5719-85-7

5719-85-7 structure

Name: 4 hydroxy tolbutamide
Chemical Name: 4-hydroxytolbutamide
CAS Number: 5719-85-7
Molecular Formula: C₁₂H₁₈N₂O₄S
Molecular Weight: 286.347
Catalog: analytical chemistry Standard standard material
Create Date: 2018-08-07 01:16:07
Modify Date: 2024-01-02 17:43:39
4-Hydroxytolbutamide (Hydroxytolbutamide) is a metabolite of Tolbutamide. 4-Hydroxytolbutamide is metabolized by CYP2C8 and CYP2C9. Tolbutamide is a first generation potassium channel blocker and a sulfonylurea oral antidiabetic[1][2].

Name	4-hydroxytolbutamide
Synonyms	1-Butyl-3-(4-hydroxymethylphenyl)sulfonylurea Benzenesulfonamide, N-[(butylamino)carbonyl]-4-(hydroxymethyl)- hydroxymethyl-TB 4-OH-tolbutamide Methylhydroxytolbutamide hydroxymethyltolbutamide Hydroxytolbutamide 4-Hydroxytolbutamide 4 hydroxy tolbutamide N-(Butylcarbamoyl)-4-(hydroxymethyl)benzenesulfonamide [14C]-Hydroxytolbutamide N-(Butylaminocarbonyl)-4-hydroxymethylbenzenesulfonamide 1-butyl-3-[4-(hydroxymethyl)phenyl]sulfonylurea

Description	4-Hydroxytolbutamide (Hydroxytolbutamide) is a metabolite of Tolbutamide. 4-Hydroxytolbutamide is metabolized by CYP2C8 and CYP2C9. Tolbutamide is a first generation potassium channel blocker and a sulfonylurea oral antidiabetic[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Metabolic Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
Target	Potassium channel
References	[1]. Hansen LL, et al. Quantitative determination of tolbutamide and its metabolites in human plasma and urine by high-performance liquid chromatography and UV detection. Ther Drug Monit. 1999 Dec;21(6):664-71. [2]. Yuan R, et al. Evaluation of cytochrome P450 probe substrates commonly used by the pharmaceutical industry to study in vitro drug interactions. Drug Metab Dispos. 2002 Dec;30(12):1311-9.

Symbol	GHS02, GHS07
Signal Word	Danger
Hazard Statements	H225-H302 + H312 + H332-H319
Precautionary Statements	P210-P261-P302 + P352 + P312-P304 + P340 + P312-P337 + P313-P403 + P235
Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	F,Xn
Risk Phrases	11-20/21/22-36
Safety Phrases	16-36/37-24/25
RIDADR	UN 1648 3 / PGII
WGK Germany	3
HS Code	29350090