Microwave??Assisted Deacylation of Unactivated Amides Using Ammonium??Salt??Accelerated Transamidation

…, H Morimoto, M Zhang, T Ohshima

Index: Shimizu, Yuhei; Morimoto, Hiroyuki; Zhang, Ming; Ohshima, Takashi Angewandte Chemie - International Edition, 2012 , vol. 51, # 34 p. 8564 - 8567

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Citation Number: 31

Abstract

Amines are ubiquitous organic molecules in natural products and pharmaceuticals [1] and efficient synthesis of amines is an important topic in synthetic organic chemistry. Recent efforts to streamline organic synthesis favors the use of unprotected molecules in synthetic protocols,[2] but amine protection is still a reliable way to obtain satisfactory yields of the desired products and unprotected amines are often too reactive to avoid undesired ...

351-83-7

4'-fluoroacetanilide

~96%

~92%

~90%

~88%

~87%

~10%

~92%

~96%

~10%

~99%

~92%

~98%

~92%

~99%

~94%

~11%

~89%

~80%

~98%

~85%

~96%

~87%

~80%

~10%

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