90332-63-1

• 常用中文名：7-木糖甙-10-脱乙酰基紫杉醇
• 常用英文名：10-Deacetyl-7-xylosyl paclitaxel
• CAS号：90332-63-1
• 分子式：C₅₀H₅₇NO₁₇
• 分子量：943.984
• 相关类别： 天然产物 萜类
• 发布时间：2019-01-09 22:15:46
• 更新时间：2024-01-04 21:46:47
• 10-Deacetyl-7-xylosyl paclitaxel是Paclitaxel的衍生物,相比Paclitaxel,具有更好的药学活性和水溶性。

名称

• 中文名: 7-木糖甙-10-脱乙酰基紫杉醇
• 英文名: 7-Xylosyl-10-deacetyltaxol
• 中文别名: 7-木糖-10-去乙酰基紫杉醇; 7-木糖苷-10-脱乙酰基紫杉醇
• 英文别名: Benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-6,11-dihydroxy-4a,8,13,13-t etramethyl-5-oxo-4-(β-D-xylopyranosyloxy)-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-; (2α,3β,5β,7β,10β,13α)-4-Acetoxy-13-{[(2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoyl]oxy}-1,10-dihydroxy-9-oxo-7-(β-D-xylopyranosyloxy)-5,20-epoxytax-11-en-2-yl benzoate; (2α,5β,7β,10β,13α)-4-Acetoxy-13-{[(2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoyl]oxy}-1,10-dihydroxy-9-oxo-7-(β-D-xylopyranosyloxy)-5,20-epoxytax-11-en-2-yl benzoate; Benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aS,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-6,11-dihydroxy-4a,8,13,13-t etramethyl-5-oxo-4-(β-D-xylopyranosyloxy)-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-; 10-Deacetyl-7-xylosyl paclitaxel

物化性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 1068.4±65.0 °C at 760 mmHg
• 分子式: C₅₀H₅₇NO₁₇
• 分子量: 943.984
• 闪点: 599.9±34.3 °C
• 精确质量: 943.362671
• PSA: 274.14000
• LogP: 7.18
• 蒸汽压: 0.0±0.3 mmHg at 25°C
• 折射率: 1.660
• 储存条件: 2-8℃

生物活性

• 描述: 10-Deacetyl-7-xylosyl paclitaxel是Paclitaxel的衍生物,相比Paclitaxel,具有更好的药学活性和水溶性。
• 相关类别:
  信号通路 >> 抗体- 药物偶联物 >> ADC细胞毒素
  信号通路 >> 细胞周期/DNA损伤 >> 微管/微管蛋白
  信号通路 >> 细胞骨架 >> 微管/微管蛋白
  研究领域 >> 癌症
• 参考文献:

  [1]. Jiang S, et al. Activation of the mitochondria-driven pathway of apoptosis in human PC-3 prostate cancer cells by a novel hydrophilic paclitaxel derivative, 7-xylosyl-10-deacetylpaclitaxel. Int J Oncol. 2008 Jul;33(1):103-11.