Quinalizarin
Quinalizarin structure
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Common Name | Quinalizarin | ||
|---|---|---|---|---|
| CAS Number | 81-61-8 | Molecular Weight | 272.210 | |
| Density | 1.8±0.1 g/cm3 | Boiling Point | 517.1±45.0 °C at 760 mmHg | |
| Molecular Formula | C14H8O6 | Melting Point | 99 °C | |
| MSDS | Chinese USA | Flash Point | 280.6±25.2 °C | |
| Symbol |
GHS07, GHS09 |
Signal Word | Warning | |
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Protein kinase CK2 potentiates translation efficiency by phosphorylating eIF3j at Ser127.
Biochim. Biophys. Acta 1853 , 1693-701, (2015) In eukaryotic protein synthesis the translation initiation factor 3 (eIF3) is a key player in the recruitment and assembly of the translation initiation machinery. Mammalian eIF3 consists of 13 subunits, including the loosely associated eIF3j subunit that pla... |
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A complex signaling network involving protein kinase CK2 is required for hepatitis C virus core protein-mediated modulation of the iron-regulatory hepcidin gene expression.
Cell. Mol. Life Sci. 71(21) , 4243-58, (2014) Hepatitis C virus (HCV) infection is associated with hepatic iron overload and elevated serum iron that correlate to poor antiviral responses. Hepcidin (HAMP), a 25-aa cysteine-rich liver-specific peptide, controls iron homeostasis. Its expression is up-regul... |
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Quinalizarin enhances radiosensitivity of nasopharyngeal carcinoma cells partially by suppressing SHP-1 expression.
Int. J. Oncol. 48 , 1073-84, (2016) The purpose of this study was to investigate the influence of quinalizarin on the radiosensitivity of nasopharyngeal carcinoma (NPC) cells and the relevant underlying mechanisms. Human NPC cell lines CNE-1, CNE-2 and 5-8F were treated with quinalizarin and th... |
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Identification of Hydroxyanthraquinones as Novel Inhibitors of Hepatitis C Virus NS3 Helicase.
Int. J. Mol. Sci. 16 , 18439-53, (2015) Hepatitis C virus (HCV) is an important etiological agent of severe liver diseases, including cirrhosis and hepatocellular carcinoma. The HCV genome encodes nonstructural protein 3 (NS3) helicase, which is a potential anti-HCV drug target because its enzymati... |
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Transcriptional Regulation of JARID1B/KDM5B Histone Demethylase by Ikaros, Histone Deacetylase 1 (HDAC1), and Casein Kinase 2 (CK2) in B-cell Acute Lymphoblastic Leukemia.
J. Biol. Chem. 291 , 4004-18, (2016) Impaired function of the Ikaros (IKZF1) protein is associated with the development of high-risk B-cell precursor acute lymphoblastic leukemia (B-ALL). The mechanisms of Ikaros tumor suppressor activity in leukemia are unknown. Ikaros binds to the upstream reg... |
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Cell-permeable dual inhibitors of protein kinases CK2 and PIM-1: structural features and pharmacological potential.
Cell. Mol. Life Sci. 71(16) , 3173-85, (2014) It has been proposed that dual inhibitors of protein kinases CK2 and PIM-1 are tools particularly valuable to induce apoptosis of cancer cells, a property, however, implying cell permeability, which is lacking in the case of selective CK2/PIM-1 inhibitors dev... |
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Quinalizarin, a specific CK2 inhibitor, reduces cell viability and suppresses migration and accelerates apoptosis in different human lung cancer cell lines.
Indian J. Cancer 52 Suppl 2 , e119-24, (2016) Protein kinase CK2 is widely expressed in eukaryotic cells, and plays an important role in cell proliferation, migration, apoptosis, etc. The aim of the current study is to explore how Quinalizarin, a specific CK2 inhibitor, affects the cell proliferation, mi... |
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Protein kinase CK2 regulates metal toxicity in neuronal cells.
Metallomics 8 , 82-90, (2016) Protein kinase CK2 is a pleiotropic tetrameric enzyme, regulating numerous biological processes from cell proliferation to stress response. This study demonstrates for the first time that CK2 is involved in the regulation of metal uptake and toxicity in neuro... |