Ribavirin
Ribavirin structure
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Common Name | Ribavirin | ||
|---|---|---|---|---|
| CAS Number | 36791-04-5 | Molecular Weight | 244.205 | |
| Density | 2.1±0.1 g/cm3 | Boiling Point | 639.8±65.0 °C at 760 mmHg | |
| Molecular Formula | C8H12N4O5 | Melting Point | 174-176°C | |
| MSDS | Chinese USA | Flash Point | 340.7±34.3 °C | |
| Symbol |
GHS08 |
Signal Word | Danger | |
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Genetic and pharmacologic inhibition of eIF4E reduces breast cancer cell migration, invasion, and metastasis.
Cancer Res. 75(6) , 1102-12, (2015) The translation initiation factor eIF4E is an oncogene that is commonly overexpressed in primary breast cancers and metastases. In this article, we report that a pharmacologic inhibitor of eIF4E function, ribavirin, safely and potently suppresses breast tumor... |
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An integrated biological approach to guide the development of metal-chelating inhibitors of influenza virus PA endonuclease.
Mol. Pharmacol. 87(2) , 323-37, (2015) The influenza virus PA endonuclease, which cleaves capped cellular pre-mRNAs to prime viral mRNA synthesis, is a promising target for novel anti-influenza virus therapeutics. The catalytic center of this enzyme resides in the N-terminal part of PA (PA-Nter) a... |
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Antiviral and antitumor activities of the lectin extracted from Aspidistra elatior.
Z. Naturforsch., C, J. Biosci. 70 , 7-13, (2015) Lectins, a group of highly diverse proteins of non-immune origin and are ubiquitously distributed in plants, animals and fungi, have multiple significant biological functions, such as anti-fungal, anti-viral and, most notably, anti-tumor activities. A lectin ... |
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Virus uncoating is required for apoptosis induction in cultured mammalian cells infected with African horse sickness virus.
J. Gen. Virol. 96 , 1811-20, (2015) Infection of cultured mammalian cells with African horse sickness virus (AHSV) is known to induce cell death. To date, the trigger(s) of this response, the apoptotic pathways activated during AHSV infection and the functional consequences of apoptosis on the ... |
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Identification of AP80978, a novel small-molecule inhibitor of hepatitis C virus replication that targets NS4B.
Antimicrob. Agents Chemother. 58(6) , 3399-410, (2014) A small-molecule inhibitor of hepatitis C virus (HCV) designated AP89652 was identified by screening a compound library with an HCV genotype 1b subgenomic replicon assay. AP89652 contains two chiral centers, and testing of two syn enantiomers revealed that ac... |
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Measurement of intracellular ribavirin mono-, di- and triphosphate using solid phase extraction and LC-MS/MS quantification.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 978-979 , 163-72, (2015) Ribavirin (RBV) is a nucleoside analog used to treat a variety of DNA and RNA viruses. RBV undergoes intracellular phosphorylation to a mono- (MP), di- (DP), and triphosphate (TP). The phosphorylated forms have been associated with the mechanisms of antiviral... |
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Modeling viral kinetics and treatment outcome during alisporivir interferon-free treatment in hepatitis C virus genotype 2 and 3 patients.
Hepatology 59(5) , 1706-14, (2014) Alisporivir (ALV) is a cyclophilin inhibitor with pan-genotypic activity against hepatitis C virus (HCV). Here, we characterize the viral kinetics observed in 249 patients infected with HCV genotypes 2 or 3 and treated for 6 weeks with different doses of ALV ... |
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The correlation between pretreatment cytokine expression patterns in peripheral blood mononuclear cells with chronic hepatitis C outcome.
BMC Infect. Dis. 15 , 556, (2015) Cytokine response against hepatitis C virus (HCV) is likely to determine the natural course of infection as well as the outcome of antiviral treatment. However, the role of particular cytokines remains unclear. The current study analyzed activation of cytokin... |
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Effective lethal mutagenesis of influenza virus by three nucleoside analogs.
J. Virol. 89(7) , 3584-97, (2015) Lethal mutagenesis is a broad-spectrum antiviral strategy that exploits the high mutation rate and low mutational tolerance of many RNA viruses. This approach uses mutagenic drugs to increase viral mutation rates and burden viral populations with mutations th... |
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Development of biodegradable nanoparticles for liver-specific ribavirin delivery.
J. Pharm. Sci. 103(12) , 4005-11, (2014) Ribavirin is an antiviral drug used for the treatment of chronic hepatitis C. However, ribavirin induces severe side effects such as hemolytic anemia. In this study, we prepared biodegradable nanoparticles as ribavirin carriers to modulate the pharmacokinetic... |