Propranolol hydrochloride
Propranolol hydrochloride structure
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Common Name | Propranolol hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 318-98-9 | Molecular Weight | 332.265 | |
| Density | N/A | Boiling Point | 434.9ºC at 760mmHg | |
| Molecular Formula | C16H22ClNO2 | Melting Point | 163-165 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 216.8ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Utility of cerebrospinal fluid drug concentration as a surrogate for unbound brain concentration in nonhuman primates.
Drug Metab. Pharmacokinet. 29(5) , 419-26, (2014) In central nervous system drug discovery, cerebrospinal fluid (CSF) drug concentration (C(CSF)) has been widely used as a surrogate for unbound brain concentrations (C(u,brain)). However, previous rodent studies demonstrated that when drugs undergo active eff... |
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An enhanced droplet-based liquid microjunction surface sampling system coupled with HPLC-ESI-MS/MS for spatially resolved analysis.
Anal. Bioanal. Chem 407(8) , 2117-25, (2015) Droplet-based liquid microjunction surface sampling coupled with high-performance liquid chromatography (HPLC)-electrospray ionization (ESI)-tandem mass spectrometry (MS/MS) for spatially resolved analysis provides the possibility of effective analysis of com... |
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A rapid method for determination of 22 selected drugs in human urine by UHPLC/MS/MS for clinical application.
J. AOAC Int. 97(6) , 1526-37, (2015) A rapid and sensitive ultra-HPLC/MSIMS (UHPLC/MSIMS) assay method for the simultaneous determination in human urine of 22 drugs belonging to different pharmaceutical groups was developed. The drugs were extracted from urine samples and then separated on a Zor... |
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Enantiomeric fraction evaluation of pharmaceuticals in environmental matrices by liquid chromatography-tandem mass spectrometry.
J. Chromatogr. A. 1363 , 226-235, (2014) The interest for environmental fate assessment of chiral pharmaceuticals is increasing and enantioselective analytical methods are mandatory. This study presents an enantioselective analytical method for the quantification of seven pairs of enantiomers of pha... |
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Neurotransmitter-mediated anxiogenic action of PACAP-38 in rats.
Behav. Brain Res. 281 , 333-8, (2015) The action of PACAP-38 was studied by measuring the anxiogenic-anxiolytic behavior of rats in an elevated plus maze. PACAP-38 was administered into the lateral brain ventricle and the behavior of the animals was measured 3h later. The possible involvement of ... |
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Genetically engineered SCN5A mutant pig hearts exhibit conduction defects and arrhythmias.
J. Clin. Invest. 125(1) , 403-12, (2015) SCN5A encodes the α subunit of the major cardiac sodium channel Na(V)1.5. Mutations in SCN5A are associated with conduction disease and ventricular fibrillation (VF); however, the mechanisms that link loss of sodium channel function to arrhythmic instability ... |
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The effect of hyperpolarization-activated cyclic nucleotide-gated ion channel inhibitors on the vagal control of guinea pig airway smooth muscle tone.
Br. J. Pharmacol. 171(15) , 3633-50, (2014) Subtypes of the hyperpolarization-activated cyclic nucleotide-gated (HCN) family of cation channels are widely expressed on nerves and smooth muscle cells in many organ systems, where they serve to regulate membrane excitability. Here we have assessed whether... |
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The antipsychotic amisulpride: ultrastructural evidence of its secretory activity in salivary glands.
Oral Dis. 20(8) , 796-802, (2014) Amisulpride is reported to inhibit clozapine-induced sialorrhea. Preclinically, clozapine evokes muscarinic-M1-type-mediated secretion that, however, amisulpride does not reduce. Instead, amisulpride, without causing any overt secretion per se, enhances both ... |
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A primary fish gill cell culture model to assess pharmaceutical uptake and efflux: evidence for passive and facilitated transport.
Aquat. Toxicol. 159 , 127-37, (2015) The gill is the principle site of xenobiotic transfer to and from the aqueous environment. To replace, refine or reduce (3Rs) the large numbers of fish used in in vivo uptake studies an effective in vitro screen is required that mimics the function of the tel... |
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Simultaneous determination of tramadol and O-desmethyltramadol in human plasma using HPLC-DAD.
J. Chromatogr. Sci. 52(10) , 1186-92, (2014) A sensitive and accurate method for the extraction and quantification of tramadol (T) and its active metabolite, O-desmethyltramadol (ODT) in human plasma with high-performance liquid chromatography-diode array detection was developed and validated. The analy... |