3947-65-7

• 常用中文名：新霉胺
• 常用英文名：neamine
• CAS号：3947-65-7
• 分子式：C₁₂H₂₆N₄O₆
• 分子量：322.358
• 相关类别： 分析化学 标准品 药典标准品和杂志标准品
• 发布时间：2018-06-05 08:00:00
• 更新时间：2026-07-11 15:31:49
• Neamine 是一种 Neomycin 的无毒衍生物,也是一种广谱氨基糖苷类抗生素。Neamine 是靶向血管生成素 (angiogenin) 的抗血管生成剂。Neamine 具有有效的抗菌,抗肿瘤和神经保护活性。

名称

• 中文名: 新霉胺
• 英文名: neamine
• 中文别名: 妥布霉素杂质3; 硫酸新霉素杂质 A; 硫酸新霉素杂质1(硫酸新霉素杂质A); 硫酸弗雷米锡杂质A; 妥布霉素杂质3 (妥布霉素杂质 C )(新霉胺); 硫酸新霉素杂质A(新霉胺); 新霉素杂质A; 硫酸新霉素杂质A(NEAMINE); 新霉素 标准品; (3S,5R,6R)-5-氨基-2-(氨基甲基)-6-(((1R,3S)-4,6-二氨基-2,3-二羟基环己基)氧基)四氢-2H-吡喃-3,4-二醇; 工厂已不再; 硫酸新霉素杂质A(妥布霉素杂质C)(新霉胺对照品); 新黴素A; 硫酸新霉素杂质A; (2R,3S,4R,5R,6R)-5-氨基-2-(氨基甲基)-6-(((1R,2R,3S,4R,6S)-4,6-二氨基-2,3-二羟基环己基)氧基)四氢-2H-吡喃-3,4-二醇; 工厂已不再生产
• 英文别名: (2R,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-(((1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl)oxy)tetrahydro-2H-pyran-3,4-diol; (1R,3S,3S,5R,6R)-5-AMINO-2-AMINOMETHYL-6-(4,6-DIAMINO-2,3-DIHYDROXY-CYCLOHEXYLOXY)-TETRAHYDRO-PYRAN-3,4-DIOL; Framycetin Impurity A; 5-AMINO-2-AMINOMETHYL-6-(4,6-DIAMINO-2,3-DIHYDROXY-CYCLOHEXYLOXY)-TETRAHYDRO-PYRAN-3,4-DIOL; (1R,2R,3S,4R,6S)-4,6-Diamino-2,3-dihydroxycyclohexyl 2,6-diamino-2,6-dideoxy-α-D-glucopyranoside; D-Strtamine, 2-deoxy-4-O-(2,6-diamino-2,6-dideoxy-α-D-glucopyranosyl); 2-deoxy-4-O-(2,6-diamino-2,6-dideoxy-α-D-glucopyranosyl)-D-strtamine (neamine or neomycin A-LP); Neomycin A Sulfate (Neamine), EvoPure; Neomycin Sulfate Impurity A（Tobramycin Impurity C）; Neomycin A sulfate (Neamine); Neomycin Sulfate Impurity A (Neamine)Q: What is Neomycin Sulfate Impurity A (Neamine) Q: What is the CAS Number of Neomycin Sulfate Impurity A (Neamine) Q: What is the storage condition of Neomycin Sulfate Impurity A (Neamine) Q: What e the applications of Neomycin Sulfate Impurity A (Neamine); Tobramycin Impurity 3 (Tobramycin Impurity C) (Neamine); Negamicin; dekamycinv; Neamine (synonym: Neomycin Sulfate Impurity A); 2-deoxy-4-o-(2,6-diamino-2,6-dideoxy-alpha-d-glucopyranosyl)-d-strtamin; Neamine CRS; Neamine (N0300000)Q: What is Neamine (N0300000) Q: What is the CAS Number of Neamine (N0300000) Q: What e the applications of Neamine (N0300000); (2R,3S,4R,5R,6R)-6-((1R,2R,3S,4R,6S)-4,6-DIAMINO-2,3-DIHYDROXYCYCLOHEXYLOXY)-5-AMINO-2-(AMINOMETHYL)-TETRAHYDRO-2H-PYRAN-3,4-DIOL; Framycetin sulfate Impurity A; nebramycinx; NEAMINE; 2-Deoxy-4-O-(2,6-diamine-2,6-dideoxy-α-D-glucopyranosyl)-D-streptamine; Neomycin Sulfate Impurity A (Neamine); 5-amino-2-(aminomethyl)-6-(4,6-diamino-2,3-dihydroxycyclohexyl)oxyoxane-3,4-diol; U-5214; 2-deoxy-4-O-(2,6-diamino-2,6-dideoxy-α-D-glucopyranosyl)-D-strtamine (neamine); Framycetin Impurity 1 (Framycetin Impurity A); Neomycin A; Neomycin sulfate impurity A; 2-Deoxy-4-O-(2,6-diamino-2,6-dideoxy-α-D-glucopyranosyl)-D-strtamine; Neomycin Sulfate Impurity 1（Neomycin Sulfate Impurity A）; Neamine; neomycina; 2-Deoxy-4-O-(2,6-diamino-2,6-dideoxy-a-D-glucopyranosyl)-D-streptamine; neamin; (1'R,3'S,3S,5R,6R)-5-AMINO-2-AMINOMETHYL-6-(4,6-DIAMINO-2,3-DIHYDROXY-CYCLOHEXYLOXY)-TETRAHYDRO-PYRAN-3,4-DIOL; C01441

物化性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 577.9±50.0 °C at 760 mmHg
• 熔点: 225.5°C (rough estimate)
• 分子式: C₁₂H₂₆N₄O₆
• 分子量: 322.358
• 闪点: 303.3±30.1 °C
• 精确质量: 322.185242
• PSA: 203.46000
• LogP: -2.78
• 外观性状: 米白色至浅黄色固体
• 蒸汽压: 0.0±3.6 mmHg at 25°C
• 折射率: 1.649
• 储存条件: 2-8°C，惰性气体

生物活性

• 描述: Neamine 是一种 Neomycin 的无毒衍生物,也是一种广谱氨基糖苷类抗生素。Neamine 是靶向血管生成素 (angiogenin) 的抗血管生成剂。Neamine 具有有效的抗菌,抗肿瘤和神经保护活性。
• 相关类别:
  研究领域 >> 癌症
  研究领域 >> 心血管疾病
  研究领域 >> 感染
  研究领域 >> 神经疾病
  信号通路 >> 抗感染 >> 细菌
• 体外研究: Neamine(0.625-25μM；48小时；AsPC-1细胞)在0.625-25μM范围内以剂量依赖的方式抑制ANG介导的AsPC-1细胞增殖[1]。Neamine(100μM)也能有效地阻断ANG的核转位[1]。细胞增殖试验[1]细胞系：AsPC-1细胞浓度：0.625µM、1.25µM、2.5µM、5µM、10µM、25µM孵育时间：48小时结果：抑制血管生长素(ANG)诱导的AsPC-1细胞增殖。
• 体内研究: Neamine(30-60mg/kg；皮下注射；每日；连续14天；雄性Balb/c裸鼠)对AsPC-1异种移植模型具有抗肿瘤作用。Neamine降低肿瘤移植瘤血管紧张素、Ki-67和CD31的表达水平[1]。动物模型：雄性Balb/c裸鼠(4周龄)注射AsPC-1细胞[1]剂量：30mg/kg,60mg/kg给药：皮下注射；每日一次；共14d结果：对AsPC-1异种移植模型有抗肿瘤作用。
• 参考文献:

  [1]. Ya-Ping Liu, et al. Neamine Inhibits Growth of Pancreatic Cancer Cells in Vitro and in Vivo. J Huazhong Univ Sci Technolog Med Sci. 2016 Feb;36(1):82-87.

  [2]. R Ning, et al. Neamine Induces Neuroprotection After Acute Ischemic Stroke in Type One Diabetic Rats. Neuroscience. 2014 Jan 17;257:76-85.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : QP3860000 CHEMICAL NAME : Neomycin A CAS REGISTRY NUMBER : 3947-65-7 BEILSTEIN REFERENCE NO. : 0026714 LAST UPDATED : 199712 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C12-H26-N4-O6 MOLECULAR WEIGHT : 322.42 WISWESSER LINE NOTATION : T6OTJ B1Z CQ DQ EZ FO- BL6TJ AZ CQ DQ EZ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1250 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85ERAY "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978 Volume(issue)/page/year: 1,664,1978 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 125 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 27,677,1974

安全

• 危害码 (欧洲): T