新霉胺
新霉胺结构式
|
常用名 | 新霉胺 | 英文名 | neamine |
|---|---|---|---|---|
| CAS号 | 3947-65-7 | 分子量 | 322.358 | |
| 密度 | 1.5±0.1 g/cm3 | 沸点 | 577.9±50.0 °C at 760 mmHg | |
| 分子式 | C12H26N4O6 | 熔点 | 225.5°C (rough estimate) | |
| MSDS | N/A | 闪点 | 303.3±30.1 °C |
新霉胺用途Neamine 是一种 Neomycin 的无毒衍生物,也是一种广谱氨基糖苷类抗生素。Neamine 是靶向血管生成素 (angiogenin) 的抗血管生成剂。Neamine 具有有效的抗菌,抗肿瘤和神经保护活性。 |
| 中文名 | 新霉胺 |
|---|---|
| 英文名 | neamine |
| 中文别名 | 工厂已不再生产 | 新黴素A |
| 英文别名 | 更多 |
| 描述 | Neamine 是一种 Neomycin 的无毒衍生物,也是一种广谱氨基糖苷类抗生素。Neamine 是靶向血管生成素 (angiogenin) 的抗血管生成剂。Neamine 具有有效的抗菌,抗肿瘤和神经保护活性。 |
|---|---|
| 相关类别 | |
| 体外研究 | Neamine(0.625-25μM；48小时；AsPC-1细胞)在0.625-25μM范围内以剂量依赖的方式抑制ANG介导的AsPC-1细胞增殖[1]。Neamine(100μM)也能有效地阻断ANG的核转位[1]。细胞增殖试验[1]细胞系：AsPC-1细胞浓度：0.625µM、1.25µM、2.5µM、5µM、10µM、25µM孵育时间：48小时结果：抑制血管生长素(ANG)诱导的AsPC-1细胞增殖。 |
| 体内研究 | Neamine(30-60mg/kg；皮下注射；每日；连续14天；雄性Balb/c裸鼠)对AsPC-1异种移植模型具有抗肿瘤作用。Neamine降低肿瘤移植瘤血管紧张素、Ki-67和CD31的表达水平[1]。动物模型：雄性Balb/c裸鼠(4周龄)注射AsPC-1细胞[1]剂量：30mg/kg,60mg/kg给药：皮下注射；每日一次；共14d结果：对AsPC-1异种移植模型有抗肿瘤作用。 |
| 参考文献 |
| 密度 | 1.5±0.1 g/cm3 |
|---|---|
| 沸点 | 577.9±50.0 °C at 760 mmHg |
| 熔点 | 225.5°C (rough estimate) |
| 分子式 | C12H26N4O6 |
| 分子量 | 322.358 |
| 闪点 | 303.3±30.1 °C |
| 精确质量 | 322.185242 |
| PSA | 203.46000 |
| LogP | -2.78 |
| 外观性状 | 米白色至浅黄色固体 |
| 蒸汽压 | 0.0±3.6 mmHg at 25°C |
| 折射率 | 1.649 |
| 储存条件 | 2-8°C，惰性气体 |
| 危害码 (欧洲) | T |
|---|
|
CuAAC-mediated diversification of aminoglycoside-arginine conjugate mimics by non-reducing di- and trisaccharides.
Carbohydr. Res. 371 , 61-7, (2013) Di- and triguanidinylation of trehalose, sucrose, and melizitose has been achieved via a Huisgen-cycloaddition approach. They can serve as aminoglycoside-arginine conjugate mimics, which has been demo... |
|
|
Kaposi's sarcoma-associated herpesvirus-positive primary effusion lymphoma tumor formation in NOD/SCID mice is inhibited by neomycin and neamine blocking angiogenin's nuclear translocation.
J. Virol. 87(21) , 11806-20, (2013) Angiogenin (ANG) is a 14-kDa multifunctional proangiogenic secreted protein whose expression level correlates with the aggressiveness of several tumors. We observed increased ANG expression and secret... |
|
|
Investigation of RNA-ligand interactions by 19F NMR spectroscopy using fluorinated probes.
Angew. Chem. Int. Ed. Engl. 51(38) , 9530-4, (2012)
|
| (1R,2R,3S,4R,6S)-4,6-Diamino-2,3-dihydroxycyclohexyl 2,6-diamino-2,6-dideoxy-α-D-glucopyranoside |
| 2-Deoxy-4-O-(2,6-diamine-2,6-dideoxy-α-D-glucopyranosyl)-D-streptamine |
| U-5214 |
| α-D-Glucopyranoside, (1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl 2,6-diamino-2,6-dideoxy- |
| Neomycin A |
| Negamicin |
| dekamycinv |
| Neamine |
| neomycina |
| (2R,3S,4R,5R,6R)-6-((1R,2R,3S,4R,6S)-4,6-DIAMINO-2,3-DIHYDROXYCYCLOHEXYLOXY)-5-AMINO-2-(AMINOMETHYL)-TETRAHYDRO-2H-PYRAN-3,4-DIOL |
| 2-Deoxy-4-O-(2,6-diamino-2,6-dideoxy-a-D-glucopyranosyl)-D-streptamine |
| neamin |
| (1'R,3'S,3S,5R,6R)-5-AMINO-2-AMINOMETHYL-6-(4,6-DIAMINO-2,3-DIHYDROXY-CYCLOHEXYLOXY)-TETRAHYDRO-PYRAN-3,4-DIOL |
| nebramycinx |
