Linagliptin-13C,d3

• 常用名: Linagliptin-13C,d3
• 英文名: Linagliptin-13C,d3
• CAS号: 1398044-43-3
• 分子量: 476.55
• 密度: 1.4±0.1 g/cm3
• 沸点: N/A
• 分子式: C₂₄₁₃CH₂₅D₃N₈O₂
• 熔点: N/A
• 闪点: N/A

Linagliptin-13C,d3用途

利格列汀-13C,d3是13C和氘标记的。利格列汀是一种高效、选择性DPP-4抑制剂,IC50为1 nM。

Linagliptin-13C,d3名称

• 英文名: 8-[(3R)-3-Amino-1-piperidinyl]-7-[(4-13C,4,4,4-2H3)-2-butyn-1-yl]-3-methyl-1-[(4-methyl-2-quinazolinyl)methyl]-3,7-dihydro-1H-purine-2,6-dione

Linagliptin-13C,d3生物活性

• 描述: 利格列汀-13C,d3是13C和氘标记的。利格列汀是一种高效、选择性DPP-4抑制剂,IC50为1 nM。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> 二肽基肽酶
  信号通路 >> 细胞凋亡 >> Ferroptosis
  信号通路 >> 自噬 >> 自噬
  研究领域 >> 代谢疾病
• 体外研究: 氢、碳和其他元素的稳定重同位素已被纳入药物分子中,主要作为药物开发过程中定量的示踪剂。氘化因其可能影响药物的药代动力学和代谢特征而备受关注[82]。
• 参考文献:

  [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223.

  [2]. Eckhardt M, et al. 8-(3-(R)-aminopiperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydropurine-2,6-dione (BI 1356), a highly potent, selective, long-acting, and orally bioavailable DPP-4 inhibitor for the treatment of type 2 d

  [3]. Thomas L, et al. (R)-8-(3-amino-piperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione (BI 1356), a novel xanthine-based dipeptidyl peptidase 4 inhibitor, has a superior potency and longer duration of action

  [4]. Schurmann C, et al. The dipeptidyl peptidase-4 inhibitor linagliptin attenuates inflammation and accelerates epithelialization in wounds of diabetic ob/ob mice. J Pharmacol Exp Ther. 2012 Jul;342(1):71-80.

  [5]. Huan Y, et al. The dual DPP4 inhibitor and GPR119 agonist HBK001 regulates glycemic control and beta cell function ex and in vivo. Sci Rep. 2017 Jun 28;7(1):4351.

Linagliptin-13C,d3物理化学性质

• 密度: 1.4±0.1 g/cm3
• 分子式: C₂₄₁₃CH₂₅D₃N₈O₂
• 分子量: 476.55
• 精确质量: 476.255707
• 折射率: 1.717

Linagliptin-13C,d3英文别名

• 8-[(3R)-3-Amino-1-piperidinyl]-7-[(4-13C,4,4,4-2H3)-2-butyn-1-yl]-3-methyl-1-[(4-methyl-2-quinazolinyl)methyl]-3,7-dihydro-1H-purine-2,6-dione
• 1H-Purine-2,6-dione, 8-[(3R)-3-amino-1-piperidinyl]-7-(2-butyn-1-yl-4-13C-4,4,4-d3)-3,7-dihydro-3-methyl-1-[(4-methyl-2-quinazolinyl)methyl]-
• MFCD30179557