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65497-07-6生产厂家

65497-07-6价格

65497-07-6

65497-07-6结构式
65497-07-6结构式
  • 常用中文名:商陆皂苷甲
  • 常用英文名:Esculentoside A
  • CAS号:65497-07-6
  • 分子式:C42H66O16
  • 分子量:826.964
  • 相关类别: 生物化工 天然产物
  • 发布时间:2018-03-23 08:00:00
  • 更新时间:2024-01-01 23:08:22
  • Esculentoside A (EsA),一种从商陆 Phytolacca esculenta 根部分离出来的三萜皂苷。Esculentoside A (EsA) 在具有抗炎活性,对环氧合酶-2 (COX-2) 具有选择性抑制活性。Esculentoside A (EsA) 通过抑制 (NF-ΚB) 和丝裂原活化蛋白激酶 (MAPK) 信号通路抑制 LPS 诱导的急性肺损伤 (ALI) 中的炎症反应。

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中文名 商陆皂苷甲
英文名 Esculentoside A
中文别名 商陆皂甙
商陆皂苷A
英文别名 Esculentoside
4-O-(2,23,28-Trihydroxy-29-methoxy-28,29-dioxoolean-12-en-3-yl)pentopyranosyl hexopyranoside
EsculentosideA
(2β,3β)-3-{[4-O-(β-D-Glucopyranosyl)-β-D-xylopyranosyl]oxy}-2,23-dihydroxy-30-methoxy-30-oxoolean-12-en-29-oic acid
Phytolacaponin E
Hexopyranoside, 4-O-(2,23,28-trihydroxy-29-methoxy-28,29-dioxoolean-12-en-3-yl)pentopyranosyl
Olean-12-ene-29,30-dioic acid, 3-[(4-O-β-D-glucopyranosyl-β-D-xylopyranosyl)oxy]-2,23-dihydroxy-, 30-methyl ester, (2β,3β)-
描述 Esculentoside A (EsA),一种从商陆 Phytolacca esculenta 根部分离出来的三萜皂苷。Esculentoside A (EsA) 在具有抗炎活性,对环氧合酶-2 (COX-2) 具有选择性抑制活性。Esculentoside A (EsA) 通过抑制 (NF-ΚB) 和丝裂原活化蛋白激酶 (MAPK) 信号通路抑制 LPS 诱导的急性肺损伤 (ALI) 中的炎症反应。
相关类别
体外研究 Esculentoside A(0-10μM; 24小时)降低了引物巨噬细胞中TNF浓度的释放[4]。
体内研究 Esculentoside A(EsA)(腹腔注射;20 mg/kg;每天一次;4周)通过调节炎性细胞因子,抑制肾细胞增殖和诱导细胞凋亡在治疗BXSB小鼠中起重要作用[2]。Esculentoside A(EsA)(腹腔注射;5,10和20 mg/kg;每天一次;7天)剂量依赖性地降低LPS攻击后小鼠血清中的TNF,IL-1和IL-6水平[4]。动物模型:BXSB小鼠[2]剂量:20 mg/kg给药:腹腔注射;20 mg/kg;每天一次;4周结果:减轻LN的肾损伤。
参考文献

[1]. Wu F, et al. Synthesis, in vitro inhibitory activity towards COX-2 and haemolytic activity of derivatives of esculentoside A. Bioorg Med Chem Lett. 2007 Dec 1;17(23):6430-3. Epub 2007 Oct 5.

[2]. Ma H, et al. The effect of esculentoside A on lupus nephritis-prone BXSB mice. Arch Med Sci. 2013 Apr 20;9(2):354-60.

[3]. Zhong WT, et al. Protective effect of esculentoside A on lipopolysaccharide-induced acute lung injury in mice. J Surg Res. 2013 Nov;185(1):364-72.

[4]. Ju DW, et al. Esculentoside A inhibits tumor necrosis factor, interleukin-1, and interleukin-6 production induced by lipopolysaccharide in mice. Pharmacology. 1998 Apr;56(4):187-95

密度 1.4±0.1 g/cm3
沸点 935.8±65.0 °C at 760 mmHg
分子式 C42H66O16
分子量 826.964
闪点 275.1±27.8 °C
精确质量 826.435059
PSA 262.36000
LogP 3.01
蒸汽压 0.0±0.6 mmHg at 25°C
折射率 1.620

CHEMICAL IDENTIFICATION

RTECS NUMBER :
RK0177530
CHEMICAL NAME :
Olean-12-ene-28,29-dioic acid, 2,23-dihydroxy-3-((4-O-beta-D-glucopyranosyl-beta-D- xylopyranosyl)oxy)-, 29-methyl ester, (2-beta,3-beta,4-alpha,20-beta)-
CAS REGISTRY NUMBER :
65497-07-6
LAST UPDATED :
198706
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C42-H66-O16
MOLECULAR WEIGHT :
827.08

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
42300 ug/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - respiratory depression Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
SYHJAM Saengyak Hakhoechi. Journal of the Society of Pharmacognosy. (Hanguk Saengyak Hakhoe, c/o Natural Products Institute, Seoul National Univ., 28 Yunkeon-Dong, Chong-ro-ku, Seoul 110, Korea) 1970- Volume(issue)/page/year: 10,73,1979
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1200 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Skin and Appendages - hair Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
SHZAAY Shoyakugaku Zasshi. Journal of Pharmacognosy. (Nippon Shoyaku Gakkai, c/o Nippon Gakkai Jimu Senta, 2-4-16 Yayoi, Bunkyo-ku, Tokyo 113, Japan) V.6- 1952- Volume(issue)/page/year: 33,111,1979
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
486 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Skin and Appendages - hair Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
SHZAAY Shoyakugaku Zasshi. Journal of Pharmacognosy. (Nippon Shoyaku Gakkai, c/o Nippon Gakkai Jimu Senta, 2-4-16 Yayoi, Bunkyo-ku, Tokyo 113, Japan) V.6- 1952- Volume(issue)/page/year: 33,111,1979
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
23600 ug/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - respiratory depression Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
SYHJAM Saengyak Hakhoechi. Journal of the Society of Pharmacognosy. (Hanguk Saengyak Hakhoe, c/o Natural Products Institute, Seoul National Univ., 28 Yunkeon-Dong, Chong-ro-ku, Seoul 110, Korea) 1970- Volume(issue)/page/year: 10,73,1979

安全声明 (欧洲) 24/25