5560-72-5

• 常用中文名：伊普吲哚
• 常用英文名：Iprindole
• CAS号：5560-72-5
• 分子式：C₁₉H₂₈N₂
• 分子量：284.43900
• 相关类别： 信号通路 G 蛋白偶联受体/G 蛋白 5-HT受体
• 发布时间：2018-06-11 17:20:25
• 更新时间：2024-01-10 14:59:52
• Iprindole 具有抗抑郁的生物活性,是一种弱的去甲肾上腺素和5-HT 摄取的抑制剂。

名称

• 中文名: 伊普吲哚
• 英文名: 3-(6,7,8,9,10,11-hexahydrocycloocta[b]indol-5-yl)-N,N-dimethylpropan-1-amine
• 英文别名: Prondol; Iprindole; Galatur; Pramindole; WY-3263; Tertran

物化性质

• 密度: 1.04g/cm3
• 沸点: 435.4ºC at 760mmHg
• 分子式: C₁₉H₂₈N₂
• 分子量: 284.43900
• 闪点: 217.1ºC
• 精确质量: 284.22500
• PSA: 8.17000
• LogP: 4.25200
• 外观性状: 油状物
• 折射率: 1.573
• 储存条件: 2-8°C，密封，干燥

生物活性

• 描述: Iprindole 具有抗抑郁的生物活性,是一种弱的去甲肾上腺素和5-HT 摄取的抑制剂。
• 相关类别:
  研究领域 >> 代谢疾病
  研究领域 >> 神经疾病
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体
  信号通路 >> 神经信号通路 >> 5-HT受体
• 体内研究: 依哌利多对去甲肾上腺素和5-羟色胺摄取的抑制作用小于50%,剂量为100 mg/kg。。
• 参考文献:

  [1]. M I Gluckman, et al. The pharmacology of iprindole, a new antidepressant. Psychopharmacologia. 1969;15(3):169-85.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : GY0350000 CHEMICAL NAME : 5H-Cyclooct(b)indole, 5-(3-(dimethylamino)propyl)-6,7,8,9,10,11-hexahydro- CAS REGISTRY NUMBER : 5560-72-5 LAST UPDATED : 199712 DATA ITEMS CITED : 5 MOLECULAR FORMULA : C19-H28-N2 MOLECULAR WEIGHT : 284.49 WISWESSER LINE NOTATION : T B658 HN&&TJ H3N1&1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 775 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 18,185,1971 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 187 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,130,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 484 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 18,185,1971 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 195 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,130,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 32 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#01206

合成路线

1556-09-8 369-57-3 109-54-6 ~72% 5560-72-5

文献：Zhang, Zhi-Guang; Haag, Benjamin A.; Li, Jin-Shan; Knochel, Paul Synthesis, 2011 , # 1 p. 23 - 29

109-54-6 22793-63-1 ~% 5560-72-5

文献：Zhu, Can; Zhang, Xue; Lian, Xiongdong; Ma, Shengming Angewandte Chemie - International Edition, 2012 , vol. 51, # 31 p. 7817 - 7820

1401315-71-6 ~% 5560-72-5

文献：Zhu, Can; Zhang, Xue; Lian, Xiongdong; Ma, Shengming Angewandte Chemie - International Edition, 2012 , vol. 51, # 31 p. 7817 - 7820

1402424-10-5 ~% 5560-72-5

文献：Zhu, Can; Zhang, Xue; Lian, Xiongdong; Ma, Shengming Angewandte Chemie - International Edition, 2012 , vol. 51, # 31 p. 7817 - 7820

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