20784-60-5

• 常用中文名：4'-O-甲基补骨脂查尔酮
• 常用英文名：4'-O-Methylbroussochalcone B
• CAS号：20784-60-5
• 分子式：C₂₁H₂₂O₄
• 分子量：338.397
• 相关类别： 天然产物 黄酮类化合物
• 发布时间：2018-12-31 14:25:18
• 更新时间：2026-07-01 21:13:43
• 4'-O-Methylbavachalcone 是从补骨脂中分离得到的查尔酮类,可抑制严重急性呼吸综合征冠状病毒 (SARS-CoV) 木瓜样蛋白酶 (PLpro) 的活性,IC50 值为 10.1 μM。

名称

• 中文名: 4'-O-甲基补骨脂查尔酮
• 英文名: (2E)-1-[2-Hydroxy-4-methoxy-5-(3-methyl-2-buten-1-yl)phenyl]-3-(4 -hydroxyphenyl)-2-propen-1-one
• 中文别名: 4‘-甲氧基补骨脂查尔酮; 4'-O-甲基补骨脂查尔酮B4'-O-Methylbroussochalcone B; 4'-O-甲基补骨脂查耳酮B; 4'-O-甲基布鲁索查尔酮B; 4'-O-甲基补骨脂查耳酮B(4'-O-甲基补骨脂查尔酮); 4'-O-甲基补骨脂查耳酮B标准品; 4'-O-甲基补骨脂查尔酮,10 MM DMSO 溶液; 4’-O-甲基补骨脂查尔酮B4'-O-Methylbroussochalcone B; 4'-O-甲基补骨脂查耳酮B对照品; 甲基补骨脂查尔酮; 4'-O-甲基补骨脂查耳酮B/查尔酮; 4'-O-甲基补骨脂查尔酮B; (E)-1-(2-羟基-4-甲氧基-5-(3-甲基-2-丁烯-1-基)苯基)-3-(4-羟基苯基)丙-2-烯-1-酮
• 英文别名: Methylbroussochalcone4'-O- B; O-Methylbroussochalcone B; 2-Propen-1-one, 1-[2-hydroxy-4-methoxy-5-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-, (2E); batracyclin; 4''-O-Methylbavachalcone; O-Methylbroussochalcone B, 4'; (2E)-1-[2-Hydroxy-4-methoxy-5-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one; bavachalcone; Batracylin; 4'-O-Methyl-bavachalcon; (2E)-1-[2-Hydroxy-4-methoxy-5-(3-methylbut-2-en-1-yl)phenyl]-3-(4-hydroxyphenyl)prop-2-en-1-one; 2',4-Dihydroxy-4'-methoxy-5'-(3-methyl-2-butenyl)chalcone; Guaiacol Impurity 14; 1-[2-Hydroxy-4-methoxy-5-(3-methyl-2-butenyl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one; (E)-1-[2-hydroxy-4-methoxy-5-(3-methylbut-2-enyl)phenyl]-3-(4-hydroxyphenyl)prop-2-en-1-one; 4,2'-dihydroxy-4'-methoxy-5'-prenylchalcone; O-Methylbroussochalcone B, 4’; Daniquidone; (E)-1-(2-Hydroxy-4-methoxy-5-(3-methylbut-2-en-1-yl)phenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one; 4'-O-Methylbavachalcone; 4'-O-Methylbroussochalcone B, （4'-O-Methylbavachalcone）; 4''-O-Methylbavachalcone, 10 mM in DMSO

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 552.1±50.0 °C at 760 mmHg
• 分子式: C₂₁H₂₂O₄
• 分子量: 338.397
• 闪点: 194.9±23.6 °C
• 精确质量: 338.151794
• PSA: 66.76000
• LogP: 5.84
• 外观性状: 黄色粉末
• 蒸汽压: 0.0±1.5 mmHg at 25°C
• 折射率: 1.622
• 储存条件: 2-8℃，干燥，密闭

生物活性

• 描述: 4'-O-Methylbavachalcone 是从补骨脂中分离得到的查尔酮类,可抑制严重急性呼吸综合征冠状病毒 (SARS-CoV) 木瓜样蛋白酶 (PLpro) 的活性,IC50 值为 10.1 μM。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> SARS冠状病毒
• 靶点:

  IC50: 10.1 μM (PLpro)[1]

• 参考文献:

  [1]. 4'-O-Methylbavachalcone, et al. Phenolic phytochemical displaying SARS-CoV papain-like protease inhibition from the seeds of Psoralea corylifolia. J Enzyme Inhib Med Chem. 2014 Feb;29(1):59-63.

安全

• 危害码 (欧洲): Xi

合成路线

128961-13-7 ~82% 20784-60-5

文献：Sugamoto, Kazuhiro; Matsusita, Yoh-Ichi; Matsui, Kana; Kurogi, Chiaki; Matsui, Takanao Tetrahedron, 2011 , vol. 67, # 29 p. 5346 - 5359

28448-83-1 123-08-0 ~% 20784-60-5

文献：TAKARA BIO INC. Patent: EP1623704 A1, 2006 ; Location in patent: Page/Page column 59 ;

1092462-95-7 ~% 20784-60-5

文献：Sugamoto, Kazuhiro; Matsusita, Yoh-Ichi; Matsui, Kana; Kurogi, Chiaki; Matsui, Takanao Tetrahedron, 2011 , vol. 67, # 29 p. 5346 - 5359

552-41-0 ~% 20784-60-5

文献：Sugamoto, Kazuhiro; Matsusita, Yoh-Ichi; Matsui, Kana; Kurogi, Chiaki; Matsui, Takanao Tetrahedron, 2011 , vol. 67, # 29 p. 5346 - 5359

6515-21-5 ~% 20784-60-5

文献：Sugamoto, Kazuhiro; Matsusita, Yoh-Ichi; Matsui, Kana; Kurogi, Chiaki; Matsui, Takanao Tetrahedron, 2011 , vol. 67, # 29 p. 5346 - 5359

128961-25-1 ~% 20784-60-5

文献：Sugamoto, Kazuhiro; Matsusita, Yoh-Ichi; Matsui, Kana; Kurogi, Chiaki; Matsui, Takanao Tetrahedron, 2011 , vol. 67, # 29 p. 5346 - 5359

123-08-0 ~% 20784-60-5

文献：Sugamoto, Kazuhiro; Matsusita, Yoh-Ichi; Matsui, Kana; Kurogi, Chiaki; Matsui, Takanao Tetrahedron, 2011 , vol. 67, # 29 p. 5346 - 5359

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