Tropolone
Tropolone structure
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Common Name | Tropolone | ||
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| CAS Number | 533-75-5 | Molecular Weight | 122.121 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 290.1±33.0 °C at 760 mmHg | |
| Molecular Formula | C7H6O2 | Melting Point | 50-52 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 122.0±18.0 °C | |
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Identifying chelators for metalloprotein inhibitors using a fragment-based approach.
J. Med. Chem. 54 , 591-602, (2011) Fragment-based lead design (FBLD) has been used to identify new metal-binding groups for metalloenzyme inhibitors. When screened at 1 mM, a chelator fragment library (CFL-1.1) of 96 compounds produced hit rates ranging from 29% to 43% for five matrix metallop... |
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Determination of hinokitiol in skin lotion by high-performance liquid chromatography-ultraviolet detection after precolumn derivatization with 4-fluoro-7-nitro-2,1,3-benzoxadiazole.
J. Cosmet. Sci. 64(5) , 381-9, (2013) Hinokitiol, a potent, broad-spectrum antibacterial agent, is a component of various personal care products. In this study, the concentration of hinokitiol in skin lotion was analyzed by means of high-performance liquid chromatography-ultraviolet detection (38... |
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The furan route to tropolones: probing the antiproliferative effects of β-thujaplicin analogs.
Org. Biomol. Chem. 10(43) , 8597-604, (2012) A direct route to analogs of the naturally occurring tropolone β-thujaplicin has been developed in just four steps from furan. Using this method, a series of derivatives were synthesized and evaluated. Several of these compounds demonstrated very high levels ... |
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Preventive effects of β-thujaplicin against UVB-induced MMP-1 and MMP-3 mRNA expressions in skin fibroblasts.
Am. J. Chin. Med. 40(2) , 387-98, (2012) Solar UV radiation damages human skin by affecting skin tone and resiliency and leads to premature aging (photoaging). The skin damage is caused by the activation of the AP-1 transcription factor, which increases matrix metalloproteinase (MMP) expression and ... |
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Synthesis of tropolone derivatives and evaluation of their in vitro neuroprotective activity.
Eur. J. Med. Chem. 45 , 1107-12, (2010) beta-Thujaplicin (hinokitiol or 2-hydroxy-4-isopropyl-2,4,6-cycloheptatrien-1-one), a natural tropolone, shows numerous activities while its synthetic analogues were found to exhibit anticancer and anti-ischemic activity. However, the ability of tropolone der... |
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Effects of a combination of hinokitiol (β-thujaplicin) and an organic acid mixture on ruminal fermentation in heifers fed a high-grain diet.
Anim. Sci. J. 83(1) , 36-42, (2012) This study evaluated the effects of hinokitiol (a natural antibacterial compound extracted from Thujopsis dolabrata var. hondai) and an organic acid mixture (citrate content 50%) on ruminal fermentation. Antibacterial properties were examined by measuring min... |
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Stress-related activities induced by predator odor may become indistinguishable by hinokitiol odor.
Neuroreport 23(18) , 1071-6, (2012) Predator odors, such as 2,5-dihydro-2,4,5-trimethylthiazoline (TMT), induce a stress-like behavior in some rodents, and there is activation of a complex mix of brain regions including the anterior piriform cortex (APC) and the bed nucleus of stria terminalis ... |
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In vitro and in vivo anti-plasmodial activity of essential oils, including hinokitiol.
Southeast Asian J. Trop. Med. Public Health 43(2) , 270-9, (2012) Abstract. The anti-plasmodial activity of 47 essential oils and 10 of their constituents were screened for in vitro activity against Plasmodium falciparum. Five of these essential oils (sandalwood, caraway, monarda, nutmeg, and Thujopsis dolabrata var. hondai... |
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Hinokitiol inhibits platelet activation ex vivo and thrombus formation in vivo
Biochem. Pharmacol. 85(10) , 1478-85, (2013) Hinokitiol is a tropolone-related bioactive compound that has been used in hair tonics, cosmetics, and food as an antimicrobial agent. Recently, hinokitiol has attracted considerable interest because of its anticancer activities. Platelet activation plays a c... |
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In vitro and in vivo therapeutics of β-thujaplicin on LPS-induced inflammation in macrophages and septic shock in mice.
Int. J. Immunopathol. Pharmacol. 25(1) , 39-48, (2012) β-thujaplicin, an active constituent from Chamaecyparis obtusa, has been shown to have acaricidal and antimicrobial effects. Very few studies have focused on the potential of the anti-inflammatory effect of β-thujaplicin. Moreover, its capability of inhibitin... |