90332-63-1

• 常用中文名：7-木糖甙-10-脱乙酰基紫杉醇
• 常用英文名：10-Deacetyl-7-xylosyl paclitaxel
• CAS号：90332-63-1
• 分子式：C₅₀H₅₇NO₁₇
• 分子量：943.984
• 相关类别： 天然产物 萜类
• 发布时间：2019-01-09 22:15:46
• 更新时间：2026-07-10 21:59:51
• 10-Deacetyl-7-xylosyl paclitaxel是Paclitaxel的衍生物,相比Paclitaxel,具有更好的药学活性和水溶性。

名称

• 中文名: 7-木糖甙-10-脱乙酰基紫杉醇
• 英文名: 7-Xylosyl-10-deacetyltaxol
• 中文别名: 木糖苷-10-脱乙酰基紫杉醇; 7-木糖甙-10-脱乙酰基紫杉醇,10 MM DMSO 溶液; 10-DEACETYL-7-XYLOSYL PACLITAXEL7-木糖甙-10-脱乙酰基紫杉醇; 7-木糖-10-去乙酰基紫杉醇; 7-木糖-10-去乙酰紫杉醇; 10-去乙酰-7-木糖紫杉醇/萜类; 10-去乙酰-7-木糖紫杉醇; BSA-7-木糖紫杉醇; 7-木糖紫杉醇(7木糖10去乙酰基紫杉醇); 7-木糖苷-10-脱乙酰基紫杉醇; 7-木糖苷-10-脱乙酰基紫杉醇标准品; 10-Deacetyl-7-xylosyl paclitaxel :7-木糖基-10-去乙酰基紫杉醇; 7-木糖苷-10-脱乙酰基; 7-木糖基-10-去乙酰基紫杉醇
• 英文别名: Paclitaxel Impurity 49; DEACETYL-7-XYLOTAXOL, 10-(P); 10-Deacetylpaclitaxel 7-Xyloside; (2α,3β,5β,7β,10β,13α)-4-Acetoxy-13-{[(2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoyl]oxy}-1,10-dihydroxy-9-oxo-7-(β-D-xylopyranosyloxy)-5,20-epoxytax-11-en-2-yl benzoate; Deacetyl-7-Xyloslytaxol, 10; b-(Benzoylamino)-a-hydroxy-benzenepropanoic acid [2-[2aa,4b,4ab,6b,9a*,bS*),11a,12a,12aa,12ba]]-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-6,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-4-(b-D-xylopyranosyloxy)-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester; 10-Deacetyltaxol 7-xyloside; 10-Deacetyl-7-xylosyl paclitaxel, 10 mM in DMSO; 7-XYLOXYL-10-DEACETYL TAXOL; 7-Xylose-10-deacetyltaxol; Paclitaxel Impurity 92; (2α,5β,7β,10β,13α)-4-Acetoxy-13-{[(2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoyl]oxy}-1,10-dihydroxy-9-oxo-7-(β-D-xylopyranosyloxy)-5,20-epoxytax-11-en-2-yl benzoate; 7-XYLOSYL-10-DEACETYLTAXOL; benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, (2,4S,4aS,6R,9S,11S,12S,12,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-6,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-4-(β-D-xylopyranosyloxy)-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS); 10-O-Deacetyl-7-O-(beta-xylosyl)paclitaxel; 10-O-Deacetyl-7-O-(β-xylosyl)paclitaxel; 7-xyloside-10 deacetylpaclitaxel; benzenepropanoic acid, b-(benzoylaMino)-a-hydroxy-,(2,4S,4aS,6R,9S,11S,12S,12,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-6,11-dihydroxy-4a,8,13,13-tetraMethyl-5-oxo-4-(b-D-xylopyranosyloxy)-7,11-Methano-1H-cyclo; 10-Deacetyl-7-xylosyl Paclitaxel; Paliperidone Impurity 51

物化性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 1068.4±65.0 °C at 760 mmHg
• 分子式: C₅₀H₅₇NO₁₇
• 分子量: 943.984
• 闪点: 599.9±34.3 °C
• 精确质量: 943.362671
• PSA: 274.14000
• LogP: 7.18
• 蒸汽压: 0.0±0.3 mmHg at 25°C
• 折射率: 1.660
• 储存条件: 2-8℃

生物活性

• 描述: 10-Deacetyl-7-xylosyl paclitaxel是Paclitaxel的衍生物,相比Paclitaxel,具有更好的药学活性和水溶性。
• 相关类别:
  信号通路 >> 抗体- 药物偶联物 >> ADC细胞毒素
  信号通路 >> 细胞周期/DNA损伤 >> 微管/微管蛋白
  信号通路 >> 细胞骨架 >> 微管/微管蛋白
  研究领域 >> 癌症
• 参考文献:

  [1]. Jiang S, et al. Activation of the mitochondria-driven pathway of apoptosis in human PC-3 prostate cancer cells by a novel hydrophilic paclitaxel derivative, 7-xylosyl-10-deacetylpaclitaxel. Int J Oncol. 2008 Jul;33(1):103-11.