6926-14-3

• 常用中文名：8-O-乙酰哈巴苷
• 常用英文名：8-O-Acetylharpagide
• CAS号：6926-14-3
• 分子式：C₁₇H₂₆O₁₁
• 分子量：406.382
• 相关类别： 天然产物 环烯醚萜衍生物
• 发布时间：2018-07-09 18:58:19
• 更新时间：2026-07-01 02:27:42
• 8-O-Acetylharpagide 是从 Ajuga reptans 中分离得到的一种环烯醚萜化合物,具有抗肿瘤、抗病毒、抗菌和抗炎活性。8-O-Acetylharpagide 对豚鼠离体平滑肌也有生物活性。

名称

• 中文名: 乙酰哈巴苷
• 英文名: 8-O-Acetylharpagide
• 中文别名: 3-乙酰哈巴苷, 来源于金疮小草; 8-乙酰化哈巴苷; 8-O-乙酰哈巴苷,10 MM DMSO 溶液; 8-O-乙酰基哈帕甙; ACETYLHPAGIDE 乙酰哈巴苷 标准品; 乙酰哈巴苷(8-O-乙酰哈巴苷); 8-O-Acetylhpagide8-O-乙酰哈巴苷; 乙酰哈巴苷(标准品); ACETYLHPAGIDE 乙酰哈巴苷; 乙酰哈巴苷对照品; (1S,4AS,5R,7S,7AS)-4A,5-二羟基-7-甲基-1-(((2S,3R,4S,5S,6R)-3,4,5-三羟基-6-(羟甲基)四氢-2H-吡喃-2-基)氧基)-1,4A,5,6,7,7A-六氢环戊并[C]吡喃-7-基 乙酸酯
• 英文别名: β-D-Glucopyranoside, (1S,4aS,5R,7S,7aS)-7-(acetyloxy)-1,4a,5,6,7,7a-hexahydro-4a,5-dihydroxy-7-methylcyclopenta[c]pyran-1-yl; (1S,4aS,5R,7S,7aS)-4a,5-Dihydroxy-7-methyl-1-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-7-yl acetate; (1S,4aS,5R,7S,7aS)-1-(β-D-Glucopyranosyloxy)-4a,5-dihydroxy-7-methyl-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-7-yl acetate; 8-O-Acetylhpagide, 10 mM in DMSO; 8-O-Acetylhpagide Acetylhpagi; Uric acid,1,3-dimethyl-8-propylthio-6-thio; (1S,4aS,5R,7S,7aS)-1-(hexopyranosyloxy)-4a,5-dihydroxy-7-Methyl-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-7-ylacetate; 3-Acetylhpagide from Ajuga decumbens Thunb; (1S,4aS,5R,7S,7aS)-1-(hexopyranosyloxy)-4a,5-dihydroxy-7-met; 3-Acetylhpagide; beta-D-Glucopyranoside, (1S,4aS,5R,7S,7aS)-7-(acetyloxy)-1,4a,5,6,7,7a-hexahydro-4a,5-dihydroxy-7-methylcyclopenta[c]pyran-1-yl; Acetylhpagide(8-O-Acetylhpagide); 8-O-Acetylhpagide Acetylhpagide; 6-Thio-8-propylthiotheophylline; 8-Acetylhpagide-RM; 8-O-acetyl-harpagide; ACETYLHPAGIDE, 8-O; Harpagide 7-acetyl; ACETYLHPAGIDE, 8-O-(P); 8-n-Propylthio-6-thiotheophyllin; 8-O-acetylhpagide; Hpagide 7-acetate; b-D-Glucopyranoside,(1S,4aS,5R,7S,7aS)-7-(acetyloxy)-1,4a,5,6,7,7a-hexahydro-4a,5-dihydroxy-7-methylcyclopenta[c]pyran-1-yl

物化性质

• 密度: 1.6±0.1 g/cm3
• 沸点: 607.2±55.0 °C at 760 mmHg
• 熔点: 227-229℃
• 分子式: C₁₇H₂₆O₁₁
• 分子量: 406.382
• 闪点: 215.9±25.0 °C
• 精确质量: 406.147522
• PSA: 175.37000
• LogP: -3.48
• 蒸汽压: 0.0±3.9 mmHg at 25°C
• 折射率: 1.624
• 储存条件: ?20°C

生物活性

• 描述: 8-O-Acetylharpagide 是从 Ajuga reptans 中分离得到的一种环烯醚萜化合物,具有抗肿瘤、抗病毒、抗菌和抗炎活性。8-O-Acetylharpagide 对豚鼠离体平滑肌也有生物活性。
• 相关类别:
  研究领域 >> 癌症
  研究领域 >> 感染
  信号通路 >> 其他 >> 其他
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Wen B, et al. Pharmacokinetics of 8-O-acetylharpagide and harpagide after oral administration of Ajuga decumbens Thunb extract in rats. J Ethnopharmacol. 2013 May 20;147(2):503-8.

  [2]. Breschi MC, et al. Vasoconstrictor activity of 8-O-acetylharpagide from Ajuga reptans. J Nat Prod. 1992 Aug;55(8):1145-8.

安全

• 安全声明 (欧洲): 24/25
• 危险品运输编码: NONH for all modes of transport