(S)-3-Hydroxybutanoic acid
(S)-3-Hydroxybutanoic acid structure
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Common Name | (S)-3-Hydroxybutanoic acid | ||
|---|---|---|---|---|
| CAS Number | 6168-83-8 | Molecular Weight | 104.10500 | |
| Density | 1.195 g/cm3 | Boiling Point | 269.2ºC at 760 mmHg | |
| Molecular Formula | C4H8O3 | Melting Point | 45-48ºC | |
| MSDS | Chinese USA | Flash Point | 121ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Thermophilic Coenzyme B12-Dependent Acyl Coenzyme A (CoA) Mutase from Kyrpidia tusciae DSM 2912 Preferentially Catalyzes Isomerization of (R)-3-Hydroxybutyryl-CoA and 2-Hydroxyisobutyryl-CoA.
Appl. Environ. Microbiol. 81 , 4564-72, (2015) The recent discovery of a coenzyme B12-dependent acyl-coenzyme A (acyl-CoA) mutase isomerizing 3-hydroxybutyryl- and 2-hydroxyisobutyryl-CoA in the mesophilic bacterium Aquincola tertiaricarbonis L108 (N. Yaneva, J. Schuster, F. Schäfer, V. Lede, D. Przybylsk... |
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Human brain beta-hydroxybutyrate and lactate increase in fasting-induced ketosis.
J. Cereb. Blood Flow Metab. 20(10) , 1502-7, (2000) Ketones are known to constitute an important fraction of fuel for consumption by the brain, with brain ketone content generally thought to be low. However, the recent observation of 1-mmol/L levels of brain beta-hydroxybutyrate (BHB) in children on the ketoge... |
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Contribution of 3-hydroxyisobutyrate to the measurement of 3-hydroxybutyrate in human plasma: comparison of enzymatic and gas-liquid chromatography-mass spectrometry assays in normal and in diabetic subjects.
J. Lipid Res. 30(11) , 1811-7, (1989) In this study we employed a capillary gas-liquid chromatographic-mass spectrometric (GLC-MS) method to measure the plasma concentrations of 3-hydroxybutyrate (3-OHB) and 3-hydroxyisobutyrate (3-OHIB) in overnight fasted diabetic subjects and in normal subject... |
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Oral beta-hydroxybutyrate supplementation in two patients with hyperinsulinemic hypoglycemia: monitoring of beta-hydroxybutyrate levels in blood and cerebrospinal fluid, and in the brain by in vivo magnetic resonance spectroscopy.
Pediatr. Res. 52(2) , 301-6, (2002) In persistent hyperinsulinemic hypoglycemia of infancy, ketone body concentrations are abnormally low at times of hypoglycemia, depriving the brain of its most important alternative fuel. The neuroprotective effect of endogenous ketone bodies is evidenced by ... |
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Urinary and plasma organic acids and amino acids in chronic fatigue syndrome.
Clin. Chim. Acta 361(1-2) , 150-8, (2005) Previous work by others have suggested the occurrence of one or more chemical or metabolic 'markers' for ME/CFS including specific amino acids and organic acids and a number of unidentified compounds (CFSUM1, CFSUM2). We have shown elsewhere that CFSUM1 is pa... |
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Measurement of beta-hydroxybutyrate in acute hyperketonemia in human brain.
J. Neurochem. 79(3) , 539-44, (2001) We report the measurement of D-beta-hydroxybutyrate (BHB) in the brains of six normal adult subjects during acute infusions of BHB. We used high field in vivo (1)H magnetic resonance (MR) spectroscopy in the occipital lobe in conjunction with an acute infusio... |
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Structural variation governs substrate specificity for organic anion transporter (OAT) homologs. Potential remote sensing by OAT family members.
J. Biol. Chem. 282 , 23841-53, (2007) Organic anion transporters (OATs, SLC22) interact with a remarkably diverse array of endogenous and exogenous organic anions. However, little is known about the structural features that determine their substrate selectivity. We examined the substrate binding ... |
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Organic acids in the second morning urine in a healthy Swiss paediatric population.
Clin. Chem. Lab Med. 41(12) , 1642-58, (2003) Organic acid analysis is used for the early detection/ exclusion and for the follow-up of inherited disorders of amino acid and organic acid metabolism. Urinary organic acid concentrations in 417 healthy Caucasian children (1 day to 17 years of age) were dete... |
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Elucidation of common pharmacophores from analysis of targeted metabolites transported by the multispecific drug transporter—Organic anion transporter1 (Oat1)
Bioorg. Med. Chem. 19 , 3320-40, (2011) Organic anion transporter 1 (Oat1), first identified as NKT, is a multispecific transporter responsible for the handling of drugs and toxins in the kidney and choroid plexus, but its normal physiological role appears to be in small molecule metabolite regulat... |
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Metabolic changes in the lower esophageal sphincter influencing the result of anti-reflux surgical interventions in chronic gastroesophageal reflux disease.
World J. Gastroenterol. 11(11) , 1623-8, (2005) With the availability of a minimally invasive approach, anti-reflux surgery has recently experienced a renaissance as a cost-effective alternative to life-long medical treatment in patients with gastroesophageal reflux disease (GERD). We are not aware of the ... |