160096-59-3

• 常用中文名：二甲氧基姜黄素
• 常用英文名：Dimethoxycurcumin
• CAS号：160096-59-3
• 分子式：C₂₃H₂₄O₆
• 分子量：396.43
• 相关类别： 信号通路 免疫及炎症 一氧化氮合酶
• 发布时间：2016-09-02 21:55:49
• 更新时间：2024-01-09 22:47:34
• 二甲氧基姜黄素是姜黄素的衍生物,具有抗炎和抗氧化活性[1][2]。

名称

• 中文名: 二甲氧基姜黄素
• 英文名: Dimethoxycurcumin
• 英文别名: Di-O-methylchlordeoxydecarboxyphomazarin; 4',4''-O,O-dimethylcurcumin; 1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-, (1E,6E)-; (1E,6E)-1,7-Bis(3,4-dimethoxyphenyl)hepta-1,6-diene-3,5-dione; curcumin di-O-methyl ether; di-O-methylcurcumin; 1,7-Bis-(3,4-dimethoxy-phenyl)-hepta-1,6-diene-3,5-dione; (1E,6E)-1,7-Bis(3,4-dimethoxyphenyl)-1,6-heptadiene-3,5-dione; Dimethylcurcumin; Dimethoxycurcumin(DiMC)

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 587.0±50.0 °C at 760 mmHg
• 分子式: C₂₃H₂₄O₆
• 分子量: 396.43
• 闪点: 254.4±30.2 °C
• 精确质量: 396.157288
• PSA: 71.06000
• LogP: 4.11
• 蒸汽压: 0.0±1.6 mmHg at 25°C
• 折射率: 1.585
• 储存条件: 2-8°C，保存于惰性气体中

生物活性

• 描述: 二甲氧基姜黄素是姜黄素的衍生物,具有抗炎和抗氧化活性[1][2]。
• 相关类别:
  信号通路 >> 免疫及炎症 >> 一氧化氮合酶
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Patwardhan RS, et al. Dimethoxycurcumin, a metabolically stable analogue of curcumin, exhibits anti-inflammatory activities in murine and human lymphocytes. Biochem Pharmacol

  [2]. Pae HO, et al. Dimethoxycurcumin, a synthetic curcumin analogue with higher metabolic stability, inhibits NO production, inducible NO synthase expression and NF-kappaB activation in RAW264.7 macrophages activated with LPS. Mol Nutr Food Res. 2008 Sep;52(9):1082-91.

合成路线

15001-27-1 39856-08-1 ~20% 160096-59-3

文献：THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION; LI, Pui-Kai; LI, Chenglong; LIN, Jiayuh; FUCHS, James, R. Patent: WO2010/121007 A1, 2010 ; Location in patent: Page/Page column 6; 17-18 ;

120-14-9 123-54-6 ~37% 160096-59-3

文献：Amolins, Michael W.; Peterson, Laura B.; Blagg, Brian S.J. Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 1 p. 360 - 367

458-37-7 77-78-1 ~70% 160096-59-3

文献：Mishra, Satyendra; Karmodiya, Krishanpal; Surolia, Namita; Surolia, Avadhesha Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 6 p. 2894 - 2902

458-37-7 74-88-4 ~79% 160096-59-3

文献：Changtam, Chatchawan; de Koning, Harry P.; Ibrahim, Hasan; Sajid, M. Sohail; Gould, Matthew K.; Suksamrarn, Apichart European Journal of Medicinal Chemistry, 2010 , vol. 45, # 3 p. 941 - 956

120-14-9 123-54-6 ~7% 93006-00-9 160096-59-3

文献：Konno, Hiroyuki; Endo, Hitoshi; Ise, Satomi; Miyazaki, Keiki; Aoki, Hideo; Sanjoh, Akira; Kobayashi, Kazuya; Hattori, Yasunao; Akaji, Kenichi Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 2 p. 685 - 690

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