7-木糖甙-10-脱乙酰基紫杉醇

• 常用名: 7-木糖甙-10-脱乙酰基紫杉醇
• 英文名: 10-Deacetyl-7-xylosyl paclitaxel
• CAS号: 90332-63-1
• 分子量: 943.984
• 密度: 1.5±0.1 g/cm3
• 沸点: 1068.4±65.0 °C at 760 mmHg
• 分子式: C₅₀H₅₇NO₁₇
• 熔点: N/A
• 闪点: 599.9±34.3 °C

7-木糖甙-10-脱乙酰基紫杉醇用途

10-Deacetyl-7-xylosyl paclitaxel是Paclitaxel的衍生物,相比Paclitaxel,具有更好的药学活性和水溶性。

7-木糖甙-10-脱乙酰基紫杉醇名称

• 中文名: 7-木糖甙-10-脱乙酰基紫杉醇
• 英文名: 7-Xylosyl-10-deacetyltaxol
• 中文别名: 7-木糖-10-去乙酰基紫杉醇 | 7-木糖苷-10-脱乙酰基紫杉醇

7-木糖甙-10-脱乙酰基紫杉醇生物活性

• 描述: 10-Deacetyl-7-xylosyl paclitaxel是Paclitaxel的衍生物,相比Paclitaxel,具有更好的药学活性和水溶性。
• 相关类别:
  信号通路 >> 抗体- 药物偶联物 >> ADC细胞毒素
  信号通路 >> 细胞周期/DNA损伤 >> 微管/微管蛋白
  信号通路 >> 细胞骨架 >> 微管/微管蛋白
  研究领域 >> 癌症
• 参考文献:

  [1]. Jiang S, et al. Activation of the mitochondria-driven pathway of apoptosis in human PC-3 prostate cancer cells by a novel hydrophilic paclitaxel derivative, 7-xylosyl-10-deacetylpaclitaxel. Int J Oncol. 2008 Jul;33(1):103-11.

7-木糖甙-10-脱乙酰基紫杉醇物理化学性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 1068.4±65.0 °C at 760 mmHg
• 分子式: C₅₀H₅₇NO₁₇
• 分子量: 943.984
• 闪点: 599.9±34.3 °C
• 精确质量: 943.362671
• PSA: 274.14000
• LogP: 7.18
• InChIKey: ORKLEZFXASNLFJ-ZJHBZJGDSA-N
• SMILES: CC(=O)OC12COC1CC(OC1OCC(O)C(O)C1O)C1(C)C(=O)C(O)C3=C(C)C(OC(=O)C(O)C(NC(=O)c4ccccc4)c4ccccc4)CC(O)(C(OC(=O)c4ccccc4)C21)C3(C)C
• 蒸汽压: 0.0±0.3 mmHg at 25°C
• 折射率: 1.660
• 储存条件: 2-8℃

7-木糖甙-10-脱乙酰基紫杉醇靶点实验

查看更多实验

实验名称：Antiproliferative activity against human A549 cells assessed as growth inhibition aft... 来源：ChEMBL 靶标：A549 External Id：CHEMBL3399186

实验名称：Antiproliferative activity against human HepG2 cells assessed as growth inhibition af... 来源：ChEMBL 靶标：HepG2 External Id：CHEMBL3399189

实验名称：Antiproliferative activity against human A2780 cells assessed as growth inhibition af... 来源：ChEMBL 靶标：A2780 External Id：CHEMBL3399190

实验名称：Antiproliferative activity against human SW480 cells assessed as growth inhibition af... 来源：ChEMBL 靶标：SW480 External Id：CHEMBL3399187

实验名称：Antiproliferative activity against human MCF7 cells assessed as growth inhibition aft... 来源：ChEMBL 靶标：MCF7 External Id：CHEMBL3399188

实验名称：Antiproliferative activity against human HCT8/VCT cells assessed as growth inhibition... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3399193

实验名称：Antiproliferative activity against human A549/CDDP cells assessed as growth inhibitio... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3399194

实验名称：Antiproliferative activity against human A2780/TAX cells assessed as growth inhibitio... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3399191

实验名称：Antiproliferative activity against human HCT8 cells assessed as growth inhibition aft... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3399192

实验名称：Antiproliferative activity against human MCF7/DX cells assessed as growth inhibition ... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3399195

共11条，当前第1页，共2页

1

2

7-木糖甙-10-脱乙酰基紫杉醇英文别名

• (2α,3β,5β,7β,10β,13α)-4-Acetoxy-13-{[(2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoyl]oxy}-1,10-dihydroxy-9-oxo-7-(β-D-xylopyranosyloxy)-5,20-epoxytax-11-en-2-yl benzoate
• (2α,5β,7β,10β,13α)-4-Acetoxy-13-{[(2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoyl]oxy}-1,10-dihydroxy-9-oxo-7-(β-D-xylopyranosyloxy)-5,20-epoxytax-11-en-2-yl benzoate
• 10-Deacetyl-7-xylosyl paclitaxel