3W-C TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors REFERENCE : JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 76,143,1986

安全

• 符号: GHS07
• 信号词: Warning
• 危害声明: H302-H319
• 警示性声明: P305 + P351 + P338
• 危害码 (欧洲): Xn
• 风险声明 (欧洲): 22-36
• 安全声明 (欧洲): 26
• 危险品运输编码: NONH for all modes of transport
• 海关编码: 2933990090

合成路线

21112-37-8 ~67% 88-32-4

文献：Synthesis, , # 8 p. 638 - 640

1948-33-0 ~% 88-32-4

文献：Journal of Medicinal Chemistry, , vol. 22, # 5 p. 569 - 571

77-78-1 1948-33-0 ~% 88-32-4

文献：WO2007/15260 A2, ; Page/Page column 7-9 ;

70020-84-7 ~% 88-32-4

文献：Journal of Medicinal Chemistry, , vol. 22, # 5 p. 569 - 571

70020-83-6 ~% 88-32-4

文献：Journal of Medicinal Chemistry, , vol. 22, # 5 p. 569 - 571

150-76-5 75-65-0 ~% 121-00-6 88-32-4

文献：US2616931 , ;

1991-52-2 ~% 88-32-4

文献：US2792427 , ;

150-76-5 115-11-7 ~% 88-32-4

文献：Fette und Seifen, , vol. 57, p. 656,658

1991-52-2 ~% 121-00-6 88-32-4 150-76-5

文献：US2792427 , ; US2676191 , ;

海关

海关编码	2909500000
中文概述	2909500000. 醚酚、醚醇酚及其卤化、磺化、硝化或亚硝化衍生物. 增值税率:17.0%. 退税率:9.0%. 监管条件:无. 最惠国关税:5.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途
Summary	2909500000 ether-phenols, ether-alcohol-phenols and their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%