Citraconic anhydride
Citraconic anhydride structure
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Common Name | Citraconic anhydride | ||
|---|---|---|---|---|
| CAS Number | 616-02-4 | Molecular Weight | 112.08300 | |
| Density | 1.247 g/mL at 25 °C(lit.) | Boiling Point | 213-214 °C(lit.) | |
| Molecular Formula | C5H4O3 | Melting Point | 6-10 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 215 °F | |
| Symbol |
GHS05, GHS06, GHS08 |
Signal Word | Danger | |
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MALDI imaging mass spectrometry profiling of N-glycans in formalin-fixed paraffin embedded clinical tissue blocks and tissue microarrays.
PLoS ONE 9(9) , e106255, (2014) A recently developed matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI-IMS) method to spatially profile the location and distribution of multiple N-linked glycan species in frozen tissues has been extended and improved for the direc... |
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Polymeric micelles with citraconic amide as pH-sensitive bond in backbone for anticancer drug delivery.
Int. J. Pharm. 471(1-2) , 28-36, (2014) A novel pH-sensitive polymeric micelle was reported. Methoxy poly(ethylene glycol)-b-poly(ϵ-caprolactone) copolymer with citraconic amide as pH-sensitive bond was synthesized (mPEG-pH-PCL). The copolymers self-assembled into micelles to encapsulate anticancer... |
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Pre-cultivation of adipose tissue-derived microvascular fragments in porous scaffolds does not improve their in vivo vascularisation potential.
Eur. Cell. Mater. 29 , 190-200; discussion 200-1, (2015) Adipose tissue-derived microvascular fragments represent promising vascularisation units for implanted tissue constructs. However, their reassembly into functional microvascular networks takes several days, during which the cells inside the implants are expos... |
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Experimental colitis in SIV-uninfected rhesus macaques recapitulates important features of pathogenic SIV infection.
Nat. Commun. 6 , 8020, (2015) Mucosal damage to the gastrointestinal (GI) tract with resulting microbial translocation is hypothesized to significantly contribute to the heightened and persistent chronic inflammation and immune activation characteristic to HIV infection. Here we employ a ... |
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Dual-targeting and pH/redox-responsive multi-layered nanocomplexes for smart co-delivery of doxorubicin and siRNA.
Biomaterials 60 , 42-52, (2015) Multi-layered nanocomplexes (MLNs) were designed here to provide smart co-delivery of doxorubicin (DOX) and vascular endothelial growth factor (VEGF) siRNA. The electrostatically self-assembled MLNs were constructed by TAT peptide modified mesoporous silica n... |
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Purification and characterization of four monofluorescein cobra alpha-toxin derivatives.
J. Biol. Chem. 263(6) , 2802-7, (1988) We labeled cobra-alpha-toxin (Naja naja siamensis 3) with near stoichiometric quantities of fluorescein isothiocyanate. To reduce labeling of the hyperreactive N epsilon-lysine 23, the alpha-toxin was modified reversibly with citraconic anhydride before fluor... |
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Stepwise modification of lysine residues of glucose oxidase with citraconic anhydride.
Int. J. Biol. Macromol. 39(4-5) , 192-6, (2006) Structural properties of modified forms of glucose oxidase made by stepwise specific modification have been investigated. By a single step modification, one of the modified forms resulted in the conversion of native structure of glucose oxidase to molten glob... |
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Schistosoma mansoni: chemical stabilization of cercariae by aldehydes.
Exp. Parasitol. 64(1) , 111-9, (1987) Chemically stabilized cercariae of Schistosoma mansoni have been developed by inactivating surface glycoproteins which are essential for their survival. The inactivation was achieved by reaction with 0.01-0.1% glutaraldehyde, 0.1-1% formaldehyde, and 0.37-3.7... |
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Regeneration of native ovalbumin conformation disrupted by citraconylation.
Biochimie 73(11) , 1397-402, (1991) Ovalbumin was reacted with a 960-fold molar excess of citraconic anhydride, and 91% of the epsilon-amino groups, representing 18 of the 20 lysine residues, were citraconylated. As detected by fluorescence and far-ultraviolet circular dichroic (CD) measurement... |
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Citraconylation--a simple method for high protein sequence coverage in MALDI-TOF mass spectrometry.
Biochem. Biophys. Res. Commun. 305(4) , 1091-3, (2003) Lysine epsilon -amino group reacts with citraconic anhydride forming a derivative, which is stable on terms for trypsin cleavage. This modification changes the spectrum of peptides formed by the trypsin action; as the number of trypsin-sensitive sites is redu... |