枸橼酸莫沙必利

• 常用名: 枸橼酸莫沙必利
• 英文名: Mosapride citrate
• CAS号: 112885-42-4
• 分子量: 614.016
• 密度: N/A
• 沸点: 549.2ºC at 760mmHg
• 分子式: C₂₇H₃₃ClFN₃O₁₀
• 熔点: N/A
• 闪点: 286ºC

枸橼酸莫沙必利用途

Mosapride柠檬酸盐是促胃肠动力化合物,是5HT4激动剂。

枸橼酸莫沙必利名称

• 中文名: 4-氨基-5-氯-2-乙氧基-N-[[4-(4-氟苄基)-2-吗啉基]甲基]苯甲酰胺枸橼酸盐
• 英文名: Mosapride citrate
• 中文别名: 柠檬酸莫沙必利

枸橼酸莫沙必利生物活性

• 描述: Mosapride柠檬酸盐是促胃肠动力化合物,是5HT4激动剂。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体
  信号通路 >> 神经信号通路 >> 5-HT受体
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Tack J, et al. Systematic review: cardiovascular safety profile of 5-HT(4) agonists developed for gastrointestinal disorders. Aliment Pharmacol Ther. 2012 Apr;35(7):745-67.

  [2]. Curran MP, et al. Mosapride in gastrointestinal disorders. Drugs. 2008;68(7):981-91.

  [3]. Odaka T, et al. Serotonin 5- HT4 receptor agonist (mosapride citrate). Nihon Rinsho. 2006 Aug;64(8):1491-4.

枸橼酸莫沙必利物理化学性质

• 沸点: 549.2ºC at 760mmHg
• 分子式: C₂₇H₃₃ClFN₃O₁₀
• 分子量: 614.016
• 闪点: 286ºC
• 精确质量: 613.183838
• PSA: 212.44000
• LogP: 2.93620
• InChIKey: HUZTYZBFZKRPFG-UHFFFAOYSA-N
• SMILES: CCOc1cc(N)c(Cl)cc1C(=O)NCC1CN(Cc2ccc(F)cc2)CCO1.O=C(O)CC(O)(CC(=O)O)C(=O)O
• 蒸汽压: 4.11E-12mmHg at 25°C
• 储存条件: Desiccate at RT

枸橼酸莫沙必利毒性和生态

枸橼酸莫沙必利安全信息

• 危害码 (欧洲): Xi

枸橼酸莫沙必利靶点实验

查看更多实验

实验名称：Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression 来源：NCGC External Id：SNCA-p-activity-luciferase

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu... 来源：824 External Id：CYP273

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify pos... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

实验名称：qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity 来源：NCGC External Id：HERG01

实验名称：qHTS for Inhibitors of TGF-b: Cytotox Counterscreen 来源：NCGC 靶标：N/A External Id：SMAD3201

实验名称：uHTS identification of cystic fibrosis induced NFkb Inhibitors in a fluoresence assay 来源：Burnham Center for Chemical Genomics 靶标：cystic fibrosis transmembrane conductance regulator [Homo sapiens] External Id：SBCCG-A764-CF-PAF-Primary-Assay

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ant... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_ANT_FLUO8_1536_1X%INH PRUN

实验名称：qHTS for Inhibitors of TGF-b 来源：NCGC 靶标：Smad3 [Homo sapiens] External Id：SMAD3101

实验名称：Primary qHTS for inhibitors of NSP2Pro chikungunya virus (CHIKV) 来源：NCGC External Id：APP-Toga-CHIKV-nsp2-p

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枸橼酸莫沙必利英文别名

• 4-Amino-5-chloro-2-ethoxy-N-{[4-(4-fluorobenzyl)morpholin-2-yl]methyl}benzamide 2-hydroxypropane-1,2,3-tricarboxylate (1:1)
• (±)-4-Amino-5-chloro-2-ethoxy-N-((4-(4-fluorobenzyl)-2-morpholinyl)methyl)benzamide Citrate
• 4-amino-5-chloro-2-ethoxy-N-{[4-(4-fluorobenzyl)morpholin-2-yl]methyl}benzamide 2-hydroxypropane-1,2,3-tricarboxylate (salt)
• Benzamide (4-amino-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)methyl]-2-morpholinyl]methyl]
• 4-Amino-5-chloro-2-ethoxy-N-{[4-(4-fluorobenzyl)-2-morpholinyl]methyl}benzamide 2-hydroxy-1,2,3-propanetricarboxylate (1:1)
• Benzamide, 4-amino-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)methyl]-2-morpholinyl]methyl]-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1) (salt)
• UNII:MF497J489P
• 4-amino-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)methyl]morpholin-2-yl]methyl]benzamide,2-hydroxypropane-1,2,3-tricarboxylic acid
• MFCD00874415
• Mosapride Citrate
• Mosapride (citrate)
• Mosapride Impurity 2