Chlorothiazide
Chlorothiazide structure
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Common Name | Chlorothiazide | ||
|---|---|---|---|---|
| CAS Number | 58-94-6 | Molecular Weight | 295.723 | |
| Density | 2.0±0.1 g/cm3 | Boiling Point | 608.8±65.0 °C at 760 mmHg | |
| Molecular Formula | C7H6ClN3O4S2 | Melting Point | 342-343°C | |
| MSDS | Chinese USA | Flash Point | 322.0±34.3 °C | |
| Symbol |
GHS08 |
Signal Word | Danger | |
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Fast targeted analysis of 132 acidic and neutral drugs and poisons in whole blood using LC-MS/MS.
Forensic Sci. Int. 243 , 35-43, (2014) The aim of this study was to develop an LC-MS/MS based screening technique that covers a broad range of acidic and neutral drugs and poisons by combining a small sample volume and efficient extraction technique with simple automated data processing. After pro... |
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Variation in the use of diuretic therapy for infants with bronchopulmonary dysplasia.
Pediatrics 131(4) , 716-23, (2013) To determine (1) between-hospital variation in diuretic use for infants with bronchopulmonary dysplasia (BPD), including hospital-specific treatment frequency, treatment duration, and percentage of infants receiving short (≤5 consecutive days) versus longer (... |
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Detection of urinary markers for thiazide diuretics after oral administration of hydrochlorothiazide and altizide-relevance to doping control analysis
J. Chromatogr. A. 1216(12) , 2466-73, (2009) In sports, thiazide diuretics are used to flush out previously taken prohibited substances with forced diuresis and in sports where weight classes are involved to achieve acute weight loss. Thiazide diuretics include compounds which are very unstable and hydr... |
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ABCG2 modulates chlorothiazide permeability--in vitro-characterization of its interactions.
Drug Metab. Pharmacokinet. 27(3) , 349-53, (2012) We are showing that chlorothiazide, a diuretic, is an ABCG2 substrate. It is a Biopharmaceutics Classification System/Biopharmaceutics Drug Distribution and Classification System (BCS/BDDCS) Class IV drug with low bioavailability. Therefore, we tested if chlo... |
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Management of central diabetes insipidus in infancy with low renal solute load formula and chlorothiazide.
Curr. Opin. Pediatr. 12(4) , 405-11, (2000)
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Diuretics for respiratory distress syndrome in preterm infants.
Cochrane Database Syst. Rev. (1) , CD001454, (2008) Lung edema may complicate respiratory distress syndrome (RDS) in preterm infants.The aim of this review was to assess the risks and benefits of diuretic administration in preterm infants with RDS.The standard search method of the Cochrane Neonatal Review Grou... |
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Hyperinsulinism in tyrosinaemia type I.
J. Inherit. Metab. Dis. 28(2) , 131-5, (2005) Tyrosinaemia type I (TT I) (McKusick 276700) is a heterogeneous disorder with a broad spectrum of clinical phenotypes. Although histological abnormalities of the pancreas are well recognized, there are only incidental reports of pancreatic dysfunction manifes... |
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GPR35 is a target of the loop diuretic drugs bumetanide and furosemide.
Pharmacology 89(1-2) , 13-7, (2012) We report that the loop diuretic drugs bumetanide and furosemide used in the treatment of hypertension are GPR35 agonists. We utilized calcium flux, inositol phosphate accumulation, and dynamic redistribution assays to examine the pharmacology of these compou... |
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Preparation and characterization of novel semi-interpenetrating polymer network hydrogel microspheres of chitosan and hydroxypropyl cellulose for controlled release of chlorothiazide.
J. Microencapsul. 26(1) , 27-36, (2009) Novel semi-interpenetrating polymer network (IPN) hydrogel microspheres of chitosan (CS) and hydroxypropyl cellulose (HPC) were prepared by emulsion-cross-linking method using glutaraldehyde (GA) as a cross-linker. Chlorothiazide (CT), a diuretic and anti-hyp... |
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Releasing the flood waters: diuril and the reshaping of hypertension.
Bull. Hist. Med. 79(4) , 749-94, (2005) This article narrates the development and promotion in the 1950s and 1960s of Merck, Sharp & Dohme's Diuril (chlorothiazide), an antihypertensive drug, which played a significant role in the redefinition of high blood pressure as a widespread target for chron... |