Fluoxymesterone
Fluoxymesterone structure
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Common Name | Fluoxymesterone | ||
|---|---|---|---|---|
| CAS Number | 76-43-7 | Molecular Weight | 336.441 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 474.2±45.0 °C at 760 mmHg | |
| Molecular Formula | C20H29FO3 | Melting Point | 240 °C | |
| MSDS | N/A | Flash Point | 240.6±28.7 °C | |
| Symbol |
GHS02, GHS07, GHS08 |
Signal Word | Danger | |
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Rat liver lysosomal and mitochondrial activities are modified by anabolic-androgenic steroids.
Med. Sci Sports Exerc. 31 , 243, (1999) The aim of this study was to examine the separate and combined effects of an 8-wk treatment with high doses of 17alpha-alkylated anabolic-androgenic steroids (AAS) and exercise training on selected lysosomal and mitochondrial enzyme activities in rat liver.Se... |
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Biotransformation of 17-alkyl steroids in the equine: high-performance liquid chromatography-mass spectrometric and gas chromatography-mass spectrometric analysis of fluoxymesterone metabolites in urine samples.
J. Chromatogr. B. Biomed. Sci. Appl. 704 , 119, (1997) In this study the equine metabolism of fluoxymesterone (9alpha-fluoro-11beta-17beta-dihydroxy-17alpha-meth ylandrost-4-ene-3-one) given orally has been investigated. The parent material was not detected, but two major 16-hydroxy metabolites which corresponded... |
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Comparison of chemotherapy with chemohormonal therapy as first-line therapy for metastatic, hormone-sensitive breast cancer: An Eastern Cooperative Oncology Group study.
J. Clin. Oncol. 18(2) , 262-6, (2000) Although hormonal therapy represents standard therapy for metastatic hormone-sensitive disease, many patients receive initial chemotherapy because of the location, bulk, or aggressiveness of their disease. It is uncertain whether simultaneous hormonal therapy... |
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Sample size calculations for the two-sample problem using the multiplicative intensity model.
Stat. Med. 20(4) , 557-79, (2001) In this paper we propose formulae for calculating the expected number of events or, alternatively, the required trial duration, for clinical trials involving two treatment groups in which patients may potentially experience multiple events and the data will b... |
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Toxic effects of anabolic-androgenic steroids in primary rat hepatic cell cultures.
J. Pharmacol. Toxicol. Methods 33(4) , 187-95, (1995) Hepatic complications in athletes and bodybuilders after abusing anabolic-androgenic steroids (AAS) have been reported. Hepatic injury, including cholestasis, peliosis hepatis, hyperplasia, and tumors, have been attributed to abuse of the 17 alpha-alkylated A... |
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Randomized trial of tamoxifen alone or combined with fluoxymesterone as adjuvant therapy in postmenopausal women with resected estrogen receptor positive breast cancer. North Central Cancer Treatment Group Trial 89-30-52.
Breast Cancer Res. Treat. 98(2) , 217-22, (2006) This clinical trial evaluated the addition of fluoxymesterone (Flu) to tamoxifen (Tam) in women with resected early stage breast cancer and attempted to corroborate the findings of superiority for the combination over Tam alone seen in a previous randomized t... |
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Determination of association constants between steroid compounds and albumins by partial-filling ACE.
Electrophoresis 28(20) , 3737-44, (2007) ACE is a popular technique for evaluating association constants between drugs and proteins. However, ACE has not previously been applied to study the association between electrically neutral biomolecules and plasma proteins. We studied the affinity between hu... |
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Optimization and validation of conventional and micellar LC methods for the analysis of methyltestosterone in sugar-coated pills.
J. Pharm. Biomed. Anal. 31(1) , 201-8, (2003) Two isocratic liquid chromatographic methods (conventional and micellar) for the determination of methyltestosterone in sugar-coated pills using fluoxymesterone as internal standard have been developed and validated. In conventional liquid chromatography a mo... |
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Mass spectrometric identification and characterization of new fluoxymesterone metabolites in human urine by liquid chromatography time-of-flight tandem mass spectrometry.
Steroids 77(8-9) , 871-7, (2012) In this study fluoxymesterone urinary profiles were investigated by liquid chromatography quadrupole time-of-flight tandem mass spectrometry (LC-QTOFMS) with accurate mass measurement. Twelve metabolites including the parent drug were detected in two fluoxyme... |
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Characterization and quantification of fluoxymesterone metabolite in horse urine by gas chromatography/mass spectrometry.
Anal. Sci. 24(7) , 911-4, (2008) Fluoxymesterone, an anabolic steroid with the 17alpha-methyl,17beta-hydroxy group, has been developed as an oral formulation for therapeutic purposes. However, it is also used illegally in racehorses to enhance racing performance. In this study, we detected 9... |