2-Picolinic acid
2-Picolinic acid structure
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Common Name | 2-Picolinic acid | ||
|---|---|---|---|---|
| CAS Number | 98-98-6 | Molecular Weight | 123.109 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 292.5±13.0 °C at 760 mmHg | |
| Molecular Formula | C6H5NO2 | Melting Point | 139-142 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 130.7±19.8 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression.
Nature 457(7231) , 910-4, (2009) Multiple, complex molecular events characterize cancer development and progression. Deciphering the molecular networks that distinguish organ-confined disease from metastatic disease may lead to the identification of critical biomarkers for cancer invasion an... |
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Interaction of vanadium(IV) with human serum apo-transferrin.
J. Inorg. Biochem. 121 , 187-95, (2013) The interaction of V(IV)O-salts as well as of a few V(IV)O(carrier)n complexes with human serum transferrin (hTF) is studied focusing on the determination of the nature and stoichiometry of the binding of V(IV)O(2+) to hTF, as well as whether the conformation... |
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Identifying chelators for metalloprotein inhibitors using a fragment-based approach.
J. Med. Chem. 54 , 591-602, (2011) Fragment-based lead design (FBLD) has been used to identify new metal-binding groups for metalloenzyme inhibitors. When screened at 1 mM, a chelator fragment library (CFL-1.1) of 96 compounds produced hit rates ranging from 29% to 43% for five matrix metallop... |
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ECNI GC-MS analysis of picolinic and quinolinic acids and their amides in human plasma, CSF, and brain tissue.
Adv. Exp. Med. Biol. 527 , 705-12, (2003) To study the complex inter-relationships between inflammatory and apoptotic responses and the kynurenine pathway, we have utilized electron-capture negative ion mass spectrometry to develop trace analyses to concurrently quantify nicotinic acid (NIC), picolin... |
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Competitive inhibitors of the CphA metallo-beta-lactamase from Aeromonas hydrophila.
Antimicrob. Agents Chemother. 51 , 2136-42, (2007) Various inhibitors of metallo-beta-lactamases have been reported; however, none are effective for all subgroups. Those that have been found to inhibit the enzymes of subclass B2 (catalytically active with one zinc) either contain a thiol (and show less inhibi... |
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The kynurenine pathway and inflammation in amyotrophic lateral sclerosis.
Neurotox. Res. 18(2) , 132-42, (2010) Amyotrophic lateral sclerosis (ALS) is a progressive and fatal motor neuron disease of unknown pathogenesis. The kynurenine pathway (KP), activated during neuroinflammation, is emerging as a possible contributory factor in ALS. The KP is the major route for t... |
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Behavioral Deficits Are Accompanied by Immunological and Neurochemical Changes in a Mouse Model for Neuropsychiatric Lupus (NP-SLE).
Int. J. Mol. Sci. 16 , 15150-71, (2015) Neuropsychiatric symptoms of systemic lupus erythematosus (NP-SLE) have been understudied compared to end-organ failure and peripheral pathology. Neuropsychiatric symptoms, particularly affective and cognitive indications, may be among the earliest manifestat... |
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Peripheral indoleamine 2,3-dioxygenase 1 is required for comorbid depression-like behavior but does not contribute to neuropathic pain in mice.
Brain. Behav. Immun. 46 , 147-53, (2015) Chronic pain frequently co-occurs with major depressive disorder but the mechanisms are poorly understood. We investigated the contribution of indoleamine 2,3-dioxygenase-1 (IDO1), a rate-limiting enzyme in the conversion of tryptophan to neurotoxic metabolit... |
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Extending an in vitro panel for estrogenicity testing: the added value of bioassays for measuring antiandrogenic activities and effects on steroidogenesis.
Toxicol. Sci. 141(1) , 78-89, (2014) In the present study, a previously established integrated testing strategy (ITS) for in vitro estrogenicity testing was extended with additional in vitro assays in order to broaden its sensitivity to different modes of action resulting in apparent estrogenici... |
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Detection of 500-nucleotide DNA by laser desorption mass spectrometry.
Rapid Commun. Mass Spectrom. 8 , 727-730, (1994) We report the first detection of DNA segments as large as 500 nucleotides by matrix-assisted laser desorption/ionization (MALDI) mass spectrometry, using picolinic acid and 3-hydroxypicolinic acid mixtures as desorption matrices. The successful detection of 5... |