80370-57-6

• 常用中文名：头孢噻呋
• 常用英文名：ceftiofur
• CAS号：80370-57-6
• 分子式：C₁₉H₁₇N₅O₇S₃
• 分子量：523.563
• 相关类别： 原料药 抗生素类药物 头孢菌素类药
• 发布时间：2018-05-07 08:00:00
• 更新时间：2026-07-01 23:08:31
• Ceftiofur 是一种半合成抗生素,对针对家畜的各种革兰氏阳性和革兰氏阴性菌、好氧菌和厌氧菌均有抗菌活性。

名称

• 中文名: 头孢噻呋
• 英文名: Ceftiofur
• 中文别名: 头孢噻呋碱/头孢噻呋自由酸; 13C,2H3]-头孢噻呋甲酸盐; 头抱噻呋; 头孢噻呋溶液,100PPM; 3-[(2-呋喃羰基)硫代]甲基]-7-[2-(2-氨基-4-噻唑基)-2-(甲氧基亚氨基乙酰胺基)-3-头孢烯-4-羧酸; 头孢替呋钠; (6R,7R)-7-[2-(2-氨基噻唑-4-基)(甲氧基亚胺基)乙酰胺基]-3-[(2-呋喃基羰基)硫甲基]-8-氧代-5-硫杂-1-氮杂双环[4.2.0]辛-2-烯-2-甲酸; 头孢噻呋 标准品; 头孢噻呋-[13C, D3]/精确称量; 头孢噻呋(盐酸头孢噻呋); 头孢噻呋/头孢噻呋自由酸; 头孢噻呋检测标准品; 乙腈:N,N二甲基甲酰胺 =3:1 (包含 二甲基亚砜)中头孢噻呋; Ceftiofur :头孢噻呋; 甲醇中头孢噻呋溶液标准物质; 氘3-头孢噻呋; 原料头孢噻呋; 头孢噻呋酸; 头孢噻呋溶液
• 英文别名: Excenel, 3-[(2-Furylcbonyl)thio]methyl]-7-[2-(2-amino-4-thiazolyl)-2-(methoxyiminoacetamido)-3-chem-4-cboxylic acid; [6R-[6α,7β(Z)]]-7-[[(2-Amino-4-thiazolyl)(MethoxyiMino)acetyl]amino]-3-[[(2-furanylcbonyl)thio]Methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-cboxylic Acid; naxcel; CEFTIOFUR; Ceftiofur in Acetonitrile:DMF=3:1(DMSO); Ceftiofur-[13C, d3]; ceftiofur acid; EXCENEL; Ceftiofur crystalline free acid; Ceftiofur formate salt; CeftiofurFreeAcid; Ceftiofur Free Acid; Ceftiofur Hydrochloride And SodiuM; (6R-(6alpha,7beta(Z))-7-(((2-Amino-4-thiazolyl)(methoxyimino)acetyl)amino)-3-(((2-furanylcbonyl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-cboxylic acid; (6R,7R)-7-{[(2Z)-2-(2-Amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-[(2-furoylsulfanyl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; 5-Thia-1-azabicyclo4.2.0oct-2-ene-2-cboxylic acid, 7-(2Z)-(2-amino-4-thiazolyl)(methoxyimino)acetylamino-3-(2-furanylcbonyl)thiomethyl-8-oxo-, (6R,7R); Ceftiofur 100 μg/mL in Acetonitrile/Water; C11065000 Ceftiofur; (6R,7R)-7-[2-(2-Amino-4-thiazolyl)glyoxylamido]-3-(mercaptomethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid 72-(Z)-(O-Methyloxime)2-Furoate (Ester); CM 31-916; (6R,7R)-7-[[(2Z)-(2-Amino-4-thiazolyl)(MethoxyiMino)acetyl]amino]-3-[[(2-furany; (6R,7R)-7-((Z)-2-(2-aMinothiazol-4-yl)-2-(MethoxyiMino)acetaMido)-3-(((furan-2-carbonyl)thio)Methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-cboxylic acid; [6R-[6a,7b(Z)]]-7-[[(2-Amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-[[(2-furanylcarbonyl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid; Ceftiofur //BP; U-67279A; Ceftiofur See C244700; Ceftiofur Hcl And Sodium; 13C,2H3]-Ceftiofur formate salt; CEFTIFURHCL; Ceftiofur acid; Cefthiofur; 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-cboxylic acid, 7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-3-[[(2-furanylcbonyl)thio]methyl]-8-oxo-, (6R,7R); Excenel; Ceftiofuran; (6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-{[(furan-2-ylcarbonyl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; Ceftiofur, >=; CeftiofurQ: What is Ceftiofur Q: What is the CAS Number of Ceftiofur Q: What is the storage condition of Ceftiofur Q: What e the applications of Ceftiofur; 3-[(2-FURYLCBONYL)THIO]METHYL]-7-[2-(2-AMINO-4-THIAZOLYL)-2-(METHOXYIMINOACETAMIDO)-3-CHEM-4-CBOXYLIC ACID; CEFTIOFUR HCL; D3-Ceftiofur

物化性质

• 密度: 1.8±0.1 g/cm3
• 分子式: C₁₉H₁₇N₅O₇S₃
• 分子量: 523.563
• 精确质量: 523.028992
• PSA: 256.26000
• LogP: 2.05
• 外观性状: 白色至灰白色粉末
• 折射率: 1.820
• 储存条件: 0-6°C

生物活性

• 描述: Ceftiofur 是一种半合成抗生素,对针对家畜的各种革兰氏阳性和革兰氏阴性菌、好氧菌和厌氧菌均有抗菌活性。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 细菌
• 参考文献:

  [1]. Fernández-Varón E, et al. Pharmacokinetics (PK), pharmacodynamics (PD), and PK-PD integration of ceftiofur after a single intravenous, subcutaneous and subcutaneous-LA administration in lactating goats. BMC Vet Res. 2016 Oct 13;12(1):232.

安全

• 个人防护装备: Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
• 安全声明 (欧洲): 24/25
• 危险品运输编码: NONH for all modes of transport
• 海关编码: 2941905700

合成路线

63527-52-6 4741-45-1 ~52% 80370-57-6

文献：LUPIN LIMITED Patent: US2004/132996 A1, 2004 ; Location in patent: Page 9 ;

4741-45-1 64485-93-4 ~25% 80370-57-6

文献：LUPIN LIMITED Patent: US2004/132996 A1, 2004 ; Location in patent: Page 12 ;

111230-59-2 401837-83-0 17356-08-0 ~% 80370-57-6

文献：WO2008/47376 A1, ; Page/Page column 4; 7; 12-14 ;

上下游产品

上游产品  4
63527-52-6 4741-45-1 64485-93-4 111230-59-2
下游产品  0

海关

海关编码	2941905700