PPNDS

• 常用名: PPNDS
• 英文名: PPNDS
• CAS号: 1021868-77-8
• 分子量: 694.361
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₈H₁₁N₄Na₄O₁₄PS₂
• 熔点: N/A
• 闪点: N/A

PPNDS用途

PPNDS四钠是一种选择性和竞争性的梅普林β抑制剂(IC50:80nM,Ki:8nM),也抑制ADAM10(IC50：1.2μM)。PPNDS四钠也是P2X1受体拮抗剂。PPNDS是草履虫ATP受体的激动剂。PPNDS四钠能有效抑制病毒的聚合酶。PPNDS四钠可用于感染和癌症的研究[1][3][4]。

PPNDS名称

• 英文名: Tetrasodium 3-[(E)-{4-formyl-5-hydroxy-6-methyl-3-[(phosphonatooxy)methyl]-2-pyridinyl}diazenyl]-7-nitro-1,5-naphthalenedisulfonate

PPNDS生物活性

• 描述: PPNDS四钠是一种选择性和竞争性的梅普林β抑制剂(IC50:80nM,Ki:8nM),也抑制ADAM10(IC50：1.2μM)。PPNDS四钠也是P2X1受体拮抗剂。PPNDS是草履虫ATP受体的激动剂。PPNDS四钠能有效抑制病毒的聚合酶。PPNDS四钠可用于感染和癌症的研究[1][3][4]。
• 相关类别:
  研究领域 >> 癌症
  研究领域 >> 感染
  信号通路 >> 代谢酶/蛋白酶 >> MMP
  信号通路 >> 跨膜转运 >> P2X受体
• 靶点实验:

  ADAM10:1.2 μM (IC50)

  p2x1 Receptor

• 体外研究: PPNDS四钠抑制美普林β(IC50:80nM)和美普林α(67μM)[1]。PPNDS四钠(0-10μM,15分钟)以0.88μM的IC50值抑制mNV RdRp(鼠诺如病毒RNA依赖性RNA聚合酶)[2]。PPNDS四钠(0.025-10µM)可有效抑制来自测试的三个杯状病毒科属的六种病毒的聚合酶(IC50范围：0.1-2.3µM)[4]。
• 参考文献:

  [1]. Franck Madoux, et al. Development of high throughput screening assays and pilot screen for inhibitors of metalloproteases meprin α and β. Biopolymers. 2014 Sep;102(5):396-406.

  [2]. Romina Croci, et al. PPNDS inhibits murine Norovirus RNA-dependent RNA-polymerase mimicking two RNA stacking bases. FEBS Lett. 2014 May 2;588(9):1720-5.

  [3]. Christopher R Wood, et al. PPNDS is an agonist, not an antagonist, for the ATP receptor of Paramecium. J Exp Biol. 2003 Feb;206(Pt 3):627-36.

  [4]. Natalie E Netzler, et al. Broad-spectrum non-nucleoside inhibitors for caliciviruses. Antiviral Res. 2017 Oct;146:65-75.

PPNDS物理化学性质

• 分子式: C₁₈H₁₁N₄Na₄O₁₄PS₂
• 分子量: 694.361
• 精确质量: 693.904175
• InChIKey: XHWIRFKQZFSILU-UHFFFAOYSA-J
• SMILES: Cc1nc(N=Nc2cc(S(=O)(=O)[O-])c3cc([N+](=O)[O-])cc(S(=O)(=O)[O-])c3c2)c(COP(=O)([O-])[O-])c(C=O)c1O.[Na+].[Na+].[Na+].[Na+]

PPNDS靶点实验

查看更多实验

实验名称：Inhibition of neurosphere proliferation of mouse neural precursor cells by MTT assay 来源：ChEMBL 靶标：N/A External Id：CHEMBL1266185

实验名称：High-throughput screen for inhibitors of the GIV GBA-motif interaction with Galpha-i ... 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：N/A External Id：HMS1303_AS

实验名称：High-throughput screen for inhibitors of the GIV GBA-motif interaction with Galpha-i ... 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：N/A External Id：HMS1303_FP

实验名称：Small-molecule inhibitors of ST2 (IL1RL1) 来源：20881 靶标：interleukin-1 receptor-like 1 isoform [homo sapiens] External Id：ST2_IL33_Inhibitors_Primary_Screening_77700

实验名称：Rescue cell viability in cybrid cells with a genetic mutation in complex 1 of the mit... 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：N/A External Id：HMS1315

实验名称：qHTS assay for measurement of the activity of small molecule inhibitors on Zika virus... 来源：NCGC 靶标：N/A External Id：ZIK097

实验名称：96-well format Chlamydomonas reinhardtii Algae Gravitaxis Assay to measure the differ... 来源：University of Pittsburgh Molecular Library Screening Center 靶标：N/A External Id：MH081217, Chlamydomonas reinhardtii Gravitaxis Assay to Identify Small Molecule Inhibitors of Cilia.

实验名称：High-throughput screen for inhibitors of the GIV GBA-motif interaction with Galpha-i ... 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School External Id：HMS1303

实验名称：qHTS assay to identify small molecule antagonists of the estrogen related receptor (E... 来源：824 靶标：N/A External Id：ERR513

实验名称：qHTS assay to identify small molecule antagonists of the estrogen related receptor (E... 来源：824 External Id：ERR845

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PPNDS英文别名

• 1,5-Naphthalenedisulfonic acid, 3-[(E)-2-[4-formyl-5-hydroxy-6-methyl-3-[(phosphonooxy)methyl]-2-pyridinyl]diazenyl]-7-nitro-, sodium salt (1:4)
• Tetrasodium 3-[(E)-{4-formyl-5-hydroxy-6-methyl-3-[(phosphonatooxy)methyl]-2-pyridinyl}diazenyl]-7-nitro-1,5-naphthalenedisulfonate