Thiol-PEG3-acetic acid

Modify Date: 2024-01-04 08:30:59

Thiol-PEG3-acetic acid Structure
Thiol-PEG3-acetic acid structure
Common Name Thiol-PEG3-acetic acid
CAS Number 200291-35-6 Molecular Weight 224.27500
Density N/A Boiling Point N/A
Molecular Formula C8H16O5S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Thiol-PEG3-acetic acid


Thiol-PEG3-acetic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 2-[2-[2-(2-sulfanylethoxy)ethoxy]ethoxy]acetic acid
Synonym More Synonyms

 Thiol-PEG3-acetic acid Biological Activity

Description Thiol-PEG3-acetic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

 Chemical & Physical Properties

Molecular Formula C8H16O5S
Molecular Weight 224.27500
Exact Mass 224.07200
PSA 103.79000
LogP 0.05060

 Synonyms

Acetic acid,[2-[2-(2-mercaptoethoxy)ethoxy]ethoxy]
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