53760-19-3

• 常用中文名：细胞松驰素 H
• 常用英文名：Cytochalasin H
• CAS号：53760-19-3
• 分子式：C₃₀H₃₉NO₅
• 分子量：493.63
• 相关类别： 原料药 抗生素类药物 其它抗生素类药
• 发布时间：2018-07-01 19:11:10
• 更新时间：2024-01-02 11:41:34
• 细胞凝集素H是从真菌Phomopsis sp.中分离得到的天然产物。细胞凝集素H抑制细胞生长并诱导细胞凋亡。细胞松弛素H具有抗血管生成活性。细胞松弛素H是一种抗生素,具有抗菌活性[1][2][3]。

名称

• 中文名: 细胞松弛素H
• 英文名: cytochalasin h
• 中文别名: 细胞松驰素 H
• 英文别名: <11>Cytochalasin; paspalin; 19-triene-1-one; cytochalasin U; paspalinpi; Paspalin P1; cytochalasinhfromphomopsissp.; kodocytochalasin-1

物化性质

• 密度: 1.19g/cm3
• 沸点: 676.5ºC at 760mmHg
• 熔点: 252-258ºC
• 分子式: C₃₀H₃₉NO₅
• 分子量: 493.63
• 闪点: 362.9ºC
• 精确质量: 493.28300
• PSA: 95.86000
• LogP: 4.06690
• 折射率: 1.591
• 储存条件: 2-8°C
• 水溶解性: chloroform: 10 mg/mL, clear, colorless

生物活性

• 描述: 细胞凝集素H是从真菌Phomopsis sp.中分离得到的天然产物。细胞凝集素H抑制细胞生长并诱导细胞凋亡。细胞松弛素H具有抗血管生成活性。细胞松弛素H是一种抗生素,具有抗菌活性[1][2][3]。
• 相关类别:
  信号通路 >> 细胞凋亡 >> Bcl-2家族
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  研究领域 >> 癌症
  研究领域 >> 感染
  信号通路 >> 细胞凋亡 >> 胱天蛋白酶
  信号通路 >> 抗感染 >> 细菌
• 体外研究: 细胞松弛素H(24-72小时)抑制 A549细胞的增殖,IC50值为 159.5µM[1]细胞松弛素H(0-50µM；48小时)在 A549细胞中诱导细胞凋亡,使细胞周期停滞在 G2/M期,并影响细胞凋亡相关蛋白的表达[1] 细胞松弛素H(1-512μg/mL)对 多学科研究肠道致病菌、革兰氏阳性菌和金黄色葡萄球菌具有抗菌活性[3] 细胞凋亡分析[1]细胞系：A549细胞浓度：0、6.25、12.5、25和50µM培养时间：48小时结果：以剂量依赖性方式诱导A549细胞凋亡。细胞周期分析[1]细胞系：A549细胞浓度：0、6.25、12.5、25和50µM培养时间：48小时结果：细胞周期停滞在G2/M期和亚G1期峰值。Western Blot分析[1]细胞系：A549细胞浓度：0、6.25、12.5、25和50µM孵育时间：48小时结果：增加Bax、P53和裂解的胱天蛋白酶3的蛋白表达水平,降低Bcl-xL、Bcl-2和全长胱天蛋白酶-3的蛋白表达量。
• 体内研究: 细胞松弛素H(2.5 mg/kg；腹腔注射)可以延迟 余额/cnu/nu小鼠中 A549异种移植肿瘤的生长[2] 动物模型：雄性Balb/cnu/nu小鼠A549异种移植物[2]剂量：2.5 mg/kg给药：腹腔注射；3次注射/周,持续80天结果：体内肿瘤生长减弱。
• 参考文献:

  [1]. Ma Y, et, al. Cytochalasin H isolated from mangrove‑derived endophytic fungus induces apoptosis and inhibits migration in lung cancer cells. Oncol Rep. 2018 Jun;39(6):2899-2905.

  [2]. Yi JM, et, al. In Vivo Anti-tumor Effects of the Ethanol Extract of Gleditsia sinensis Thorns and Its Active Constituent, Cytochalasin H. Biol Pharm Bull. 2015;38(6):909-12.

  [3]. Jouda JB, et, al. Antibacterial and cytotoxic cytochalasins from the endophytic fungus Phomopsis sp. harbored in Garcinia kola (Heckel) nut. BMC Complement Altern Med. 2016 Nov 14;16(1):462.

MSDS

SECTION 1: Identification of the substance/mixture and of the company/undertaking Product identifiers Product name: Cytochalasin H, from Phomopsis sp. REACH No.: A registration number is not available for this substance as the substance or its uses are exempted from registration, the annual tonnage does not require a registration or the registration is envisaged for a later registration deadline. CAS-No.: 53760-19-3 SECTION 2: Hazards identification Classification of the substance or mixture Classification according to Regulation (EC) No 1272/2008 Acute toxicity, Inhalation (Category 1), H330 Acute toxicity, Dermal (Category 2), H310 Acute toxicity, Oral (Category 2), H300 Reproductive toxicity (Category 2), H361 For the full text of the H-Statements mentioned in this Section, see Section 16. Classification according to EU Directives 67/548/EEC or 1999/45/EC T+ Very toxicR26/27/28, R63 For the full text of the R-phrases mentioned in this Section, see Section 16. Label elements Labelling according Regulation (EC) No 1272/2008 Pictogram Signal wordDanger Hazard statement(s) Fatal if swallowed. Fatal in contact with skin. Fatal if inhaled. Suspected of damaging fertility or the unborn child. Precautionary statement(s) Do not breathe dust/ fume/ gas/ mist/ vapours/ spray. Wash hands thoroughly after handling. Wear protective gloves/ protective clothing. Wear respiratory protection. P302 + P350IF ON SKIN: Gently wash with plenty of soap and water. Immediately call a POISON CENTER or doctor/ physician. Supplemental Hazardnone Statements Other hazards - none SECTION 3: Composition/information on ingredients Substances Chemical characterization : Natural product Formula: C30H39NO5 Molecular Weight: 493,63 g/mol CAS-No.: 53760-19-3 Hazardous ingredients according to Regulation (EC) No 1272/2008 ComponentClassificationConcentration Cytochalasin H from Phomopsis sp CAS-No.53760-19-3Acute Tox. 1; Acute Tox. 2;<= 100 % Repr. 2; H300, H310, H330, Hazardous ingredients according to Directive 1999/45/EC ComponentClassificationConcentration Cytochalasin H from Phomopsis sp CAS-No.53760-19-3T+, R26/27/28 - R63<= 100 % For the full text of the H-Statements and R-Phrases mentioned in this Section, see Section 16 SECTION 4: First aid measures Description of first aid measures General advice Consult a physician. Show this safety data sheet to the doctor in attendance. If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Take victim immediately to hospital. Consult a physician. In case of eye contact Flush eyes with water as a precaution. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician. Most important symptoms and effects, both acute and delayed The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11 Indication of any immediate medical attention and special treatment needed no data available SECTION 5: Firefighting measures Extinguishing media Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Special hazards arising from the substance or mixture Carbon oxides, nitrogen oxides (NOx) Advice for firefighters Wear self contained breathing apparatus for fire fighting if necessary. Further information no data available SECTION 6: Accidental release measures Personal precautions, protective equipment and emergency procedures Wear respiratory protection. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Environmental precautions Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Methods and materials for containment and cleaning up Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal. Reference to other sections For disposal see section 13. SECTION 7: Handling and storage Precautions for safe handling Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed.Normal measures for preventive fire protection. For precautions see section 2.2. Conditions for safe storage, including any incompatibilities Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: 2 - 8 °C Specific end use(s) Apart from the uses mentioned in section 1.2 no other specific uses are stipulated SECTION 8: Exposure controls/personal protection Control parameters Components with workplace control parameters Exposure controls Appropriate engineering controls Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling the product. Personal protective equipment Eye/face protection Face shield and safety glasses Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Full contact Material: Nitrile rubber Minimum layer thickness: 0,11 mm Break through time: 480 min Splash contact Material: Nitrile rubber Minimum layer thickness: 0,11 mm Break through time: 480 min test method: EN374 If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an industrial hygienist and safety officer familiar with the specific situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario. Body Protection Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Respiratory protection Where risk assessment shows air-purifying respirators are appropriate use a full-face particle respirator type N100 (US) or type P3 (EN 143) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU). Control of environmental exposure Prevent further leakage or spillage if safe to do so. Do not let product enter drains. SECTION 9: Physical and chemical properties Information on basic physical and chemical properties a) AppearanceForm: crystalline Colour: white b) Odourno data available c) Odour Thresholdno data available d) pHno data available e) Melting point/freezingMelting point/range: 254 - 258 °C point f) Initial boiling point and no data available boiling range g) Flash pointno data available h) Evapouration rateno data available i) Flammability (solid, gas) no data available j) Upper/lowerno data available flammability or explosive limits k) Vapour pressureno data available l) Vapour densityno data available m) Relative densityno data available n) Water solubilityno data available o) Partition coefficient: n- no data available octanol/water p) Auto-ignitionno data available temperature q) Decompositionno data available temperature r) Viscosityno data available s) Explosive propertiesno data available t) Oxidizing propertiesno data available Other safety information no data available SECTION 10: Stability and reactivity Reactivity no data available Chemical stability Stable under recommended storage conditions. Possibility of hazardous reactions no data available Conditions to avoid no data available Incompatible materials Strong oxidizing agents, Strong bases Hazardous decomposition products Other decomposition products - no data available In the event of fire: see section 5 SECTION 11: Toxicological information Information on toxicological effects Acute toxicity no data available Skin corrosion/irritation no data available Serious eye damage/eye irritation no data available Respiratory or skin sensitisation no data available Germ cell mutagenicity Human lymphocyte Cytogenetic analysis Carcinogenicity IARC:No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC. Reproductive toxicity Suspected human reproductive toxicant Overexposure may cause reproductive disorder(s) based on tests with laboratory animals. Specific target organ toxicity - single exposure no data available Specific target organ toxicity - repeated exposure no data available Aspiration hazard no data available Additional Information RTECS: HA5306000 SECTION 12: Ecological information Toxicity no data available Persistence and degradability no data available Bioaccumulative potential no data available Mobility in soil no data available Results of PBT and vPvB assessment PBT/vPvB assessment not available as chemical safety assessment not required/not conducted Other adverse effects no data available SECTION 13: Disposal considerations Waste treatment methods Product Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. Contaminated packaging Dispose of as unused product. SECTION 14: Transport information UN number ADR/RID: 3462IMDG: 3462IATA: 3462 UN proper shipping name ADR/RID: TOXINS EXTRACTED FROM LIVING SOURCES, SOLID, N.O.S. (Cytochalasin H from Phomopsis sp) IMDG: TOXINS, EXTRACTED FROM LIVING SOURCES, SOLID, N.O.S. (Cytochalasin H from Phomopsis sp) IATA:Toxins, extracted from living sources, solid, n.o.s. (Cytochalasin H from Phomopsis sp) Transport hazard class(es) ADR/RID: 6.1IMDG: 6.1IATA: 6.1 Packaging group ADR/RID: IIIMDG: IIIATA: II Environmental hazards ADR/RID: noIMDG Marine pollutant: noIATA: no Special precautions for user no data available SECTION 15: Regulatory information This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006. Safety, health and environmental regulations/legislation specific for the substance or mixture no data available Chemical Safety Assessment SECTION 16 - ADDITIONAL INFORMATION N/A

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : HA5306000 CHEMICAL NAME : (11)Cytochalasa-6(12),13,19-trien-1-one, 21-(acetyloxy)-7,18-dihydroxy-16,18-dimethyl-10- phenyl-, (7S,13E,16S,18S,19E,21R)- CAS REGISTRY NUMBER : 53760-19-3 LAST UPDATED : 199107 DATA ITEMS CITED : 5 MOLECULAR FORMULA : C30-H39-N-O5 MOLECULAR WEIGHT : 493.70 WISWESSER LINE NOTATION : T56-11- 1A R AXVM GY JU PUTJ D1R& F1 GU1 HQ M1 OQ O1 ROV1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 2 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 2 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Bird - chicken DOSE/DURATION : 12500 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Mammal - species unspecified DOSE/DURATION : 2341 ug/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - ptosis Behavioral - changes in motor activity (specific assay) Behavioral - ataxia MUTATION DATA TYPE OF TEST : Cytogenetic analysis TEST SYSTEM : Human Lymphocyte DOSE/DURATION : 500 ug/L REFERENCE : IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 16,430,1978

安全

• 符号: GHS06, GHS08
• 信号词: Danger
• 危害声明: H300-H310-H330-H361
• 警示性声明: P260-P264-P280-P284-P302 + P350-P310
• 个人防护装备: Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
• 危害码 (欧洲): T+
• 风险声明 (欧洲): 26/27/28-63
• 安全声明 (欧洲): 28-36/37-45
• 危险品运输编码: UN 3462 6.1/PG 2
• WGK德国: 3
• RTECS号: HA5306000
• 包装等级: I
• 危险类别: 6.1(a)

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