Radicicol
Radicicol structure
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Common Name | Radicicol | ||
|---|---|---|---|---|
| CAS Number | 12772-57-5 | Molecular Weight | 364.777 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 656.2±55.0 °C at 760 mmHg | |
| Molecular Formula | C18H17ClO6 | Melting Point | 190-194ºC | |
| MSDS | Chinese USA | Flash Point | 350.7±31.5 °C | |
| Symbol |
GHS06, GHS08 |
Signal Word | Danger | |
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Screening for negative effects of candidate ascidian antifoulant compounds on a target aquaculture species, Perna canaliculus Gmelin.
Biofouling 29(1) , 29-37, (2013) The natural chemical compounds radicicol, polygodial and ubiquinone-10 (Q10) have previously been identified as inhibitors of metamorphosis in ascidian larvae. Accordingly, they have potential as a specific remedy for the costly problem of fouling ascidians i... |
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[Thermosensitization of tumor cells with inhibitors of chaperone activity and expression].
Biomed. Khim. 58(6) , 662-72, (2012) Effects of inhibitors of the heat shock protein 90 (HSP90) chaperone activity and inhibitors of the heat shock protein (HSP) expression on sensitivity of HeLa tumor cells to hyperthermia were studied. It was found that nanomolar concentrations of inhibitors o... |
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Geldanamycin and its derivatives as Hsp90 inhibitors.
Front. Biosci. (Landmark Ed.) 17 , 2269-77, (2012) The Hsp90 molecule, one of the most abundant heat shock proteins in mammalian cells, maintains homeostasis and prevents stress-induced cellular damage. Hsp90 is expressed under normal conditions at a level of about 1-2 Percent of total proteins, while its exp... |
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Loss of tumor suppressor NF1 activates HSF1 to promote carcinogenesis.
J. Clin. Invest. 122(10) , 3742-54, (2012) Intrinsic stress response pathways are frequently mobilized within tumor cells. The mediators of these adaptive mechanisms and how they contribute to carcinogenesis remain poorly understood. A striking example is heat shock factor 1 (HSF1), master transcripti... |
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Radicicol, an inhibitor of Hsp90, enhances TRAIL-induced apoptosis in human epithelial ovarian carcinoma cells by promoting activation of apoptosis-related proteins.
Mol. Cell Biochem. 359(1-2) , 33-43, (2012) Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces apoptosis in various cancer cells. Hsp90 is known to be involved in cell survival and growth in tumor cells. Nevertheless, Hsp90 inhibitors exhibit a variable effect on the cytotoxicity o... |
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18β-glycyrrhetinic acid potentiates Hsp90 inhibition-induced apoptosis in human epithelial ovarian carcinoma cells via activation of death receptor and mitochondrial pathway.
Mol. Cell Biochem. 370(1-2) , 209-19, (2012) The Hsp90 inhibition has been shown to induce apoptosis in various cancer cells. The licorice compounds may enhance the anti-cancer drug effect. However, effect of the licorice compounds on the Hsp90 inhibition-induced apoptosis in ovarian cancer cells has no... |
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Identification of compounds protective against G93A-SOD1 toxicity for the treatment of amyotrophic lateral sclerosis.
Amyotroph. Lateral Scler. 12(2) , 87-96, (2011) The underlying cause of amyotrophic lateral sclerosis (ALS), a progressive neurodegenerative disorder, remains unknown. However, there is strong evidence that one pathophysiological mechanism, toxic protein misfolding and/or aggregation, may trigger motor neu... |
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Regulation of RNA interference by Hsp90 is an evolutionarily conserved process
Biochim. Biophys. Acta 1833(12) , 2673-81, (2013) RNAi is a highly conserved mechanism in almost every eukaryote with a few exceptions including the model organism Saccharomyces cerevisiae. A recent study showed that the introduction of the two core components of canonical RNAi systems, Argonaute and Dicer, ... |
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Hsp90 regulates O-linked β-N-acetylglucosamine transferase: a novel mechanism of modulation of protein O-linked β-N-acetylglucosamine modification in endothelial cells.
Am. J. Physiol. Cell Physiol. 302(12) , C1786-96, (2012) O-linked β-N-acetylglucosamine (O-GlcNAc) modification of proteins is involved in many important cellular processes. Increased O-GlcNAc has been implicated in major diseases, such as diabetes and its complications and cardiovascular and neurodegenerative dise... |
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Inhibition of HSP90-dependent telomerase activity in amyloid β-induced apoptosis of cerebral endothelial cells.
J. Cell Physiol. 226(8) , 2041-51, (2011) Although apoptosis induced by amyloid β (Aβ) has been identified, the effect of Aβ on telomerase activity in relation to apoptosis induction remains unclear. In the present study, Aβ(1-40) and Aβ(25-35), but not Aβ(1-16) and Aβ(35-25), reduce the viability of... |