2162-31-4
2162-31-4 structure
- Name: THP-PEG1-alcohol
- Chemical Name: Tetrahydropyranylethyleneglycol
- CAS Number: 2162-31-4
- Molecular Formula: C7H14O3
- Molecular Weight: 146.184
- Catalog: Pharmaceutical intermediate Heterocyclic compound Pyran compound
- Create Date: 2019-01-02 16:50:40
- Modify Date: 2025-08-21 19:24:28
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THP-PEG1-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
| Name | Tetrahydropyranylethyleneglycol |
|---|---|
| Synonyms |
2-(Tetrahydro-2H-pyran-2-yloxy)ethanol
Ethanol, 2-[(tetrahydro-2H-pyran-2-yl)oxy]- 2-(oxan-2-yloxy)ethanol |
| Description | THP-PEG1-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
|---|---|
| Related Catalog | |
| Target |
PEGs |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
| References |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 255.3±30.0 °C at 760 mmHg |
| Melting Point | 95ºC 22 mm Hg(lit.) |
| Molecular Formula | C7H14O3 |
| Molecular Weight | 146.184 |
| Flash Point | 108.2±24.6 °C |
| Exact Mass | 146.094299 |
| PSA | 38.69000 |
| LogP | -0.38 |
| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
| Index of Refraction | 1.460 |
| Safety Phrases | 23-24/25 |
|---|---|
| WGK Germany | 3 |
| HS Code | 2932999099 |
|
~90%
2162-31-4 |
| Literature: Eshghi, Hossein; Shafieyoon, Parvaneh Phosphorus, Sulfur and Silicon and the Related Elements, 2004 , vol. 179, # 10 p. 2149 - 2152 |
|
~85%
2162-31-4 |
| Literature: Gopinath, Pushparathinam; Nilaya, Surapaneni; Muraleedharan, Kannoth Manheri Organic Letters, 2011 , vol. 13, # 8 p. 1932 - 1935 |
|
~92%
2162-31-4 |
| Literature: Synthetic Communications, , vol. 36, # 18 p. 2705 - 2710 |
|
~95%
Detail
|
| Literature: Journal of Organic Chemistry, , vol. 63, # 23 p. 8183 - 8187 |
|
~%
2162-31-4 |
| Literature: Canadian Journal of Chemistry, , vol. 65, p. 213 - 223 |
|
~%
2162-31-4 |
| Literature: Canadian Journal of Chemistry, , vol. 65, p. 213 - 223 |
| Precursor 3 | |
|---|---|
| DownStream 5 | |
| HS Code | 2932999099 |
|---|---|
| Summary | 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |