Khellin
Khellin structure
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Common Name | Khellin | ||
|---|---|---|---|---|
| CAS Number | 82-02-0 | Molecular Weight | 260.242 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 482.1±0.0 °C at 760 mmHg | |
| Molecular Formula | C14H12O5 | Melting Point | 150-154ºC | |
| MSDS | Chinese USA | Flash Point | 218.8±28.7 °C | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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Validated HPLC and HPTLC methods for simultaneous determination of colchicine and khellin in pharmaceutical formulations.
J. Chromatogr. Sci. 51(3) , 258-65, (2013) The present work describes validated high-performance liquid chromatography (HPLC) and high-performance thin-layer chromatography (HPTLC) methods for the simultaneous determination of colchicine and khellin. The isocratic reversed-phase HPLC separation was pe... |
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F420H2-dependent degradation of aflatoxin and other furanocoumarins is widespread throughout the actinomycetales.
PLoS ONE 7(2) , e30114, (2012) Two classes of F(420)-dependent reductases (FDR-A and FDR-B) that can reduce aflatoxins and thereby degrade them have previously been isolated from Mycobacterium smegmatis. One class, the FDR-A enzymes, has up to 100 times more activity than the other. F(420)... |
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A case study to evaluate the treatment of vitiligo with khellin encapsulated in L-phenylalanin stabilized phosphatidylcholine liposomes in combination with ultraviolet light therapy.
Eur. J. Dermatol. 13(5) , 474-7, (2003) Vitiligo destroys the melanocytes in the epidermis; the inactive melanocytes in the outer root sheaths are not affected. Phosphatidylcholine liposomes are able to target molecules contained in them into the hair follicles. Khellin is activated by UVA and prev... |
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Application of 1D BIRD or X-filtered DEPT long-range C-C relay for detection of proton and carbon via four bonds and measuring long-range 13C-13C coupling constants.
Magn. Reson. Chem. 44(4) , 475-80, (2006) We propose the 13C-detecting 1D DEPT long-range C-C relay to detect super long-range H-C connectivity via four bonds (1H-13C-X-X-13C, X represents 12C or heteronuclear). It is derived from the DEPT C-C relay which detects the H-C correlations via two bonds (1... |
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Computational study of khellin excited states and photobinding to DNA.
Photochem. Photobiol. Sci. 8(8) , 1179-86, (2009) A theoretical investigation of the formation and spectroscopic properties of the furan and pyrone monoadducts between the photosensitizer khellin and DNA base thymine is reported. The thermal reaction pathways involve very high barriers, whereas the excited s... |
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Determination of visnagin in rat plasma by liquid chromatography with tandem mass spectrometry and its application to in vivo pharmacokinetic studies.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 877(7) , 653-6, (2009) A rapid and sensitive method for the determination of visnagin in rat plasma was developed using liquid chromatography tandem mass spectrometry (LC-MS/MS). The plasma samples were processed by protein precipitation with methanol:acetonitrile (25:75) and warfa... |
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Nanosecond time-resolved infrared studies of visnagin and khellin triplets and radical ions.
J. Phys. Chem. A 109(41) , 9206-12, (2005) Time-resolved infrared spectroscopy (TRIR) and density functional theory (DFT) calculations were used to directly observe and assign the vibrational spectra of the triplet states of visnagin and khellin, and to investigate their electron-transfer chemistry. T... |
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Topical khellin and natural sunlight in the outpatient treatment of recalcitrant palmoplantar pompholyx: report of an open pilot study.
Dermatology 211(4) , 381-3, (2005)
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Fluorometric determination of khellin in human urine and serum by high-performance liquid chromatography using postcolumn photoirradiation.
Anal. Sci. 19(7) , 1071-3, (2003) For the determination of khellin in urine and serum, fluorometry using HPLC-postcolumn photoirradiation has been developed. Khellin and visnagin of similar structure were separated on a column of Capcell Pak C8. The mobile phase consisted of 40%(v/v) ethanol ... |
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Antitumor and antimicrobial activities of some hetero aromatic benzofurans derived from naturally occurring visnagin.
Acta Pol. Pharm. 69(4) , 645-55, (2012) Bromination of visnaginone (1) yielded the dibromo derivative (2), which upon methylation with methyl iodide gave 1-(2,7-dibromo-4,6-dimethoxybenzofuran-5-yl) ethanone (3). Compound (3) reacted with dimethylformamide dimethylacetal to give (4). The reaction o... |