57103-68-1

• 常用中文名：美登醇
• 常用英文名：Maytansinol
• CAS号：57103-68-1
• 分子式：C₂₈H₃₇ClN₂O₈
• 分子量：565.055
• 相关类别： 信号通路 抗体- 药物偶联物 ADC细胞毒素
• 发布时间：2018-03-17 08:00:00
• 更新时间：2026-07-01 01:43:21
• Maytansinol抑制微管组装且诱导微管解, 与辐射联用, 用于果蝇和人类癌细胞。

名称

• 中文名: 美登醇
• 英文名: maytansinol
• 中文别名: 美登醇 安丝菌素 P 0; (14S,16S,32S,33S,2R,4S,10E,12E,14R)-86-氯-14,4-二羟基-85,14-二甲氧基-33,2,7,10-四甲基-7-氮杂-1(6,4)-OXAZINANA-3(2,3)-OXIRANA-8(1,3)-苯环十四烷-10,12-二烯-12,6-二酮; 安沙菌素P0 (美登醇); 安沙菌素P-0; 美登醇/安丝菌素; 美登纯; 安丝菌素P-0(AP0); 安丝菌素 P 0; 美登醇,10 MM DMSO 溶液; Maytansinol试剂; MAYTANSINOL美登醇; 美登醇产品系列; 安丝菌素P-0/美登醇; 美登醇|||ANSAMITOCIN P-0; 安丝菌素 P0
• 英文别名: 11-chloro-6,21-dihydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-4,24-dioxa-9,22-diazatetracyclo[19.3.,14~.,5~]hexacosa-10,11,13,16,18-pentaene-8,23-dione; 11-chloro-6,21-dihydroxy-12,20-dimethoxy-2,5,9,16-tetramethy; Maytansino; Maytansine, O3-de2-(acetylmethylamino)-1-oxopropyl; Ansamitocin P0; (1S,2R,3S,5S,6S,16E,18E,20R,21S)-11-chloro-6,21-dihydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-4,24-dioxa-9,22-diazatetracyclo[19.3.1.11,1.03,]hexacosa-10,11,13,16,18-pentaene-8,23-dione; O3-de-(N-acetyl-N-methyl-L-alanyl)-maytansine; (14S,16S,32S,33S,2R,4S,10E,12E,14R)-86-Chloro-14,4-dihydroxy-85,14-dimethoxy-33,2,7,10-tetramethyl-7-aza-1(6,4)-oxazinana-3(2,3)-oxirana-8(1,3)-benzenacyclotetradecaphane-10,12-diene-12,6-dione; ansaMitocin p 0; Maytansine,3-O-de[2; Maytansinol, >=; (1S,2R,3S,5S,6S,16E,18E,20R,21S)-11-Chloro-6,21-dihydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1.0]hexacosa-10(26),11,13,16,18-pentaene-8,23-dione; Maytansinol (7); 3-O-De[2-[methyl(acetyl)amino]-1-oxopropyl]maytansine; Benzoicacid,5-ethynyl-,methylester; Maytasinol; Ansamitocin P-0（Maytansinol）; Antibiotic C 15003P 0; antibiotic c 15003p; Maytansinol/Maytansine; Maytansinol 57-1; 3-o-de(2-(acetylMethylaMino)-1-oxopropyl)Maytansine; Maytansinol, 10 mM in DMSO; AP0; MAYTANSINOL; ANTIBIOTIC C 15003P; Ansamitocin P-0 top3; MAYTANSINOL; Maytansinoid; Maytansinol(Ansamitocin P-0); (3E,5E,7R,84S)-14-chloro-10t,11c-epoxy-84,12c-dihydroxy-15,7r-dimethoxy-3,9c,11t,15-tetramethyl-(84r'H,86c'H)-15-aza-1(1,3)-benzena-8(4,6)-[1,3]oxazinana-cyclopentadecaphane-3,5-diene-82,14-dione; Maytansine,3-O-de[2-(acetylMethylaMino)-1-oxopropyl]

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 835.8±65.0 °C at 760 mmHg
• 熔点: >153C (dec.)
• 分子式: C₂₈H₃₇ClN₂O₈
• 分子量: 565.055
• 闪点: 459.3±34.3 °C
• 精确质量: 564.223816
• PSA: 130.09000
• LogP: 3.73
• 蒸汽压: 0.0±3.2 mmHg at 25°C
• 折射率: 1.607
• 储存条件: 2-8℃，惰性气体氛围

生物活性

• 描述: Maytansinol抑制微管组装且诱导微管解, 与辐射联用, 用于果蝇和人类癌细胞。
• 相关类别:
  信号通路 >> 抗体- 药物偶联物 >> ADC细胞毒素
  信号通路 >> 细胞周期/DNA损伤 >> 微管/微管蛋白
  信号通路 >> 细胞骨架 >> 微管/微管蛋白
  研究领域 >> 癌症
• 参考文献:

  [1]. Edwards A, et al. Combinatorial effect of maytansinol and radiation in Drosophila and human cancer cells. Dis Model Mech. 2011 Jul;4(4):496-503.

合成路线

38997-10-3 ~% 57103-68-1

文献：Journal of medicinal chemistry, , vol. 21, # 1 p. 31 - 37

75340-67-9 ~% 57103-68-1

文献：Journal of the American Chemical Society, , vol. 102, # 21 p. 6613 - 6615

75349-70-1 ~% 57103-68-1

文献：Journal of the American Chemical Society, , vol. 102, # 21 p. 6613 - 6615

75340-66-8 ~% 57103-68-1

文献：Journal of the American Chemical Society, , vol. 102, # 21 p. 6613 - 6615

75349-69-8 ~% 57103-68-1

文献：Journal of the American Chemical Society, , vol. 102, # 21 p. 6613 - 6615

75349-68-7 ~% 57103-68-1

文献：Journal of the American Chemical Society, , vol. 102, # 21 p. 6613 - 6615

66584-72-3 ~% 57103-68-1

文献：Tetrahedron, , vol. 35, p. 1079 - 1085

75340-68-0 ~% 57103-68-1

文献：Journal of the American Chemical Society, , vol. 102, # 21 p. 6613 - 6615

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