Thiol-PEG3-acid

Modify Date: 2025-08-25 12:00:20

Thiol-PEG3-acid Structure
Thiol-PEG3-acid structure
Common Name Thiol-PEG3-acid
CAS Number 1347750-82-6 Molecular Weight 238.301
Density 1.2±0.1 g/cm3 Boiling Point 377.5±37.0 °C at 760 mmHg
Molecular Formula C9H18O5S Melting Point N/A
MSDS N/A Flash Point 182.1±26.5 °C

 Use of Thiol-PEG3-acid


Thiol-PEG3-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 3-{2-[2-(2-Sulfanylethoxy)ethoxy]ethoxy}propanoic acid
Synonym More Synonyms

 Thiol-PEG3-acid Biological Activity

Description Thiol-PEG3-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 377.5±37.0 °C at 760 mmHg
Molecular Formula C9H18O5S
Molecular Weight 238.301
Flash Point 182.1±26.5 °C
Exact Mass 238.087494
LogP -0.30
Vapour Pressure 0.0±1.8 mmHg at 25°C
Index of Refraction 1.482
InChIKey HWTXXNAQBWZFHL-UHFFFAOYSA-N
SMILES O=C(O)CCOCCOCCOCCS

 Synonyms

3-{2-[2-(2-Sulfanylethoxy)ethoxy]ethoxy}propanoic acid
MFCD25424073
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