Chinese Chemical Letters

Silica gel catalyzed α-bromination of ketones using N-bromosuccinimide: An easy and rapid method

BM Reddy, VVR Kumar, NCG Reddy, SM Rao

Index: Mohan Reddy, Bodireddy; Venkata Ramana Kumar, Velpula; Chinna Gangi Reddy, Nallagondu; Mahender Rao, Siripragada Chinese Chemical Letters, 2014 , vol. 25, # 1 p. 179 - 182

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Citation Number: 10

Abstract

Abstract An easy and rapid method for the α-bromination of ketones using N- bromosuccinimide (NBS) catalyzed by silica gel in methanol under reflux conditions was developed. The expected products were formed in excellent isolated yields within a short period of time (5–20 min). Major advantages of the present procedure include use of inexpensive and readily available catalyst, exclusion of pre-and post-chemical treatment ...

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2-Methylacetophenone

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