商陆皂苷乙

• 常用名: 商陆皂苷乙
• 英文名: Esculentoside B
• CAS号: 60820-94-2
• 分子量: 664.82
• 密度: 1.3±0.1 g/cm3
• 沸点: 779.3±60.0 °C at 760 mmHg
• 分子式: C₃₆H₅₆O₁₁
• 熔点: N/A
• 闪点: 237.0±26.4 °C

商陆皂苷乙用途

Esculentoside B (Phytolaccoside B) 是来源于 Phytolacca acinosa Roxb 根部的天然产物。Esculentoside B 对斑马鱼幼鱼具有神经毒性,并损害其中枢神经系统发育。Esculentoside B 抑制炎症反应,具有抗真菌 (antifungal) 活性。

商陆皂苷乙名称

• 中文名: 美商陆皂苷 B
• 英文名: Phytolaccoside B

商陆皂苷乙生物活性

• 描述: Esculentoside B (Phytolaccoside B) 是来源于 Phytolacca acinosa Roxb 根部的天然产物。Esculentoside B 对斑马鱼幼鱼具有神经毒性,并损害其中枢神经系统发育。Esculentoside B 抑制炎症反应,具有抗真菌 (antifungal) 活性。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 真菌
  研究领域 >> 炎症/免疫
  研究领域 >> 神经疾病
  信号通路 >> MAPK/ERK信号通路 >> JNK
  信号通路 >> 神经信号通路 >> 疼痛
• 参考文献:

  [1]. Abekura F, et al. Esculentoside B inhibits inflammatory response through JNK and downstream NF-κB signaling pathway in LPS-triggered murine macrophage RAW 264.7 cells. Int Immunopharmacol. 2019;68:156-163.

  [2]. Ren S, et al. Metabolic exploration of the developmental abnormalities and neurotoxicity of Esculentoside B, the main toxic factor in Phytolaccae radix. Food Chem Toxicol. 2023;176:113777.

  [3]. Escalante A, et al. Evidence for the mechanism of action of the antifungal phytolaccoside B isolated from Phytolacca tetramera Hauman. J Nat Prod. 2008;71(10):1720-1725.

商陆皂苷乙物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 779.3±60.0 °C at 760 mmHg
• 分子式: C₃₆H₅₆O₁₁
• 分子量: 664.82
• 闪点: 237.0±26.4 °C
• 精确质量: 664.382263
• PSA: 183.21000
• LogP: 5.47
• InChIKey: SFZVDNKTWPZIJG-ODXMFREGSA-N
• SMILES: COC(=O)C1(C)CCC2(C(=O)O)CCC3(C)C(=CCC4C5(C)CC(O)C(OC6OCC(O)C(O)C6O)C(C)(CO)C5CCC43C)C2C1
• 外观性状: 粉末
• 蒸汽压: 0.0±6.1 mmHg at 25°C
• 折射率: 1.600
• 储存条件: 2-8℃，干燥，密闭

商陆皂苷乙安全信息

• 危害码 (欧洲): Xi

商陆皂苷乙靶点实验

查看更多实验

实验名称：Antifungal activity against Aspergillus niger ATCC 9029 after 48 hrs by spectrophotom... 来源：ChEMBL 靶标：Aspergillus niger External Id：CHEMBL1032331

实验名称：Antifungal activity against Saccharomyces cerevisiae ATCC 9763 after 48 hrs by sorbit... 来源：ChEMBL 靶标：Saccharomyces cerevisiae External Id：CHEMBL1032333

实验名称：Antifungal activity against Candida albicans ATCC 10231 after 48 hrs by spectrophotom... 来源：ChEMBL 靶标：Candida albicans External Id：CHEMBL1032332

实验名称：Enhancement of chitin synthase 1 activity in Neurospora crassa assessed as increase i... 来源：ChEMBL 靶标：Chitin synthase 1 External Id：CHEMBL1034997

实验名称：Effect on chitin synthase 1-mediated incorporation of [14C]N-acetylglucosamine in Sac... 来源：ChEMBL 靶标：Chitin synthase 1 External Id：CHEMBL1032339

实验名称：Effect on chitin synthase 1-mediated incorporation of [14C]N-Acetylglucosamine in Sac... 来源：ChEMBL 靶标：Chitin synthase 1 External Id：CHEMBL1032340

实验名称：Antifungal activity against Aspergillus fumigatus ATCC 26934 after 48 hrs by spectrop... 来源：ChEMBL 靶标：Aspergillus fumigatus External Id：CHEMBL1032335

实验名称：Antifungal activity against Cryptococcus neoformans ATCC 32264 after 48 hrs by spectr... 来源：ChEMBL 靶标：Cryptococcus neoformans External Id：CHEMBL1032334

实验名称：Effect on (1->3)-beta-D-glucan synthase-mediated [14C]-Glucose incorporation in Sacch... 来源：ChEMBL 靶标：N/A External Id：CHEMBL1032337

实验名称：Antifungal activity against Aspergillus flavus ATCC 9170 after 48 hrs by spectrophoto... 来源：ChEMBL 靶标：Aspergillus flavus External Id：CHEMBL1032336

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商陆皂苷乙英文别名

• EsculentosideB
• (2β,3β)-2,23-Dihydroxy-30-methoxy-30-oxo-3-(β-D-xylopyranosyloxy)olean-12-en-28-oic acid