喷布洛尔

• 常用名: 喷布洛尔
• 英文名: Penbutolol
• CAS号: 38363-40-5
• 分子量: 291.42800
• 密度: 1.03g/cm3
• 沸点: 438.2ºC at 760mmHg
• 分子式: C₁₈H₂₉NO₂
• 熔点: N/A
• 闪点: 218.8ºC

喷布洛尔用途

(-)-戊丁洛尔((S)-戊丁洛醇)是一种有效的β-肾上腺素受体和5-HT受体拮抗剂,在大鼠氨角1(CA1)和人CA3中,5-HT的Ki值分别为11.6nM和11.9nM。(-)戊丁洛l可增加海马5-HT输出[1][2]。

喷布洛尔名称

• 中文名: 喷布洛尔
• 英文名: Penbutolol intermediates

喷布洛尔生物活性

• 描述: (-)-戊丁洛尔((S)-戊丁洛醇)是一种有效的β-肾上腺素受体和5-HT受体拮抗剂,在大鼠氨角1(CA1)和人CA3中,5-HT的Ki值分别为11.6nM和11.9nM。(-)戊丁洛l可增加海马5-HT输出[1][2]。
• 相关类别:
  研究领域 >> 内分泌
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 肾上腺素能受体
  研究领域 >> 神经疾病
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体
  信号通路 >> 神经信号通路 >> 5-HT受体
• 靶点实验:

  β-adrenoceptor, 5-HT receptor[1][2]

• 参考文献:

  [1]. Hjorth S, et al. In vivo microdialysis evidence for central serotonin1A and serotonin1B autoreceptor blocking properties of the beta adrenoceptor antagonist (-)penbutolol. J Pharmacol Exp Ther. 1993 May;265(2):707-12.

  [2]. M E Castro, et al. Affinity of (±)-Pindolol, (-)-Penbutolol, and (-)-Tertatolol for Pre- and Postsynaptic Serotonin 5-HT1A Receptors in Human and Rat Brain. Journal of Neurochemistry, Volume 75, Issue 2, p. 755-762.

喷布洛尔物理化学性质

• 密度: 1.03g/cm3
• 沸点: 438.2ºC at 760mmHg
• 分子式: C₁₈H₂₉NO₂
• 分子量: 291.42800
• 闪点: 218.8ºC
• 精确质量: 291.22000
• PSA: 41.49000
• LogP: 3.86290
• InChIKey: KQXKVJAGOJTNJS-HNNXBMFYSA-N
• SMILES: CC(C)(C)NCC(O)COc1ccccc1C1CCCC1
• 折射率: 1.527

喷布洛尔毒性和生态

喷布洛尔靶点实验

查看更多实验

实验名称：Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effec... 来源：ChEMBL 靶标：Hepatotoxicity External Id：CHEMBL1909317

实验名称：Binding affinity towards human GABRA1 in an in vitro assay with cellular components m... 来源：ChEMBL 靶标：Gamma-aminobutyric acid receptor subunit gamma-2 External Id：CHEMBL5291799

实验名称：Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effec... 来源：ChEMBL 靶标：Hepatotoxicity External Id：CHEMBL1909316

实验名称：Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effec... 来源：ChEMBL 靶标：Hepatotoxicity External Id：CHEMBL1909319

实验名称：The drug is tested on Z-003 corresponding to pig gut metagenome with ENA study access... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5724941

实验名称：Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effec... 来源：ChEMBL 靶标：Hepatotoxicity External Id：CHEMBL1909318

实验名称：Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effec... 来源：ChEMBL 靶标：Hepatotoxicity External Id：CHEMBL1909320

实验名称：The drug is tested on WLS-427 corresponding to human gut metagenome with ENA study ac... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5724944

实验名称：Binding affinity towards human ESR1 in an in vitro cell free assay (CRO assay) measur... 来源：ChEMBL 靶标：Estrogen receptor External Id：CHEMBL5291792

实验名称：Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effec... 来源：ChEMBL 靶标：Hepatotoxicity External Id：CHEMBL1909309

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