N-Acetyl-L-tyrosine

N-Acetyl-L-tyrosine Structure
N-Acetyl-L-tyrosine structure
Common Name N-Acetyl-L-tyrosine
CAS Number 537-55-3 Molecular Weight 223.225
Density 1.3±0.1 g/cm3 Boiling Point 531.3±45.0 °C at 760 mmHg
Molecular Formula C11H13NO4 Melting Point 149-152 °C(lit.)
MSDS Chinese USA Flash Point 275.1±28.7 °C
Symbol GHS05
GHS05
Signal Word Danger

Surfactants, aromatic and isoprenoid compounds, and fatty acid biosynthesis inhibitors suppress Staphylococcus aureus production of toxic shock syndrome toxin 1.

Antimicrob. Agents Chemother. 53 , 1898-906, (2009)

Menstrual toxic shock syndrome is a rare but potentially life-threatening illness manifest through the actions of Staphylococcus aureus toxic shock syndrome toxin 1 (TSST-1). Previous studies have shown that tampon additives can influence staphylococcal TSST-...

Detection of autosomal dominant polycystic kidney disease by NMR spectroscopic fingerprinting of urine.

Kidney Int. 79(11) , 1244-53, (2011)

Autosomal dominant polycystic kidney disease (ADPKD) is a frequent cause of kidney failure; however, urinary biomarkers for the disease are lacking. In a step towards identifying such markers, we used multidimensional-multinuclear nuclear magnetic resonance (...

Newborn screening for congenital adrenal hyperplasia: additional steroid profile using liquid chromatography-tandem mass spectrometry.

J. Clin. Endocrinol. Metab. 92(7) , 2581-9, (2007)

Neonatal screening programs for congenital adrenal hyperplasia (21-CAH) using an immunoassay for 17alpha-hydroxyprogesterone (17-OHP) generate a high rate of positive results attributable to physiological reasons and to cross-reactions with steroids other tha...

Utilization of tyrosine-containing dipeptides and N-acetyl-tyrosine in hepatic failure.

Hepatology 21(4) , 923-8, (1995)

The impact of hepatic dysfunction on the elimination and hydrolysis of three potential tyrosine sources for total parenteral nutrition, the dipeptides L-alanyl-L-tyrosine (Ala-Tyr) and glycyl-L-tyrosine (Gly-Tyr), and N-acetyl-L-tyrosine (Nac-Tyr) were evalua...

Influence of alkyl group on amide nitrogen atom on fluorescence quenching of tyrosine amide and N-acetyltyrosine amide.

Biophys. Chem. 111(2) , 105-13, (2004)

The steady-state and time-resolved fluorescence spectroscopy was applied to determine the influence of an alkyl substituent(s) (methyl or ethyl, n-propyl, iso-propyl, n-butyl, sec-butyl, or t-butyl) on amide nitrogen atom on photophysical properties of tyrosi...

N-Glycans protect proteins from protease digestion through their binding affinities for aromatic amino acid residues.

J. Biochem. 127(3) , 427-33, (2000)

It was previously revealed [Yamaguchi, H., Nishiyama, T., and Uchida, M. (1999) J. Biochem. 126, 261-265] that N-glycans of both the high-mannose and complex types have binding affinity for aromatic amino acid residues. This study shows that free N-glycans pr...

Chlorination of N-acetyltyrosine with HOCl, chloramines, and myeloperoxidase-hydrogen peroxide-chloride system.

Acta Biochim. Pol. 48(1) , 271-5, (2001)

N-acetyl-L-tyrosine (N-acTyr), with the alpha amine residue blocked by acetylation, can mimic the reactivity of exposed tyrosyl residues incorporated into polypeptides. In this study chlorination of N-acTyr residue at positions 3 and 5 in reactions with NaOCl...

Estimation of serum alpha 2-macroglobulin based on the esterolytic activity of bound alpha-chymotrypsin.

Biochem. Med. 32(3) , 357-63, (1984)

A colorimetric method to estimate alpha 2-macroglobulin (MG) in human serum is described which is based on the capacity of MG:alpha-chymotrypsin complex to hydrolyze N-acetyl L-tyrosine ethyl ester in the presence of excess crude preparation of a trypsin/chym...

Effect of 3-hydroxyanthranilic acid on mushroom tyrosinase activity.

Biochim. Biophys. Acta 1384(2) , 268-76, (1998)

Tyrosinase is a copper containing protein which catalyzes the hydroxylation of monophenols and the oxidation of diphenols to o-quinones. The monophenolase activity of tyrosinase is characterized by a typical lag time. In this paper the influence of 3-hydroxya...

N-acetyl tyrosyluria caused by parenteral or enteral administration of N-acetyl-L-tyrosine: differentiation from hereditary and acquired tyrosinemias.

J. Pediatr. Gastroenterol. Nutr. 39(1) , 95-100, (2004)