PSB 06126

• 常用名: PSB 06126
• 英文名: PSB 06126
• CAS号: 1052089-16-3
• 分子量: 466.44100
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₄H₁₅N₂NaO₅S
• 熔点: N/A
• 闪点: N/A

PSB 06126用途

PSB-06126是一种选择性三磷酸核苷二磷酸水解酶(NTPDase)抑制剂,大鼠NTPDase 1的Ki值为0.33μM,NTPDase 2的Ki为19.1μM,而NTPDase 3的Ki分别为2.22μM。PSB-06126作用于人NTPDase 3,IC50值为7.76μM,Ki值为4.39μM[1][2]。

PSB 06126名称

• 英文名: sodium 1-amino-4-(1-naphthylamino)-9,10-dioxo-9,10-dihydroanthracene-2-sulfonate

PSB 06126生物活性

• 描述: PSB-06126是一种选择性三磷酸核苷二磷酸水解酶(NTPDase)抑制剂,大鼠NTPDase 1的Ki值为0.33μM,NTPDase 2的Ki为19.1μM,而NTPDase 3的Ki分别为2.22μM。PSB-06126作用于人NTPDase 3,IC50值为7.76μM,Ki值为4.39μM[1][2]。
• 相关类别:
  研究领域 >> 癌症
  研究领域 >> 心血管疾病
  信号通路 >> 代谢酶/蛋白酶 >> 磷酸酶
  研究领域 >> 炎症/免疫
  研究领域 >> 神经疾病
• 靶点实验:

  Ki: 0.33 μM (rat NTPDase 1), 19.1 μM (rat NTPDase 2), 2.22 μM (rat NTPDase 3)，4.39 μM (human NTPDase 3)[1][2].

• 体外研究: PSB 06126(3μM)阻断间充质干细胞(MSCs)中NTPDase3的过度表达,通过激活P2X7和P2Y6受体,导致细胞外ATP水平增加,MSCs成骨分化和矿化[3]。
• 参考文献:

  [1]. Younis Baqi, et al. Ecto-nucleotidase inhibitors: recent developments in drug discovery. Mini Rev Med Chem. 2015;15(1):21-33.

  [2]. Amelie Fiene, et al. Fluorescence polarization immunoassays for monitoring nucleoside triphosphate diphosphohydrolase (NTPDase) activity. Analyst. 2015 Jan 7;140(1):140-8.

  [3]. J B Noronha-Matos, et al. Mesenchymal Stem Cells Ageing: Targeting the "Purinome" to Promote Osteogenic Differentiation and Bone Repair. J Cell Physiol. 2016 Sep;231(9):1852-61.

PSB 06126物理化学性质

• 分子式: C₂₄H₁₅N₂NaO₅S
• 分子量: 466.44100
• 精确质量: 466.06000
• PSA: 137.77000
• LogP: 5.58010
• InChIKey: BLOBABILSRPNHR-UHFFFAOYSA-M
• SMILES: Nc1c(S(=O)(=O)[O-])cc(Nc2cccc3ccccc23)c2c1C(=O)c1ccccc1C2=O.[Na+]

PSB 06126靶点实验

查看更多实验

实验名称：Inhibition of rat ecto-5'-nucleotidase expressed in Sf9 cells by capillary electropho... 来源：ChEMBL 靶标：5'-nucleotidase External Id：CHEMBL1065670

实验名称：Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident pro... 来源：NCGC 靶标：N/A External Id：SERCaMPGLuc-p1-antagonist

实验名称：Inhibition of recombinant Legionella pneumophila 130b His6-tagged NTPDase (41 to 393 ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3829314

实验名称：Rescue cell viability in cybrid cells with a genetic mutation in complex 1 of the mit... 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：N/A External Id：HMS1315

实验名称：Antagonist activity against rat P2X2 receptor expressed in Xenopus laevis oocyte asse... 来源：ChEMBL 靶标：P2X purinoceptor 2 External Id：CHEMBL1680807

实验名称：Displacement of [3H]PSB0413 from human platelet P2Y12 receptor 来源：ChEMBL 靶标：P2Y purinoceptor 12 External Id：CHEMBL995340

实验名称：Inhibition of rat ecto-5'-nucleotidase expressed in Sf9 cells by competitive Lineweav... 来源：ChEMBL 靶标：5'-nucleotidase External Id：CHEMBL1065673

实验名称：Cytotoxicity against human 1321N1 cells at 0.1 uM after 72 hrs to 144 hrs by MTT assa... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL995339

实验名称：Tocris HTS for Inhibitors of Aerobactin Synthetase lucA 来源：23265 External Id：IucA Pilot Assay Tocris Library

实验名称：Inhibition of rat ecto-5'-nucleotidase expressed in Sf9 cells by competitive Michaeli... 来源：ChEMBL 靶标：5'-nucleotidase External Id：CHEMBL1065672

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