Urethane
Urethane structure
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Common Name | Urethane | ||
|---|---|---|---|---|
| CAS Number | 51-79-6 | Molecular Weight | 89.093 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 105.7±23.0 °C at 760 mmHg | |
| Molecular Formula | C3H7NO2 | Melting Point | 48-50 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 17.7±22.6 °C | |
| Symbol |
GHS07, GHS08 |
Signal Word | Danger | |
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Mechanistic basis of altered morphine disposition in nonalcoholic steatohepatitis.
J. Pharmacol. Exp. Ther. 352(3) , 462-70, (2015) Morphine is metabolized in humans to morphine-3-glucuronide (M3G) and the pharmacologically active morphine-6-glucuronide (M6G). The hepatobiliary disposition of both metabolites relies upon multidrug resistance-associated proteins Mrp3 and Mrp2, located on t... |
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Loss of presenilin 2 is associated with increased iPLA2 activity and lung tumor development.
Oncogene 33(44) , 5193-200, (2014) Presenilins are the enzymatic components of γ-secretase complex that cleaves amyloid precursor protein, Notch and β-catenin, which has critical roles in the development of Alzheimer's disease and cancer cell growth. Therefore, in the present study, we studied... |
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The Ca²⁺-calmodulin-Ca²⁺/calmodulin-dependent protein kinase II signaling pathway is involved in oxidative stress-induced mitochondrial permeability transition and apoptosis in isolated rat hepatocytes.
Arch. Toxicol. 88(9) , 1695-709, (2014) Oxidative stress (OS) is a common event in most hepatopathies, leading to mitochondrial permeability transition pore (MPTP) formation and further exacerbation of both OS from mitochondrial origin and cell death. Intracellular Ca²⁺ increase plays a permissive ... |
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Chronic ethanol consumption induces erectile dysfunction: Role of oxidative stress.
Life Sci. 141 , 44-53, (2015) Investigate the effects of chronic ethanol consumption on erectile function and on the corpus cavernosum (CC) reactivity to endothelin-1 (ET-1).Male Wistar rats were treated with ethanol (20% v/v) for six weeks.Ethanol-treated rats showed impaired erectile fu... |
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Characterization of human lymphoblastoid cell lines as a novel in vitro test system to predict the immunotoxicity of xenobiotics.
Toxicol. Lett. 233(1) , 8-15, (2015) Evaluating immunomodulatory effects of xenobiotics is an important component of the toxicity studies. Herein we report on the establishment of a novel invitro test system for the immunotoxicity screening of xenobiotics based on human lymphoblastoid cell lines... |
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Adenosine monophosphate is elevated in the bronchoalveolar lavage fluid of mice with acute respiratory toxicity induced by nanoparticles with high surface hydrophobicity.
Nanotoxicology 9(1) , 106-15, (2015) Inhaled nanomaterials present a challenge to traditional methods and understanding of respiratory toxicology. In this study, a non-targeted metabolomics approach was used to investigate relationships between nanoparticle hydrophobicity, inflammatory outcomes ... |
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Complementary expression and phosphorylation of Cx46 and Cx50 during development and following gene deletion in mouse and in normal and orchitic mink testes.
Am. J. Physiol. Regul. Integr. Comp. Physiol. 309 , R255-76, (2015) Gap junction-mediated communication helps synchronize interconnected Sertoli cell activities. Besides, coordination of germ cell and Sertoli cell activities depends on gap junction-mediated Sertoli cell-germ cell communication. This report assesses mechanisms... |
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The effect of hyperpolarization-activated cyclic nucleotide-gated ion channel inhibitors on the vagal control of guinea pig airway smooth muscle tone.
Br. J. Pharmacol. 171(15) , 3633-50, (2014) Subtypes of the hyperpolarization-activated cyclic nucleotide-gated (HCN) family of cation channels are widely expressed on nerves and smooth muscle cells in many organ systems, where they serve to regulate membrane excitability. Here we have assessed whether... |
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Quorum Sensing Peptides Selectively Penetrate the Blood-Brain Barrier.
PLoS ONE 10 , e0142071, (2015) Bacteria communicate with each other by the use of signaling molecules, a process called 'quorum sensing'. One group of quorum sensing molecules includes the oligopeptides, which are mainly produced by Gram-positive bacteria. Recently, these quorum sensing pe... |
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Effects of prolonged neuronal nitric oxide synthase inhibition on the development and expression of L-DOPA-induced dyskinesia in 6-OHDA-lesioned rats.
Neuropharmacology 89 , 87-99, (2014) It is well known that nitric oxide (NO) interacts with dopamine (DA) within the striatal circuitry. The anti-dyskinetic properties of NO synthase (NOS) inhibitors demonstrate the importance of NO in L-3,4-dihydroxyphenylalanine (L-DOPA)-induced dyskinesia (LI... |