105454-04-4

• 常用中文名：7-表紫杉醇
• 常用英文名：7-Epitaxol
• CAS号：105454-04-4
• 分子式：C₄₇H₅₁NO₁₄
• 分子量：853.906
• 相关类别： 生物化工 植物提取物
• 发布时间：2018-02-06 08:00:00
• 更新时间：2026-07-01 15:27:04
• 7-epi-Taxol 是 taxol 的活性代谢物,在抑制细胞增殖及微管 (microtubule) 解离,诱导微管聚合等方面与 taxol 作用相当。

名称

• 中文名: 7-表紫杉醇
• 英文名: 7-Epitaxol
• 中文别名: 紫杉醇杂质E(7-表紫杉醇); 7-表紫杉醇,10 MM DMSO 溶液; 表紫杉醇; 7-表紫杉醇/HPLC; 紫杉醇杂质Ⅲ（7-表-紫杉醇）(2 ,4R ,4aS ,6R ,9S , llS ,12,12bS )- l ,2a ,3 ,4 ,4a ,6 ,9，10，11，12，12a，12b)-十二氢-4，6，9，11，12，12b-六羟基-4a，8，13，13-四甲基-7，11-亚甲基-5H-环芳癸[ 3，4 ]苯并[ 1，2-b]氧杂环丁烷-5酮-6，12b-二醋酸酯，12-苯甲酸酯，9-(2R,3S) -N-苯甲酰-3-苯基异丝氨酸酯; 紫杉醇杂质Ⅲ(7-表-紫杉醇)(2 ,4R ,4AS ,6R ,9S , LLS ,12,12BS )- L ,2A ,3 ,4 ,4A ,6 ,9,10,11,12,12A,12B)-十二氢-4,6,9,11,12,12B-六羟基-4A,8,13,13-四甲基-7,11-亚甲基-5H-环芳癸[ 3,4 ]苯并[ 1,2-B]氧杂环丁烷-5酮-6,12B-二醋酸酯,12-苯甲酸酯,9-(2R,3S) -N-苯甲酰-3-苯基异丝氨酸酯; 紫杉醇杂质E(7- I紫杉醇); 紫杉醇; 紫杉醇杂质E; 7-表紫杉醇(标准品); 7-I紫杉醇; 紫杉醇杂质5(紫杉醇杂质E); 7-表皮素; 7-差向紫杉醇; (2,4R,4aS,6R,9S,11S,12S,12,12bS)-9-(((2R,3S)-3-苯甲酰胺-2-羟基-3-苯基丙酰基)氧基)-12-(苯甲酰氧基)-4,11-二羟基-4a,8,13,13-四甲基-5-氧代-3,4,4a,5,6,9,10,11,12,12a-十氢-1H-7,11-甲桥环癸并[3,4]苯并[1,2-b]oxete-6,12b(2aH)-二基 二乙酸酯; 7-表-紫杉醇(紫杉醇杂质III); 紫杉醇杂质; 紫杉醇杂质III; 7-表紫杉醇(对照品); 7-表紫杉醇,7-差向紫杉醇; 紫杉醇杂质E(7-差向紫杉醇); 7-表紫杉醇, 来源于红豆杉; 7-差向紫杉酚; 7-表位紫杉醇(紫杉醇杂质E)
• 英文别名: ITAXOL,7- SOLUTION(2.4mg/mL)(P); Paclitaxel Impurity 5（Paclitaxel Impurity E）; inhibit,Microtubule/Tubulin,7 i Taxol,7iTaxol,Inhibitor; (2α,5β,7α,10β,13α)-4,10-Diacetoxy-13-{[(2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoyl]oxy}-1,7-dihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate; 5b,20-Epoxy-1,2a,4,7b,10b,13a-hexahydroxytax-11-en-9-one 4,10-Diacetate 2-Benzoate 13-Ester with (2R,3S)-N-Benzoyl-3-phenylisoserine; Yewtaxan; Paclitaxel Impurity E; benzenepropanoic acid, beta-(benzoylamino)-alpha-hydroxy-, 6,12B-bis(acetyloxy)-12-(benzoyloxy)-2A,3,4,4A,5,6,9,10,11,12,12A,12B-dodecahydro-4,11-dihydroxy-4A,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-B)oxet-9-yl ester, (2- (2aalpha,4alpha,4abeta,6beta,9alpha(alph*,betas*),11alpha,12alpha,12aalpha,12balpha)); TaxAlbin; Paclitaxel Impurity Ⅲ:(7-i-Paclitaxel); Paclitaxel 7-i-Impurity; Epitaxol; (1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-Bis(acetyloxy)-1,9-dihydroxy-15-({(2R,3S)-2-hydroxy-3-phenyl-3-[(phenylcarbonyl)amino]propanoyl}oxy)-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.0.0]heptadec-13-en-2-ylbenzolcarboxylat; 7-i-Taxol, 10 mM in DMSO; Taxol A; 7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete benzenepropanoic acid derivative; Paclitaxel Impurity E (7-Diverse Taxol); 7-i-Paclitaxel(7-itaxol); (2,4R,4aS,6R,9S,11S,12S,12,12bS)-9-(((2R,3S)-3-Benzamido-2-hydroxy-3-phenylpropanoyl)oxy)-12-(benzoyloxy)-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-3,4,4a,5,6,9,10,11,12,12a-decahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxete-6,12b(2aH)-diyl diacetate; benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, [2-[2aα,4α,4aβ,6β; 7-epi-Taxol; 7-itaxol 7-ipaclitaxel; (2α,5β,7β,10β,13α)-4,10-bis(acetyloxy)-1,7-dihydroxy-13-({(2R,3S)-2-hydroxy-3-phenyl-3-[(phenylcarbonyl)amino]propanoyl}oxy)-9-oxo-5,20-epoxytax-11-en-2-yl benzoate; UNII-P88XT4IS4D; Paclitaxel Impurity E (7-i Paclitaxel); (1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-bis(acetyloxy)-1,9-dihydroxy-15-({(2R,3S)-2-hydroxy-3-phenyl-3-[(phenylcarbonyl)amino]propanoyl}oxy)-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.0.0]heptadec-13-en-2-yl benzoate; 7-ipaclitaxel, froM Taxus chinensis; BMS 181339-01; 7-i Paclitaxel (Paclitaxel Impurity E); itaxol; Plaxicel; Paxceed; benzenepropanoic acid, beta-(benzoylamino)-alpha-hydroxy-, (2,4R,4as,6R,9S,11S,12S,12,12bs)-6,12B-bis(acetyloxy)-12-(benzoyloxy)- 2A,3,4,4A,5,6,9,10,11,12,12A,12B-dodecahydro-4,11-dihydroxy-4A,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-B)oxet-9-yl ester, (alph,betas); (2a,5b,7b,10b,13a)-4,10-bis(acetyloxy)-13-{[(2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoyl]oxy}-1,7-dihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate; (2α,5β,7β,10β,13α)-4,10-Diacetoxy-13-{[(2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoyl]oxy}-1,7-dihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate; 7-ipaclitaxel(crude); Paclitaxel; (2,4R,4aS,6R,9S,11S,12S,12,12bS)-9-(((2R,3S)-3-benzamido-2-hydroxy-3-phenylpropanoyl)oxy)-12-(benzoyloxy)-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1; 7-ipaclitaxelQ: What is 7-ipaclitaxel Q: What is the CAS Number of 7-ipaclitaxel Q: What is the storage condition of 7-ipaclitaxel Q: What e the applications of 7-ipaclitaxel; 7-itaxol ，S9265; 7-ipaclitaxel from Taxus chinensis (Pilg.) Rehder; Propanedioicacid,2-(2-propyn-6-yl)-,diethylester; Peclitaxel; Taxol; ITAXOL, 7; Paxene; Paclitaxel Imp. I : 10-O-[(2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoyl]-10-O-deacetylpaclitaxel; benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, (2,4R,4aS,6R,9S,11S,12S,12,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS); benzenepropanoicacid,beta-(benzoylaMino)-alpha-hydroxy-,6,12B-bis(acetyloxy)-12-(benzoyloxy)-2A,3,4,4A,5,6,9,10,11,12,12A,12B-dodecahydro-4,11-dihydroxy-4A,8,13,13-tetraMethyl-5-oxo-7,11-Methano-1H-cyclodeca(3,4)benz(1,2-B)oxet-9-ylester,(2-(; 7-i-Taxol, Metabolite of Paclitaxel; 7-IPACLITAXEL; 7-ITAXOL; 7-I-PACLITAXEL; ITAXOL; LipoPac; 7-Epi Paclitaxel; Ebetaxel; Anzatax; baccatin III N-benzyl-b-phenylisoserine ester; Onxol; (2,4R,4aS,6R,9S,11S,12S,12,12bS)-9-(((2R,3S)-3-benzamido-2-hydroxy-3-phenylpropanoyl)oxy)-12-(benzoyloxy)-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxete-6,12b-diyl diacetate

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 957.1±65.0 °C at 760 mmHg
• 熔点: 168-170?C
• 分子式: C₄₇H₅₁NO₁₄
• 分子量: 853.906
• 闪点: 532.6±34.3 °C
• 精确质量: 853.330933
• PSA: 221.29000
• LogP: 7.38
• 外观性状: 粉末
• 蒸汽压: 0.0±0.3 mmHg at 25°C
• 折射率: 1.637
• 储存条件: -20°C Freezer, Under Inert Atmosphere

生物活性

• 描述: 7-epi-Taxol 是 taxol 的活性代谢物,在抑制细胞增殖及微管 (microtubule) 解离,诱导微管聚合等方面与 taxol 作用相当。
• 相关类别:
  信号通路 >> 细胞周期/DNA损伤 >> 微管/微管蛋白
  信号通路 >> 细胞骨架 >> 微管/微管蛋白
  研究领域 >> 癌症
  天然产物 >> 萜类化合物和糖苷
• 靶点:

  Microtubule/Tubulin[2]

• 体外研究: 7-epi-Taxol(7-Epitaxol)是紫杉醇的代谢产物[1]。 7-epi-Taxol具有与紫杉醇相当的活性,可用于细胞复制,微管束形成和体外微管聚合[2]。
• 参考文献:

  [1]. Royer I, et al. Paclitaxel metabolites in human plasma and urine: identification of 6 alpha-hydroxytaxol, 7-epitaxol and taxol hydrolysis products using liquid chromatography/atmospheric-pressure chemical ionization mass spectrometry. Rapid Commun Mass Spectrom. 1995;9(6):495-502.

  [2]. Ringel I, et al. Taxol is converted to 7-epitaxol, a biologically active isomer, in cell culture medium. J Pharmacol Exp Ther. 1987 Aug;242(2):692-8.

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