20784-60-5

20784-60-5 structure

Name: 4'-O-Methylbroussochalcone B
Chemical Name: (2E)-1-[2-Hydroxy-4-methoxy-5-(3-methyl-2-buten-1-yl)phenyl]-3-(4 -hydroxyphenyl)-2-propen-1-one
CAS Number: 20784-60-5
Molecular Formula: C₂₁H₂₂O₄
Molecular Weight: 338.397
Catalog: Natural product Flavonoids
Create Date: 2018-12-31 14:25:18
Modify Date: 2025-08-31 18:50:31
4'-O-Methylbavachalcone is a chalcone isolated from Psoralea corylifolia, inhibits severe acute respiratory syndrome coronavirus (SARS-CoV) papain-like protease (PLpro) activity, with an IC50 of 10.1 μM[1].

Name	(2E)-1-[2-Hydroxy-4-methoxy-5-(3-methyl-2-buten-1-yl)phenyl]-3-(4 -hydroxyphenyl)-2-propen-1-one
Synonyms	batracyclin 4,2'-dihydroxy-4'-methoxy-5'-prenylchalcone 2-Propen-1-one, 1-[2-hydroxy-4-methoxy-5-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-, (2E)- (2E)-1-[2-Hydroxy-4-methoxy-5-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one bavachalcone Batracylin 4'-O-Methyl-bavachalcon Daniquidone (2E)-1-[2-Hydroxy-4-methoxy-5-(3-methylbut-2-en-1-yl)phenyl]-3-(4-hydroxyphenyl)prop-2-en-1-one 4'-O-Methylbroussochalcone B

Description	4'-O-Methylbavachalcone is a chalcone isolated from Psoralea corylifolia, inhibits severe acute respiratory syndrome coronavirus (SARS-CoV) papain-like protease (PLpro) activity, with an IC50 of 10.1 μM[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> SARS-CoV
Target	IC50: 10.1 μM (PLpro)[1]
References	[1]. 4'-O-Methylbavachalcone, et al. Phenolic phytochemical displaying SARS-CoV papain-like protease inhibition from the seeds of Psoralea corylifolia. J Enzyme Inhib Med Chem. 2014 Feb;29(1):59-63.

Hazard Codes	Xi

128961-13-7

~82%

20784-60-5

Literature: Sugamoto, Kazuhiro; Matsusita, Yoh-Ichi; Matsui, Kana; Kurogi, Chiaki; Matsui, Takanao Tetrahedron, 2011 , vol. 67, # 29 p. 5346 - 5359

28448-83-1

123-08-0

20784-60-5

Literature: TAKARA BIO INC. Patent: EP1623704 A1, 2006 ; Location in patent: Page/Page column 59 ;

1092462-95-7

20784-60-5

Literature: Sugamoto, Kazuhiro; Matsusita, Yoh-Ichi; Matsui, Kana; Kurogi, Chiaki; Matsui, Takanao Tetrahedron, 2011 , vol. 67, # 29 p. 5346 - 5359

552-41-0

20784-60-5

Literature: Sugamoto, Kazuhiro; Matsusita, Yoh-Ichi; Matsui, Kana; Kurogi, Chiaki; Matsui, Takanao Tetrahedron, 2011 , vol. 67, # 29 p. 5346 - 5359

6515-21-5

20784-60-5

Literature: Sugamoto, Kazuhiro; Matsusita, Yoh-Ichi; Matsui, Kana; Kurogi, Chiaki; Matsui, Takanao Tetrahedron, 2011 , vol. 67, # 29 p. 5346 - 5359

128961-25-1

20784-60-5

Literature: Sugamoto, Kazuhiro; Matsusita, Yoh-Ichi; Matsui, Kana; Kurogi, Chiaki; Matsui, Takanao Tetrahedron, 2011 , vol. 67, # 29 p. 5346 - 5359

123-08-0

20784-60-5

Literature: Sugamoto, Kazuhiro; Matsusita, Yoh-Ichi; Matsui, Kana; Kurogi, Chiaki; Matsui, Takanao Tetrahedron, 2011 , vol. 67, # 29 p. 5346 - 5359