(S)-10-Hydroxycamptothecin-d5

• 常用名: (S)-10-Hydroxycamptothecin-d5
• 英文名: (S)-10-Hydroxycamptothecin-d5
• CAS号: 1330277-66-1
• 分子量: 369.38
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₀H₁₁D₅N₂O₅
• 熔点: N/A
• 闪点: N/A

(S)-10-Hydroxycamptothecin-d5用途

(S) -10-羟基喜树碱-d5(10-HCPT-d5)是氘标记的(S)-10-羟基喜树碱。(S) -10-羟基喜树碱(10-HCPT)是一种DNA拓扑异构酶I抑制剂。(S) -10-羟基喜树碱具有显著的凋亡诱导作用。(S) -10-羟基喜树碱有可能用于肝癌、胃癌、结肠癌和白血病研究[1][2][3][4]。

(S)-10-Hydroxycamptothecin-d5名称

• 中文名: (S)-10-羟基喜树碱 d5
• 英文名: (S)-10-Hydroxycamptothecin-d5

(S)-10-Hydroxycamptothecin-d5生物活性

• 描述: (S) -10-羟基喜树碱-d5(10-HCPT-d5)是氘标记的(S)-10-羟基喜树碱。(S) -10-羟基喜树碱(10-HCPT)是一种DNA拓扑异构酶I抑制剂。(S) -10-羟基喜树碱具有显著的凋亡诱导作用。(S) -10-羟基喜树碱有可能用于肝癌、胃癌、结肠癌和白血病研究[1][2][3][4]。
• 相关类别:
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  研究领域 >> 癌症
  信号通路 >> 细胞周期/DNA损伤 >> 拓扑异构酶
• 体外研究: 氢、碳和其他元素的稳定重同位素已被纳入药物分子,主要作为药物开发过程中定量的示踪剂。氘化因其可能影响药物的药代动力学和代谢特征而受到关注[1]。
• 参考文献:

  [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

  [2]. Min Liu, et al. Intracellular delivery of 10-hydroxycamptothecinwith targeted nanostructured lipid carriers againstmultidrug resistance. Journal of Drug Targeting.

  [3]. Min Liu, et al. Intracellular delivery of 10-hydroxycamptothecin with targetednanostructured lipid carriers against multidrug resistance. J Drug Target, Early Online: 1–8

  [4]. Yu P, et al. Synthesis and preliminary anticancer evaluation of 10-hydroxycamptothecin analogs. Biol Pharm Bull. 2012;35(8):1295-9.

  [5]. Zhang XW, et al. Differentiation-inducing action of 10-hydroxycamptothecin on human hepatoma Hep G2 cells. Acta Pharmacol Sin. 2000 Apr;21(4):364-8.

  [6]. Zhang XW, et al. Differential regulation of P53, c-Myc, Bcl-2, Bax and AFP protein expression, and caspase activity during 10-hydroxycamptothecin-induced apoptosis in Hep G2 cells. Anticancer Drugs. 2000 Oct;11(9):747-56.

  [7]. Liu M, et al. Intracellular delivery of 10-hydroxycamptothecin with targeted nanostructured lipid carriers against multidrug resistance. J Drug Target. 2016;24(5):433-40.

(S)-10-Hydroxycamptothecin-d5物理化学性质

• 分子式: C₂₀H₁₁D₅N₂O₅
• 分子量: 369.38
• 储存条件: -20°C，干燥，密封