2121-12-2

• 常用中文名：石蒜碱内铵盐
• 常用英文名：Lycobetaine(Ungeremine)
• CAS号：2121-12-2
• 分子式：C₁₆H₁₂NO₃
• 分子量：266.27100
• 相关类别： 信号通路 细胞凋亡 胱天蛋白酶
• 发布时间：2018-07-13 14:12:11
• 更新时间：2024-01-02 10:14:10
• Ungeremine,一种从 Pancratium Illyricum 提取的菲啶类生物碱。Ungeremine 有效地靶向哺乳动物以及细菌的 I 型和 II 型拓扑异构酶。Ungeremine 对 9 种癌细胞系表现出细胞毒活性,包括药物敏感性和 MDR 表型。Ungeremine 诱导铁营养症、坏死、自噬以及caspase激活介导的细胞凋亡、MMP 改变和 ROS 生成增加。

名称

• 中文名: 石蒜碱内铵盐
• 英文名: ungeremine
• 中文别名: 恩其明
• 英文别名: Ungerimine

物化性质

• 熔点: 270-272ºC (dec.)
• 分子式: C₁₆H₁₂NO₃
• 分子量: 266.27100
• 精确质量: 266.08200
• PSA: 42.57000
• LogP: 2.27090
• 储存条件: -20°C，密闭，干燥

生物活性

• 描述: Ungeremine,一种从 Pancratium Illyricum 提取的菲啶类生物碱。Ungeremine 有效地靶向哺乳动物以及细菌的 I 型和 II 型拓扑异构酶。Ungeremine 对 9 种癌细胞系表现出细胞毒活性,包括药物敏感性和 MDR 表型。Ungeremine 诱导铁营养症、坏死、自噬以及caspase激活介导的细胞凋亡、MMP 改变和 ROS 生成增加。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 细胞周期/DNA损伤 >> 拓扑异构酶
  信号通路 >> 细胞凋亡 >> Ferroptosis
  信号通路 >> 细胞凋亡 >> 胱天蛋白酶
  信号通路 >> 自噬 >> 自噬
• 参考文献:

  [1]. Casu L, et al. Ungeremine effectively targets mammalian as well as bacterial type I and type II topoisomerases.

  [2]. Mbaveng A, et al. Cytotoxicity of ungeremine towards multi-factorial drug resistant cancer cells and induction of apoptosis, ferroptosis, necroptosis and autophagy. Phytomedicine. 2019 Jul;60:152832.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : OL2827500 CHEMICAL NAME : Lycoranium, 1,2,3,3a,6,7,12b,12c-octadehydro-2-hydroxy- CAS REGISTRY NUMBER : 2121-12-2 LAST UPDATED : 198910 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C16-H12-N-O3 MOLECULAR WEIGHT : 266.29 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 90 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : YHTPAD Yaoxue Tongbao. Bulletin of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.13-23, 1978-88. For publisher information, see ZYZAEU. Volume(issue)/page/year: 23,316,1988 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 72 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : YHTPAD Yaoxue Tongbao. Bulletin of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.13-23, 1978-88. For publisher information, see ZYZAEU. Volume(issue)/page/year: 23,316,1988 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal DOSE : 75 mg/kg SEX/DURATION : male 3 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - testes, epididymis, sperm duct REFERENCE : PLMEAA Planta Medica. (Georg Thieme Verlag, Postfach 732, D-7000 Stuttgart 1, Fed. Rep. Ger.) V.1- 1953- Volume(issue)/page/year: 54,114,1988