Auristatin E.

• 常用名: Auristatin E.
• 英文名: Auristatin E
• CAS号: 160800-57-7
• 分子量: 732.005
• 密度: 1.1±0.1 g/cm3
• 沸点: 871.0±65.0 °C at 760 mmHg
• 分子式: C₄₀H₆₉N₅O₇
• 熔点: N/A
• 闪点: 480.6±34.3 °C

Auristatin E.用途

Auristatin E是细胞毒性分子,微管蛋白修饰分子,强效抗肿瘤活性,MMAE的类似物以及在抗体药物偶连体开发中作为毒素分子。

Auristatin E.名称

• 中文名: Auristatin E.
• 英文名: N,N-Dimethyl-L-valyl-N-[(3R,4S,5S)-1-{(2S)-2-[(1R,2R)-3-{[(1S,2R)-1-hydroxy-1-phenyl-2-propanyl]amino}-1-methoxy-2-methyl-3-oxopropyl]-1-pyrrolidinyl}-3-methoxy-5-methyl-1-oxo-4-heptanyl]-N-methyl-L-valinamide

Auristatin E.生物活性

• 描述: Auristatin E是细胞毒性分子,微管蛋白修饰分子,强效抗肿瘤活性,MMAE的类似物以及在抗体药物偶连体开发中作为毒素分子。
• 相关类别:
  信号通路 >> 抗体- 药物偶联物 >> ADC细胞毒素
  信号通路 >> 细胞周期/DNA损伤 >> 微管/微管蛋白
  信号通路 >> 细胞骨架 >> 微管/微管蛋白
  研究领域 >> 癌症
• 参考文献:

  [1]. Francisco JA, et al. cAC10-vcMMAE, an anti-CD30-monomethyl auristatin E conjugate with potent and selective antitumor activity. Blood. 2003 Aug 15;102(4):1458-65.

  [2]. Li D, et al. DCDT2980S, an anti-CD22-monomethyl auristatin E antibody-drug conjugate, is a potential treatment for non-Hodgkin lymphoma. Mol Cancer Ther. 2013 Jul;12(7):1255-65.

Auristatin E.物理化学性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 871.0±65.0 °C at 760 mmHg
• 分子式: C₄₀H₆₉N₅O₇
• 分子量: 732.005
• 闪点: 480.6±34.3 °C
• 精确质量: 731.519714
• LogP: 4.75
• InChIKey: WOWDZACBATWTAU-FEFUEGSOSA-N
• SMILES: CCC(C)C(C(CC(=O)N1CCCC1C(OC)C(C)C(=O)NC(C)C(O)c1ccccc1)OC)N(C)C(=O)C(NC(=O)C(C(C)C)N(C)C)C(C)C
• 蒸汽压: 0.0±0.3 mmHg at 25°C
• 折射率: 1.519
• 储存条件: 2-8℃

Auristatin E.靶点实验

查看更多实验

实验名称：Growth inhibition of human NCI-H460 cells after 48 hrs by SRB assay 来源：ChEMBL 靶标：NCI-H460 External Id：CHEMBL4133672

实验名称：Growth inhibition of human KM20L2 cells after 48 hrs by SRB assay 来源：ChEMBL 靶标：KM-20L2 External Id：CHEMBL4133673

实验名称：Growth inhibition of human MCF7 cells after 48 hrs by SRB assay 来源：ChEMBL 靶标：MCF7 External Id：CHEMBL4133670

实验名称：Growth inhibition of human SF268 cells after 48 hrs by SRB assay 来源：ChEMBL 靶标：SF-268 External Id：CHEMBL4133671

实验名称：Growth inhibition of human BxPC3 cells after 48 hrs by SRB assay 来源：ChEMBL 靶标：BXPC-3 External Id：CHEMBL4133669

实验名称：Growth inhibition of human DU145 cells after 48 hrs by SRB assay 来源：ChEMBL 靶标：DU-145 External Id：CHEMBL4133674

实验名称：Antitumor activity against human HCT-116 cells xenografted in BALB/C mouse assessed a... 来源：ChEMBL 靶标：HCT-116 External Id：CHEMBL5370439

实验名称：Toxicity in BALB/c mouse assessed as side effect at 2 to 4 mg/kg, iv administered eve... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5370438

实验名称：Antiproliferative activity against human A549 cells assessed as inhibition of cell gr... 来源：ChEMBL 靶标：A549 External Id：CHEMBL5370431

实验名称：Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell... 来源：ChEMBL 靶标：HCT-116 External Id：CHEMBL5370432

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Auristatin E.英文别名

• N,N-Dimethyl-L-valyl-N-[(3R,4S,5S)-1-{(2S)-2-[(1R,2R)-3-{[(1S,2R)-1-hydroxy-1-phenyl-2-propanyl]amino}-1-methoxy-2-methyl-3-oxopropyl]-1-pyrrolidinyl}-3-methoxy-5-methyl-1-oxo-4-heptanyl]-N-methyl-L-valinamide
• MFCD25976744
• Auristatin E