Chinese Chemical Letters

Silica gel catalyzed α-bromination of ketones using N-bromosuccinimide: An easy and rapid method

BM Reddy, VVR Kumar, NCG Reddy, SM Rao

Index: Mohan Reddy, Bodireddy; Venkata Ramana Kumar, Velpula; Chinna Gangi Reddy, Nallagondu; Mahender Rao, Siripragada Chinese Chemical Letters, 2014 , vol. 25, # 1 p. 179 - 182

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Citation Number: 10

Abstract

Abstract An easy and rapid method for the α-bromination of ketones using N- bromosuccinimide (NBS) catalyzed by silica gel in methanol under reflux conditions was developed. The expected products were formed in excellent isolated yields within a short period of time (5–20 min). Major advantages of the present procedure include use of inexpensive and readily available catalyst, exclusion of pre-and post-chemical treatment ...

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Acetophenone Structure

98-86-2

Acetophenone

~0%

DIBROMOACETOPHENONE Structure

13665-04-8

DIBROMOACETOPHENONE

m-Bromoacetophenone Structure

2142-63-4

m-Bromoacetophenone

2-Bromoacetophenone Structure

70-11-1

2-Bromoacetophenone

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1-(4-Chlorophenyl)ethanone Structure

99-91-2

1-(4-Chlorophen...

~0%

2,2-Dibromo-1-(4-chlorophenyl)ethanone Structure

13651-12-2

2,2-Dibromo-1-(...

2-Bromo-4'-chloroacetophenone Structure

536-38-9

2-Bromo-4'-chlo...

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4-Nitroacetophenone Structure

100-19-6

4-Nitroacetophenone

~0%

2,2-DIBROMO-1-(4-NITROPHENYL)ETHAN-1-ONE Structure

21566-36-9

2,2-DIBROMO-1-(...

p-nitrophenacyl bromide Structure

99-81-0

p-nitrophenacyl...

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P-ETHYLACETOPHENONE Structure

937-30-4

P-ETHYLACETOPHENONE

~89%

2-bromo-1-(4-ethylphenyl)ethanone Structure

2632-14-6

2-bromo-1-(4-et...

α,α-Dibrom-4-ethylacetophenon Structure

41036-98-0

α,α-Dibrom-4-et...

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2-Methylacetophenone Structure

577-16-2

2-Methylacetophenone

~0%

2,2-dibromo-1-(2-methylphenyl)ethanone Structure

65523-96-8

2,2-dibromo-1-(...

2-Bromo-1-(2-methylphenyl)ethanone Structure

51012-65-8

2-Bromo-1-(2-me...

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1-(4-Bromophenyl)ethanone Structure

99-90-1

1-(4-Bromopheny...

~84%

Ethanone,2,2-dibromo-1-(4-bromophenyl) Structure

13195-79-4

Ethanone,2,2-di...

2,4′-dibromoacetophenone Structure

99-73-0

2,4′-dibromoace...

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1-(4-Chlorophenyl)ethanone Structure

99-91-2

1-(4-Chlorophen...

~90%

2,2-Dibromo-1-(4-chlorophenyl)ethanone Structure

13651-12-2

2,2-Dibromo-1-(...

2-Bromo-4'-chloroacetophenone Structure

536-38-9

2-Bromo-4'-chlo...

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Acetophenone Structure

98-86-2

Acetophenone

~92%

DIBROMOACETOPHENONE Structure

13665-04-8

DIBROMOACETOPHENONE

2-Bromoacetophenone Structure

70-11-1

2-Bromoacetophenone

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Acetophenone Structure

98-86-2

Acetophenone

~35%

DIBROMOACETOPHENONE Structure

13665-04-8

DIBROMOACETOPHENONE

m-Bromoacetophenone Structure

2142-63-4

m-Bromoacetophenone

2-Bromoacetophenone Structure

70-11-1

2-Bromoacetophenone

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3'-Nitroacetophenone Structure

121-89-1

3'-Nitroacetophenone

~41%

2,2-dibromo-1-(3-nitrophenyl)ethanone Structure

13651-07-5

2,2-dibromo-1-(...

3-Nitrophenacylbromide Structure

2227-64-7

3-Nitrophenacyl...

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2-Acetonaphthone Structure

93-08-3

2-Acetonaphthone

~0%

2-(Dibromoacetyl)naphthalene Structure

13651-05-3

2-(Dibromoacety...

2-Bromo-1-(2-naphthyl)ethanone Structure

613-54-7

2-Bromo-1-(2-na...

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Acetanisole Structure

100-06-1

Acetanisole

~62%

α,α-dichloro-4-methoxyacetophenone Structure

13664-92-1

α,α-dichloro-4-...

PTP inhibitor 1 Structure

2632-13-5

PTP inhibitor 1

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2-Methylacetophenone Structure

577-16-2

2-Methylacetophenone

~87%

2,2-dibromo-1-(2-methylphenyl)ethanone Structure

65523-96-8

2,2-dibromo-1-(...

2-Bromo-1-(2-methylphenyl)ethanone Structure

51012-65-8

2-Bromo-1-(2-me...

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4'-Methylacetophenone Structure

122-00-9

4'-Methylacetop...

~92%

2,2-Dibromo-4'-methylacetophenone Structure

13664-98-7

2,2-Dibromo-4'-...

2-bromo-4'-methylacetophenone Structure

619-41-0

2-bromo-4'-meth...

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1'-Acetonaphthone Structure

941-98-0

1'-Acetonaphthone

~79%

Ethanone, 2,2-dibromo-1-(1-naphthalenyl) Structure

91331-09-8

Ethanone, 2,2-d...

2-BROMO-1-(NAPHTHALEN-1-YL)ETHANONE Structure

13686-51-6

2-BROMO-1-(NAPH...

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2-Acetonaphthone Structure

93-08-3

2-Acetonaphthone

~85%

2-(Dibromoacetyl)naphthalene Structure

13651-05-3

2-(Dibromoacety...

2-Bromo-1-(2-naphthyl)ethanone Structure

613-54-7

2-Bromo-1-(2-na...

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Cyclohexanone Structure

108-94-1

Cyclohexanone

~0%

2-bromo-cyclo-hexanone Structure

1056477-06-5

2-bromo-cyclo-h...

2,2-dibromocyclohexan-1-one Structure

28867-02-9

2,2-dibromocycl...

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3'-Chloroacetophenone Structure

99-02-5

3'-Chloroacetop...

~80%

2,2-dibromo-1-(3-chlorophenyl)ethanone Structure

25847-29-4

2,2-dibromo-1-(...

3-Chlorophenacyl Bromide Structure

41011-01-2

3-Chlorophenacy...

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1-(4-Bromophenyl)ethanone Structure

99-90-1

1-(4-Bromopheny...

~0%

Ethanone,2,2-dibromo-1-(4-bromophenyl) Structure

13195-79-4

Ethanone,2,2-di...

2,4′-dibromoacetophenone Structure

99-73-0

2,4′-dibromoace...

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4-Nitroacetophenone Structure

100-19-6

4-Nitroacetophenone

~46%

2,2-DIBROMO-1-(4-NITROPHENYL)ETHAN-1-ONE Structure

21566-36-9

2,2-DIBROMO-1-(...

p-nitrophenacyl bromide Structure

99-81-0

p-nitrophenacyl...

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