Dexpramipexole-d3 dihydrochloride

• 常用名: Dexpramipexole-d3 dihydrochloride
• 英文名: Dexpramipexole-d3 dihydrochloride
• CAS号: 1432230-09-5
• 分子量: 287.27
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₀H₁₆D₃Cl₂N₃S
• 熔点: N/A
• 闪点: N/A

Dexpramipexole-d3 dihydrochloride用途

盐酸右普拉克索-d3((R)-普拉克索-d3)是氘标记的右普拉克索。右普拉克索((R)-普拉克索),也称为R-(+)-普拉克索,是一种神经保护剂和弱非麦角林多巴胺激动剂[1][2]。

Dexpramipexole-d3 dihydrochloride名称

• 英文名: Dexpramipexole-d3 dihydrochloride

Dexpramipexole-d3 dihydrochloride生物活性

• 描述: 盐酸右普拉克索-d3((R)-普拉克索-d3)是氘标记的右普拉克索。右普拉克索((R)-普拉克索),也称为R-(+)-普拉克索,是一种神经保护剂和弱非麦角林多巴胺激动剂[1][2]。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 多巴胺受体
  信号通路 >> 神经信号通路 >> 多巴胺受体
  研究领域 >> 神经疾病
• 体外研究: 氢、碳和其他元素的稳定重同位素已被纳入药物分子,主要作为药物开发过程中定量的示踪剂。氘化因其可能影响药物的药代动力学和代谢特征而受到关注[1]。
• 参考文献:

  [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

  [2]. Rudnicki SA, Berry JD, Ingersoll E, et al. Dexpramipexole effects on functional decline and survival in subjects with amyotrophic lateral sclerosis in a Phase II study: subgroup analysis of demographic and clinical characteristics. Amyotroph Lateral Scler

  [3]. Alavian KN, Dworetzky SI, Bonanni L, et al. Effects of dexpramipexole on brain mitochondrial conductances and cellular bioenergetic efficiency. Brain Res. 2012 Mar 29;1446:1-11.

  [4]. Cudkowicz M, Bozik ME, Ingersoll EW, et al. The effects of dexpramipexole (KNS-760704) in individuals with amyotrophic lateral sclerosis. Nat Med. 2011 Nov 20;17(12):1652-6.

  [5]. Bozik ME, Mather JL, Kramer WG, et al. Safety, tolerability, and pharmacokinetics of KNS-760704 (dexpramipexole) in healthy adult subjects. J Clin Pharmacol. 2011 Aug;51(8):1177-85.

  [6]. Cheah BC, Kiernan MC. Dexpramipexole, the R(+) enantiomer of pramipexole, for the potential treatment of amyotrophic lateral sclerosis. IDrugs. 2010 Dec;13(12):911-20.

Dexpramipexole-d3 dihydrochloride物理化学性质

• 分子式: C₁₀H₁₆D₃Cl₂N₃S
• 分子量: 287.27