4093-29-2

• 常用中文名：胃复安甲基物
• 常用英文名：Methyl 4-acetamido-2-methoxybenzoate
• CAS号：4093-29-2
• 分子式：C₁₁H₁₃NO₄
• 分子量：223.225
• 相关类别： 分析化学 标准品 药典标准品和杂志标准品
• 发布时间：2018-10-17 10:39:46
• 更新时间：2026-07-12 15:07:01
• 【用途一】
  胃复安的中间体。

名称

• 中文名: 胃复安甲基物
• 英文名: Methyl 4-acetamido-2-methoxybenzoate
• 中文别名: 甲氧氯普胺相关复合物D; 2-甲氧基-4-乙酰胺基苯甲酸甲酯; 4-乙酰氨基-2-甲氧基苯甲酸甲酯:胃复安甲基物; 4-乙酰胺基-邻茴香酸甲酯; 甲氧氯普胺杂质4 (甲氧氯普胺杂质D); 甲氧氯普胺BP杂质D; 盐酸甲氧氯普胺杂质D; 4-乙酰氨基-2-甲氧基苯甲酸甲酯; 酒石酸西尼必利杂质34; 2-甲氧基-4-乙酰胺基苯甲酸甲酯 (甲氧氯普胺甲基物); 甲氧氯普胺相关化合物D; 甲氧氯普胺杂质 04; 盐酸甲氧氯普胺杂质D 标准品; 4-乙酰胺基-2-甲氧基苯甲酸甲酯; 甲氧氯普安相关物质D; 4-乙酰胺基-2-甲氧基苯甲酸甲酯(甲氧氯普胺杂质); 4-乙酰胺-2-甲氧基苯甲酸甲酯; 对乙酰氨基-邻甲氧基苯甲酸甲酯; 甲氧氯普胺杂质D(胃复安相关化合物D); 甲基 4-乙酰胺基-2-甲氧基苯甲酸酯; 胃复安杂质D; 甲基 4-(乙酰氨基)-2-甲氧基苯甲酸酯; 乙酰氨基-2-甲氧基苯甲酸甲酯; 甲氧氯普胺杂质D
• 英文别名: Methyl4-acetylamino-2-methoxybenzoate; methyl 4-(acetylamino)-o-anisate; Methyl-4-acetylaMino-2-Methoxybenzoate (Methyl-4-acetaMido-o-anisate); 4-(acetylamino)-2-methoxy-Benzoic acid methyl ester (9CI ACI); Cinibide Ttic acid impurity 34; 4-acetyloxy-2-methoxybenzoic acid methyl ester; MetoclopraMide Related CoMpound D; Metoclopramide Impurity D (Metoclopramide Related Compound D); 4-(acetylamino)-2-methoxy-benzoic acid,methyl ester; Methyl4-acetamido-2-methoxybenzoate(MetoclopramideImpurity); Metoclopramide RC D; METHYL 4-ACETAMIDO-2-METHOXYBENZOATE; methyl 2-methoxy-4-acetamidobenzoate; Metoclopramide Impurity D; Benzoic acid,4-(acetylamino)-2-methoxy-, methyl ester; EINECS 223-839-6; Benzoic acid, 4-(acetylamino)-2-methoxy-, methyl ester (9CI, ACI); Metoclopramide Hydrochloride Monohydrate Impurity D; 4-acetamido-2-methoxybenzoic acid methyl ester; Metoclopramide Related Compound D (methyl 4-acetamido-2-methoxybenzoate); Benzoic acid, 4-(acetylamino)-2-methoxy-, methyl ester; MetocloprDmide Impurity D; Methyl - 4 - Acetamido - 2 – Methoxy Benzoate(Methopabate); 4-ACETYLAMINO-2-METHOXY-BENZOIC ACID METHYL ESTER; METHYL4-ACETAMINO-2-METHOXYBENZOATE; METHYL 4-ACETAMIDO-2-METHOXYBENZOATE 4-2; 4-ACETAMIDO-2-METHOXYBENZOIC ACID METHYL ESTER (METHOPABATE); Metoclopramide Impurity 4（Metoclopramide Impurity D）; 4-Acetamido-o-anisic Acid Methyl Ester; Methyl 4-Acetamido-o-anisate; 4-acetamide-2-methoxybenzoicacid-methylester; 4-ACETYLAMINO-2-METHOXYBENZOATE; Methyl 4-(Acetylamino)-2-methoxyben; methyl-4-acetamido-2-methoxybenzoate; 4-ACETAMIDO-2-METHOXYBENZOIC ACID METHYL ESTER; Metoclopramide BP Impurity D; Metoclopramide related Complex D; Metoclopramide Impurity DQ: What is Metoclopramide Impurity D Q: What is the CAS Number of Metoclopramide Impurity D Q: What is the storage condition of Metoclopramide Impurity D Q: What e the applications of Metoclopramide Impurity D; MFCD00065258; methyl 4-(acetylamino)-2-methoxybenzoate; 2-Methoxy-4-acetylaMino Methyl benzoate

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 417.5±35.0 °C at 760 mmHg
• 熔点: 127ºC
• 分子式: C₁₁H₁₃NO₄
• 分子量: 223.225
• 闪点: 206.3±25.9 °C
• 精确质量: 223.084457
• PSA: 64.63000
• LogP: 1.89
• 蒸汽压: 0.0±1.0 mmHg at 25°C
• 折射率: 1.553
• 储存条件: 室温，干燥

安全

• 符号: GHS07
• 信号词: Warning
• 危害声明: H302-H319
• 警示性声明: P301 + P312 + P330-P305 + P351 + P338
• 危害码 (欧洲): Xn
• 危险品运输编码: NONH for all modes of transport
• 海关编码: 2942000000

合成路线

27492-84-8 108-24-7 ~87% 4093-29-2

文献：Pham, Tien Q.; Greguric, Ivan; Liu, Xiang; Berghofer, Paula; Ballantyne, Patrice; Chapman, Janette; Mattner, Filomena; Dikic, Branko; Jackson, Timothy; Loc'h, Christian; Katsifis, Andrew Journal of Medicinal Chemistry, 2007 , vol. 50, # 15 p. 3561 - 3572

50-86-2 584-08-7 77-78-1 ~89% 4093-29-2

文献：Anphar, S.A. Patent: US4138492 A1, 1979 ;

4093-28-1 74-88-4 ~96% 4093-29-2

文献：MacKenzie, A. Roderick; Moody, Christopher J.; Rees, Charles W. Tetrahedron, 1986 , vol. 42, # 12 p. 3259 - 3268

65-49-6 ~% 4093-29-2

文献：Deng, Xin; Zhao, Xinxin; Han, Jing; Wang, Jingjie; Huang, Wenlong; Qian, Hai; Ge, Liang Letters in Drug Design and Discovery, 2012 , vol. 9, # 5 p. 489 - 493

4136-97-4 ~% 4093-29-2

文献：Deng, Xin; Zhao, Xinxin; Han, Jing; Wang, Jingjie; Huang, Wenlong; Qian, Hai; Ge, Liang Letters in Drug Design and Discovery, 2012 , vol. 9, # 5 p. 489 - 493

50-86-2 77-78-1 ~% 4093-29-2

文献：Barraclough, P.; Beams, R. M.; Black, J. W.; Cambridge, D.; Collard, D.; et al. European Journal of Medicinal Chemistry, 1990 , vol. 25, # 6 p. 467 - 477

4093-28-1 77-78-1 ~% 4093-29-2

文献：Deng, Xin; Zhao, Xinxin; Han, Jing; Wang, Jingjie; Huang, Wenlong; Qian, Hai; Ge, Liang Letters in Drug Design and Discovery, 2012 , vol. 9, # 5 p. 489 - 493

67-56-1 55304-05-7 ~% 4093-29-2

文献：Havaldar, Freddy H.; Sharma, Azad Kumar S. Asian Journal of Chemistry, 2011 , vol. 23, # 3 p. 1314 - 1316

上下游产品

上游产品  10
27492-84-8 108-24-7 50-86-2 584-08-7
77-78-1 4093-28-1 74-88-4 65-49-6
4136-97-4 67-56-1
下游产品  10
364-62-5 35290-97-2 4093-41-8 4093-31-6
4093-34-9 72909-34-3 7206-70-4 3614-38-8
155928-39-5 2486-80-8

制备

【方法一】
用对氨基水杨酸以甲醇在硫酸参与下酯化，生成对氨基水杨酸甲酯，然后以乙酸酐乙酰化，进而以硫酸二甲酯醚化制得该品。

海关

海关编码	2924299090
中文概述	2924299090. 其他环酰胺（包括环氨基甲酸酯）（包括其衍生物以及他们的盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途, 包装
Summary	2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%