钩藤碱E

• 常用名: 钩藤碱E
• 英文名: Isopteropodine
• CAS号: 5171-37-9
• 分子量: 368.42600
• 密度: 1.33g/cm3
• 沸点: 555.2ºC at 760 mmHg
• 分子式: C₂₁H₂₄N₂O₄
• 熔点: 209-211 °C
• 闪点: 289.6ºC
• 符号: GHS06
• 信号词: Danger

钩藤碱E用途

Isopteropodine 是从 Uncaria tomentosa 分离得到的一种异育亨宾型辛吲哚生物碱,是 M1 型毒蕈碱乙酰胆碱 (muscarinic M1) 受体及 5-HT2 受体的正向调节剂。

钩藤碱E名称

• 中文名: 钩藤碱e
• 英文名: uncarine e

钩藤碱E生物活性

• 描述: Isopteropodine 是从 Uncaria tomentosa 分离得到的一种异育亨宾型辛吲哚生物碱,是 M1 型毒蕈碱乙酰胆碱 (muscarinic M1) 受体及 5-HT2 受体的正向调节剂。
• 相关类别:
  信号通路 >> 神经信号通路 >> mAChR
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 由mAChR
  研究领域 >> 神经疾病
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体
  信号通路 >> 神经信号通路 >> 5-HT受体
• 靶点实验:

  5-HT2 Receptor

• 参考文献:

  [1]. Tai-Hyun Kang,etc. Pteropodine and isopteropodine positively modulate the function of rat muscarinic M1 and 5-HT2 receptors expressed in Xenopus oocyte. European Journal of Pharmacology, Volume 444, Issues 1–2, 2002, Pages 39-45, ISSN 0014-2999,

钩藤碱E物理化学性质

• 密度: 1.33g/cm3
• 沸点: 555.2ºC at 760 mmHg
• 熔点: 209-211 °C
• 分子式: C₂₁H₂₄N₂O₄
• 分子量: 368.42600
• 闪点: 289.6ºC
• 精确质量: 368.17400
• PSA: 67.87000
• LogP: 2.13840
• InChIKey: JMIAZDVHNCCPDM-PFDNRQJHSA-N
• SMILES: COC(=O)C1=COC(C)C2CN3CCC4(C(=O)Nc5ccccc54)C3CC12
• 外观性状: 粉末
• 折射率: 1.635
• 储存条件: 2-8°C，密封，干燥

钩藤碱E安全信息

• 符号: GHS06
• 信号词: Danger
• 危害声明: H300
• 警示性声明: Missing Phrase - N15.00950417
• 危险品运输编码: NONH for all modes of transport

钩藤碱E靶点实验

查看更多实验

实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：ERK5 transcriptional activity HTS 来源：24565 靶标：N/A External Id：ERK5 transcriptional activity-HTS

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：High throughput fluorescence intensity-based biochemical assay to screen for small mo... 来源：University of Pittsburgh Molecular Library Screening Center 靶标：furin (paired basic amino acid cleaving enzyme), isoform CRA_a [Homo sapiens] External Id：MH080376 Biochemical HTS for Inhibitors of the Proprotein Convertase Furin.

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect... 来源：Broad Institute 靶标：N/A External Id：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify pos... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

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钩藤碱E英文别名

• Isopteropodine